Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 3 Issue 4

Epilepsy and Cortical Malformation Type Schizencephaly: Concerning Two Cases Revealed in Young Adult

Eric Gueumekane Bila Lamou1*, Adjaratou Dieynabou Sow1, Anna Modji Basse Faye1, Yacouba Njankouo Mapoure2, Soumaila Boubacar1, Ngor Side Diagne1, Kamadore Toure1, Moustapha Ndiaye1, Amadou Gallo Diop1 and Mouhamadou Mansour Ndiaye1

1Neurological Clinic, Fann Teaching Hospital, Dakar, Fann, Senegal
2Douala General Hospital, Cameroon

*Corresponding Author: Eric Gueumekane Bila Lamou, Neurological Clinic, Fann Teaching Hospital, Dakar, Fann, Senegal.

Received: February 28, 2020 March 17, 2020; Published: March 30, 2020

×

Abstract

Introduction: The Cortical malformations are one of important causes of epilepsy, mental retardation and other neurological disorders. The Schizencephaly is an abnormality of the cortical organization characterized by cracks connecting the pial’s surface to the lateral ventricle. Considered as a sporadic anomaly, its genetic origin is likely, involving an EMX2 gene mutation. The clinic depends on the size and location of the slot, and the age of diagnosis.

Patients and Methods: We report clinical observations of a 32-year old woman and a man of 41 years. The Clinical presentation was totally different but they had a single common denominator as seizures with variable onset and type, which were the origin of diagnosis. Their evolution had been variable with drug resistance in one case and a neurosurgical derivation for tetraventricular hydrocephalus.

Discussion and Conclusion: Schizencephaly is a source of earlier onset often focal seizures. Late onset in our case denotes of a certain brain adaptation. Imagery is paramount in the positive diagnosis and the lesional checking.

Keywords: Schizencephaly; Epilepsy; Drug Resistance; Dakar; Senegal

×

References

  1. Hayashi N., et al. “Morphological features and associated anomalies of schizencephaly in the clinical population: detailed analysis of MR images”. Neuroradiology5 (2002): 418-427.
  2. Senol U., et al. “Dizygotic Twins with schizencephaly and focal cortical”. American Journal of Neuroradiology 8 (2000): 1520-1521.
  3. Castroviiejo P., et al. “Schizencephaly: A study of 16 patients”. Neurologia 8 (2012): 491-499.
  4. N Cherif Idrissi El Ganouni., et al. “What do you know about schizencephaly? About 11 cases”. Radiology Department, Mohamed VI Teaching Hospital, Marrakech, Morocco. JFR (2011): 01292.
  5. Granata T., et al. “Schizencephaly: neuroradiologic and epileptogenic findings”. Epilepsia 12 (1996): 1185-1193.
  6. Ozkur A., et al. “Second trimester diagnosis of ostéogénesis imperfecta associated with schizencephaly by sonography”. Saudi Medical Journal 8 (2007): 1289-1378.
  7. The rum M. “Radio-anatomy of the anterior part of the arterial circle of the brain: anatomical variations and aneurysmal pathology”. Memory Certificate of Anatomy, Imaging and Morphogenesis, University of Nantes (2011).
  8. Muhamed J. “Contribution of MRI in the assessment of malformations of cortical development”. Optional specialty memory Radiology Sidi Mohammed Ben Abdellah University (2014).
  9. Guerrini R., et al. “Epilepsy and malformations of the cerebral cortex”. Neurologia3 (1999): 34-47.
  10. Florence G. “The physiology of cerebral circulation”. Bulletin de l'Académie Vétérinaire 3 (2004).
  11. Omezzin Jerbi S., et al. “Schizencephaly of type 1 or closed slit form: appearance in magnetic resonance imaging”. Archives de Pédiatrie 7 (2012): 762-764.
  12. Dies AK., et al. “Schizencephaly: Association with young maternal Age, Alcohol Use, and Lack of Prenatal care”. Journal of Child Neurology 2 (2013): 198-203.
  13. Avcu S., et al. “Bilateral giant open lip schizencephaly with associated cerebral anormalies: a case report”. Cases Journal 2 (2009): 7012-7014.
  14. Jiddi K., et al. “Imaging Atlas of Brain Malformations in Children: For Dummies”. Pediatric radio service CHU Mohamed VI. Mother hospital child Marrakech Morocco (2013).
  15. Cottier JP., et al. “Cortical malformations and epilepsy: contribution of MRI”. Journal of Radiology 87 (2006): 1621-1654.
  16. Coates EE., et al. “A case of schizencephaly associated with obsessive-compulsive disorder”. Annals of Clinical Psychiatry 2 (2013): 151-152.
  17. Christophe C., et al. “Ultrasound and MR imaging in periventricular leukomalacia”. Revue Medicale de Bruxelles 3 (2003): 154-161.
  18. Hornoy P., et al. “Prenatal detection of brain anomalies with ultrasonography”. Journal of Radiology 2 (2011): 111-117.
  19. Karen Y., et al. “Fetal schizencephaly: Pré and post natal. Imaging with review of the clinical Manifestations”. Radiographics3 (2007): 647-657.
  20. Sharma N., et al. “Bilateral schizencephaly Type II”. Australasian Medical Journal 3 (2014): 157-160.
  21. Megiddo L., et al. “Health and economic benefits of public financing of epilepsy treatment in India: An agent-based simulation model”. Epilepsia3 (2016): 464-474.
  22. M Avellanet., et al. “An unusual clinical presentation of bilateral schizencephaly”. Surgical and Radiologic Anatomy4 (1996): 271-273.
  23. V Humbertclaude., et al. “Schizencephaly and malformation of the upper limb”. Archives of Pediatrics 4 (1996): 357-358.
  24. JP Cottier., et al. “Cortical malformation and epilepsy: contribution of MRI”. Radiology Journal11 (2006): 1621-1634.
×

Citation

Citation: Eric Gueumekane Bila Lamou., et al “Epilepsy and Cortical Malformation Type Schizencephaly: Concerning Two Cases Revealed in Young Adult"Acta Scientific Neurology 3.4 (2020): 44-49.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US