Acta Scientific Microbiology

Research Article Volume 8 Issue 3

A Systematic Review (Before 31 August 2024) on the Applications of Yarrowia lipolytica

Victor R Lukianto1,2, Keng Yao Yeo1,2, Madhunisha Arivazhagan1,2, Ashmitha Senthilkumar1,2, Tanisha Saisudhanbabu1,2, Minh Anh Le1,2, Travina BS Wong1,2 and Maurice HT Ling1,2,3*

1School of Life Sciences, Management Development Institute of Singapore, Singapore1 2Department of Applied Sciences, Northumbria University, United Kingdom1 3HOHY PTE LTD, Singapore

*Corresponding Author: Maurice HT Ling, School of Life Sciences, Management Development Institute of Singapore, Singapore.

Received: February 06, 2025; Published: February 22, 2025

Abstract

Yarrowia lipolytica in both traditional and industrial processes due to its break down materials that are commonly found in the waste, and as a bio-factory for the production of target products such as biofuels. To date, no systematic review on the applications of Y. lipolytica has been published. Hence, we present a systematic review on the applications of Y. lipolytica using studies indexed in PubMed up to 31 August 2024. 40 out of original 59 articles were included. Three main themes were identified; namely, (i) Improving efficiency in industrial processes, (ii) Strain survey and (iii) Target products.

Keywords:Valorization; Biofactory; Waste Management; Lipids; Proteins; Fatty acids

