Antimicrobial Activity of Red Sea Weed Ceramium diaphanum Against Pathogenic Bacteria
Swapnil Patil and DB Nakade*
Department of Microbiology, Rajaram College, Kolhapur, India
*Corresponding Author: DB Nakade, Professor, Department of Microbiology, Rajaram College, Kolhapur, India.
Received:
March 25, 2025; Published: April 08, 2025
Abstract
In the present study, antimicrobial activity of the extracts against pathogenic bacteria and fungi was performed by agar diffusion method. It exhibited potent activity against all tested microorganisms. The ethanol and chloroform extracts demonstrated significant antibacterial activity against various pathogenic bacteria, including E. coli, P. aeruginosa, S. aureus, V. cholerae, and methicillin-resistant S. aureus (MRSA). These results may be helpful for use of this seaweed in the health care.
Keywords: Antimicrobial; Ceramium diaphanum; MRSA
References
- Lee ZJ., et al. “Optimization of Ultrasonic Extraction Parameters for the Recovery of Phenolic Compounds in Brown Seaweed: Comparison with Conventional Technique”. Antioxidants 4 (2024): 409.
- Abdul Aziz S D. “Phytol-containing seaweed extracts as control for Ganoderma boninense”. Journal of Oil Palm Research (2019).
- Shobier A H., et al. “Variation in Anti-inflammatory, Anti-arthritic, and Antimicrobial Activities of Different Extracts of Common Egyptian Seaweeds with an Emphasis on Their Phytochemical and Heavy Metal Contents”. Biological Trace Element Research 4 (2023): 2071-2087.
- Coelho M and Pacheco R. “Anti-Hypercholesterolemia Effects of Edible Seaweed Extracts and Metabolomic Changes in Hep-G2 and Caco-2 Cell Lines”. Life 6 (2023): 1325.
- Huang CY., et al. “Compressional-Puffing Pretreatment Enhances Neuroprotective Effects of Fucoidans from the Brown Seaweed Sargassum hemiphyllum on 6-Hydroxydopamine-Induced Apoptosis in SH-SY5Y Cells”. Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry 1 (2017): 78.
- Song L., et al. “A Comparative Analysis of the Anti-Tumor Activity of Sixteen Polysaccharide Fractions from Three Large Brown Seaweed, Sargassum horneri, Scytosiphon lomentaria, and Undaria pinnatifida”. Marine Drugs 7 (2024): 316.
- Padam B S., et al. “Optimization of an Innovative Hydrothermal Processing on Prebiotic Properties of Eucheuma denticulatum, a Tropical Red Seaweed”. Applied Sciences 3 (2023): 1517.
- Chakraborty K., et al. “Antioxidant activities and phenolic contents of three red seaweeds (Division: Rhodophyta) harvested from the Gulf of Mannar of Peninsular India”. Journal of Food Science and Technology4 (2015): 1924-1935.
- Carpena M., et al. “Biological properties and potential of compounds extracted from red seaweeds”. Phytochemistry Review (2022): 1-32.
- El Gamal AA. “Biological importance of marine algae”. Saudi Pharmaceutical Journal1 (2010): 1-25.
- Protopapa M., et al. “Evaluation of antifouling potential and ecotoxicity of secondary metabolites derived from red algae of the genus Laurencia”. Marine Drugs11 (2010): 646.
- Jesus A., et al. “Isolation and potential biological applications of haloaryl secondary metabolites from macroalgae”. Marine Drugs2 (2019): 73.
- Pérez M J., et al. “Antimicrobial action of compounds from marine seaweed”. Marine Drugs3 (2021): 52.
- Alarif W M., et al. “Rare acetogenins with anti-inflammatory effect from the red alga Laurencia obtuse”. Molecules3 (2019): 476.
- Liao WR., et al. “Antibiotic activity of lectins from marine algae against marine vibrios”. Journal of Industrial Microbiology and Biotechnology 7 (2003): 433-439.
- S Yadav., et al. “FT-IR Spectroscopic Analysis of Holoptelea integrifolia (Roxb.) Planch Seed Extracts and their Antibacterial Activity”. Research Journal of Medicinal Plant 8 (2015): 417-426.
- Cuellar-Bermudez S P., et al. “Extraction and purification of high-value metabolites from microalgae: Essential lipids, astaxanthin and phycobiliproteins”. Microbial Biotechnology2 (2015): 190-209.
