Acta Scientific Microbiology

Research Article Volume 8 Issue 4

Adequate Method of Hepatitis C Virus (HCV) RNA Quantitation and Geographical Distribution of Subjects in Eastern Uttar Pradesh: Findings from a Tertiary Care Hospital

Vivek Gaur*

Department of Microbiology, Baba Raghav Das Medical College Gorakhpur, Uttar Pradesh, India

*Corresponding Author: Vivek Gaur, Department of Microbiology, Baba Raghav Das Medical College Gorakhpur, Uttar Pradesh, India.

Received: February 17, 2025; Published: March 20, 2024

Abstract

Background: Hepatitis C virus (HCV) have several important features, including worldwide distribution, hepatotropism, modes of transmission, ability to life threatening critical illness and is a growing public health issue worldwide. It’s prevalence and mode of transmission varies greatly in different parts of the world. It is estimated that approximately one-fifth of the world population infected with HCV.

Aim of the Study: This study was planned to know the prevalence, demographic and geographical distribution of HCV in eastern Uttar Pradesh, India.

Material and Methods: An observational study was conducted in the department of Microbiology for 2 years from January 2023 to December 2024. Irrespective of age and sex, a non-duplicate blood samples were taken to detect HCV infection. All samples were tested for rapid HCV antibody test followed by viral load testing by using RT-PCR technique.

Results were interpreted according to standard protocol.

Results: Out of 1831 patient’s samples, 1266 (69.14%) patients were from outpatient department (OPD) and 565 (30.86%) were from inpatient department (IPD). 1053 (57.50%) were male patients and 778 (42.49%) were female patients. In study, most of the patients visited in MTC unit from Gorakhpur division (69.85%) of Uttar Pradesh followed by Basti (13%) division. Among positive cases, only 5.83% of cases has viral load less than 300 IU/ml.

Conclusion: Hepatitis virus infection was highest in the age group 19-40 and lowest in the age group above <18 years. Hepatitis C was more in males as compared to females and more in OPD as compared to IPD.

Keywords: Hepatitis C Virus; Hepatocellular Carcinoma; Eastern Mediterranean Region; National Viral Hepatitis Control Program; HCV Prevalence; HCV in Eastern Uttar Pradesh

References

  1. Axley P., et al. “Hepatitis C Virus and Hepatocellular Carcinoma: A Narrative Review”. Journal of Clinical and Translational Hepatology6.1 (2018): 79-84.
  2. Mehta P., et al. “Viral Hepatitis”. Treasure Island (FL): Stat Pearls Publishing; (2024). 
  3. Zaltron S., et al. “Chronic HCV infection: epidemiological and clinical relevance”. BMC Infectious Disease12 (2012).
  4. Hepatitis C fact sheet (2024).
  5. Jothi BJ., et al. “Insights into the Epidemiology of Hepatitis C Virus Infection in Delhi: Findings from a Tertiary Care Hospital”. International Journal of Medicine and Public Health 3 (2023): 133-136.
  6. Olaru ID., et al. “Global prevalence of hepatitis B or hepatitis C infection among patients with tuberculosis disease: systematic review and meta-analysis”. E Clinical Medicine58 (2023): 101938.
  7. Puri P., et al. “Consensus Statement of HCV Task Force of the Indian National Association for Study of the Liver (INASL). Part II: INASL Recommendations for Management of HCV in India”. Journal of Clinical and Experimental Hepatology 2 (2012): 117-140.
  8. Dhiman RK., et al. “Tackling the Hepatitis C Disease Burden in Punjab, India”. Journal of Clinical and Experimental Hepatology 3 (2016): 224-232.
  9. Huang P., et al. “The risk of hepatitis C virus recurrence in hepatitis C virus-infected patients treated with direct-acting antivirals after achieving a sustained virological response: A comprehensive analysis”. Liver International10 (2021): 2341-2357.
  10. Web Annex C. Estimates of the coverage of diagnosis and treatment for hepatitis B and C virus infection, by WHO region and income group, 2015. Centre for Disease Analysis. In: Global hepatitis report 2017 (2017).
  11. Jeong D., et al. “Treatment of HCV with direct-acting antivirals on reducing mortality related to extrahepatic manifestations: a large population-based study in British Columbia, Canada”. The Lancet Regional Health – Americas 29 (2023):
  12. Q-line Biotech. Rapid test. HCV Antibody (3rd Generation).
  13. Molbio Diagnostics Limited. Truenat HCV. Chip-based Real Time PCR Test for Hepatitis C Virus.
  14. Sivaranjini K., et al. “Spectrum of hepatitis B and hepatitis C-related cancers in India”.E cancer 18 (2024):
  15. Shaikh KD., et al. “Hepatitis in India: challenges, efforts, and recommendations”. International Journal of Surgery: Global Health2 (2021): e118.
  16. Oberoi ML., et al. “Prevalence of Acute Viral Hepatitis in Symptomatic Patients in a Tertiary Care Hospital of North India”. Journal of Advances in Microbiology 11 (2022): 67-71.
  17. Parveen M., et al. “Prevalence of Hepatitis B and Hepatitis C in Tertiary Care Center of Northern India”. Advanced Research in Gastroenterology and Hepatology 4 (2020): 555918.
  18. Irshad M., et al. “Viral hepatitis in India: Current status”. Gastroenterology Hepatology and Endoscopy 1 (2018).
  19. Wait S., et al. “Hepatitis B and hepatitis C in southeast and southern Asia: challenges for governments”. Lancet Gastroenterology and Hepatology3 (2016): 248-255.
  20. Bhaumik P. “Epidemiology of Viral Hepatitis and Liver Diseases in India”. Euroasian Journal of Hepato-gastroenterology 1 (2015): 34-36.
  21. Bhate P., et al. “Cross sectional study of prevalence and risk factors of hepatitis b and hepatitis c infection in a rural village of India”. Arquivos de Gastroenterologia 4 (2015): 321-324.

Citation

Citation: Vivek Gaur. “Adequate Method of Hepatitis C Virus (HCV) RNA Quantitation and Geographical Distribution of Subjects in Eastern Uttar Pradesh: Findings from a Tertiary Care Hospital".Acta Scientific Microbiology 8.4 (2025): 27-31.

Copyright

Copyright: © 2025 Vivek Gaur. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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