- Wasihun Y., et al. “Antibacterial activity and phytochemical components of leaf extract of Calpurnia aurea”. Scientific Reports1 (2023): 9767.
- Karabay-Yavasoglu N U., et al. “Antimicrobial activity of volatile components and various extracts of the red alga Jania rubens”. Phytotherapy Research2 (2007): 153-156.
- Alghazeer R., et al. “Alkaloids Rich Extracts from Brown Algae Against Multidrug-Resistant Bacteria by Distinctive Mode of Action”. Arabian Journal for Science and Engineering1 (2022): 179-188.
- Yap WF., et al. “Decoding Antioxidant and Antibacterial Potentials of Malaysian Green Seaweeds: Caulerpa racemosa and Caulerpa lentillifera”. Antibiotics (Basel)3 (2019): 152.
- Johari M A and Khong H Y. “Total phenolic content and antioxidant and antibacterial activities of Pereskia bleo”. Advances in Pharmacological Sciences (2019): 7428593.
- Karimzadeh K and Zahmatkesh A. “Phytochemical screening, antioxidant potential, and cytotoxic effects of different extracts of red algae (Laurencia snyderiae) on HT29 cells”. Research in Pharmaceutical Sciences 4 (2021): 400-413.
- Gonfa T., et al. “Phytochemicals analysis, in vitro antibacterial activities of extracts, and molecular docking studies of the isolated compounds from Melhania zavattarii Cufod leaves”. Journal of Tropical Medicine (2023): 8820543.
- El-Bilawy E H., et al. “Antifungal, antiviral, and HPLC analysis of phenolic and flavonoid compounds of Amphiroa anceps extract”. Sustainability19 (2022): 12253.
- Pereira L and Valado A. “Red algae compounds: Potential neuroprotective agents for neurodegenerative disorders”. OBM Neurobiology2 (2024): 1-27.
- Khaleel T H and Dwaish A S. “Antifugall Activity and Qualitative Phytochemical Investigation of Spirogyra Aequinoctialis Hexanic Extract in Iraq”. IOP Conf. Ser. Earth Environ. Sci.,5 (2023): 052028.
- Pourakbar L., et al. “Antifungal activity of the extract of a macroalgae, Gracilariopsis persica, against four plant pathogenic fungi”. Plants9 (2021): 1781.
- Azzam I., et al. “Antifungal activities of the marine green and red macro algae extracts against some phytopathogenic fungi”. International Journal of Environmental Studies and Research4 (2023): 1-14.
- Mekam PN., et al. “Phenolic compounds profile of water and ethanol extracts of Euphorbia hirta L. leaves showing antioxidant and antifungal properties”. South African Journal of Botany 127 (2019): 319-332.
- Sá F A da S., et al. “Antifungal activity of the ethanolic extract and flavonoid avicularin from Myrcia tomentosa (Aubl.) DC. on virulence factors of Candida species”. Journal of Herbal Medicine 38 (2023): 100643.
- Cushnie T P T and Lamb AJ. “Antimicrobial activity of flavonoids”. International Journal of Antimicrobial Agents5 (2005): 343-356.
- Rodríguez B., et al. “Mechanisms of action of flavonoids: Antioxidant, antibacterial and antifungal properties”. Cac2 (2023): 33-66.
- Susilawati S., et al. “Flavonoid as Anti-Candida Agents”. Indonesian Journal of Fundamental and Applied Chemistry 2 (2023): 88-97.
- Veiko A G., et al. “Antimicrobial activity of quercetin, naringenin and catechin: Flavonoids inhibit Staphylococcus aureus-induced hemolysis and modify membranes of bacteria and erythrocytes”. Molecules3 (2023): 1252.
- Dzoyem J P., et al. “Antimicrobial action mechanism of flavonoids from Dorstenia species”. Drug Discovery Therapy 7.2 (2013): 66-72.
- Miklasińska-Majdanik M., et al. “Phenolic compounds diminish antibiotic resistance of Staphylococcus aureus clinical strains”. International Journal of Environmental Research and Public Health 10 (2018): 2321.
- Hellewell L and Bhakta S. “Chalcones, stilbenes and ketones have anti-infective properties via inhibition of bacterial drug-efflux and consequential synergism with antimicrobial agents”. Access Microbiology 4 (2020).
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