References

  1. Lanciotti R., et al. “Use of Yarrowia lipolytica strains for the treatment of olive mill wastewater”. Bioresource Technology3 (2005): 317-322.
  2. Sinigaglia M., et al. “Biochemical and physiological characteristics of Yarrowia lipolytica strains in relation to isolation source. Canadian Journal of Microbiology1 (1994): 54-59.
  3. Worland AM., et al. “Analysis of Yarrowia lipolytica growth, catabolism, and terpenoid biosynthesis during utilization of lipid-derived feedstock”. Metabolic Engineering Communications 11 (2020): e00130.
  4. Gardini F., et al. “A survey of yeasts in traditional sausages of southern Italy”. FEMS Yeast Research2 (2001): 161-167.
  5. Vong WC., et al. “Biotransformation with cellulase, hemicellulase and Yarrowia lipolytica boosts health benefits of okara”. Applied Microbiology and Biotechnology19 (2017): 7129-7140.
  6. Hamimed S., et al. “Dual Valorization of Olive Mill Wastewater by Bio-Nanosynthesis of Magnesium Oxide and Yarrowia lipolytica Biomass Production”. Chemistry and Biodiversity3 (2020): e1900608.
  7. Coleman SM., et al. “Evolving tolerance of Yarrowia lipolytica to hydrothermal liquefaction aqueous phase waste”. Applied Microbiology and Biotechnology5-6 (2023): 2011-2025.
  8. Hamimed S., et al. “High-performance biological treatment of tuna wash processing wastewater using Yarrowia lipolytica”. Environmental Science and Pollution Research International2 (2021): 1545-1554.
  9. Žganjar M., et al. “High-throughput screening of non-conventional yeasts for conversion of organic waste to microbial oils via carboxylate platform”. Scientific Reports1 (2024): 14233.
  10. Kothri M., et al. “Microbial sources of polyunsaturated fatty acids (PUFAs) and the prospect of organic residues and wastes as growth media for PUFA-producing microorganisms”. FEMS Microbiology Letters5 (2020): fnaa028.
  11. Gamraoui A., et al. “Musico-bioremediation of seafood canning wastewater by Yarrowia lipolytica”. World Journal of Microbiology and Biotechnology11 (2023): 303.
  12. Katre G., et al. “Mutants of Yarrowia lipolytica NCIM 3589 grown on waste cooking oil as a biofactory for biodiesel production. Microbial Cell Factories1 (2017): 176.
  13. Do DTH., et al. “Organic Wastes as Feedstocks for Non-Conventional Yeast-Based Bioprocesses”. Microorganisms8 (2019): 229.
  14. Fraga JL., et al. “Palm oil wastes as feedstock for lipase production by Yarrowia lipolytica and biocatalyst application/reuse”. 3 Biotech4 (2021): 191.
  15. Peterson EC., et al. “Single cell protein and oil production from solid cocoa fatty acid distillates co-fed ethanol”. Bioresource Technology 387 (2023): 129630.
  16. Wang S., et al. “Sustainable biosynthesis of squalene from waste cooking oil by the yeast Yarrowia lipolytica”. Metabolic Engineering Communications 18 (2024): e00240.
  17. Han Z., et al. “Valorization of papaya fruit waste through low-cost fractionation and microbial conversion of both juice and seed lipids”. RSC Advances49 (2018): 27963-27972.
  18. Magdouli S., et al. “Valorization of raw glycerol and crustacean waste into value added products by Yarrowia lipolytica”. Bioresource Technology 243 (2017): 57-68.
  19. Cordova LT., et al. “Valorizing a hydrothermal liquefaction aqueous phase through co-production of chemicals and lipids using the oleaginous yeast Yarrowia lipolytica”. Bioresource Technology 313 (2020): 123639.
  20. Lopes M., et al. “Yarrowia lipolytica as a biorefinery platform for effluents and solid wastes valorization - challenges and opportunities”. Critical Reviews in Biotechnology2 (2022): 163-183.
  21. Munn Z., et al. “Systematic Review or Scoping Review? Guidance for Authors When Choosing Between a Systematic or Scoping Review Approach”. BMC Medical Research Methodology1 (2018): 143.
  22. Grant MJ and Booth A. “A Typology of Reviews: An Analysis of 14 Review Types and Associated Methodologies”. Health Information and Libraries Journal2 (2009): 91-108.
  23. Ling MH., et al. “Yarrowia lipolytica as a Valorization Biofactory”. SynBioSG Conference 2024 (Matrix, Biopolis, Singapore) (2024).
  24. Liberati A., et al. “The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies that Evaluate Health Care Interventions: Explanation and Elaboration”. PLoS Medicine7 (2009): e1000100.
  25. Moher D., et al. “Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement”. PLoS Medicine 6 (7 (2009): e1000097.
  26. Wang Z., et al. “Adaptive laboratory evolution of Yarrowia lipolytica improves ferulic acid tolerance”. Applied Microbiology and Biotechnology4 (2021): 1745-1758.
  27. Yu J., et al. “Bioengineering triacetic acid lactone production in Yarrowia lipolytica for pogostone synthesis”. Biotechnology and Bioengineering9 (2018): 2383-2388.
  28. Zhou L., et al. “Combined adaptive evolution and transcriptomic profiles reveal aromatic aldehydes tolerance mechanisms in Yarrowia lipolytica”. Bioresource Technology 329 (2021): 124910.
  29. Narisetty V., et al. “Development of Hypertolerant Strain of Yarrowia lipolytica Accumulating Succinic Acid Using High Levels of Acetate”. ACS Sustainable Chemistry and Engineering33 (2022): 10858-10869.
  30. Delfau-Bonnet G., et al. “Evaluation of the Potential of Lipid-Extracted Chlorella vulgaris Residue for Yarrowia lipolytica Growth at Different pH Levels”. Marine Drugs4 (2022): 264.
  31. Georgiadis I., et al. “Identification and Construction of Strong Promoters in Yarrowia lipolytica Suitable for Glycerol-Based Bioprocesses”. Microorganisms5 (2023): 1152.
  32. Shi X., et al. “Isopropanol biosynthesis from crude glycerol using fatty acid precursors via engineered oleaginous yeast Yarrowia lipolytica”. Microbial Cell Factories1 (2022): 168.
  33. Lucia V., et al. “Use of Fourier transform infrared spectroscopy to evaluate the proteolytic activity of Yarrowia lipolytica and its contribution to cheese ripening. International Journal of Food Microbiology1-2 (2001): 113-123.
  34. Tsirigka A., et al. “Novel evolved Yarrowia lipolytica strains for enhanced growth and lipid content under high concentrations of crude glycerol”. Microbial Cell Factories1 (2023): 62.
  35. Dulermo R., et al. “Using a vector pool containing variable-strength promoters to optimize protein production in Yarrowia lipolytica”. Microbial Cell Factories1 (2017): 31.
  36. Rakicka M., et al. “An Effective Method of Continuous Production of Erythritol from Glycerol by Yarrowia lipolytica MK1”. Food Technology and Biotechnology1 (2017): 125-130.
  37. Lubuta P., et al. “Investigating the Influence of Glycerol on the Utilization of Glucose in Yarrowia lipolytica Using RNA-Seq-Based Transcriptomics”. G3 (Bethesda, Md)12 (2019): 4059-4071.
  38. Guerzoni ME., et al. “Variability of the lipolytic activity in Yarrowia lipolytica and its dependence on environmental conditions”. International Journal of Food Microbiology1-2 (2001): 79-89.
  39. Lanciotti R., et al. “Effects of growth conditions on the resistance of some pathogenic and spoilage species to high pressure homogenization”. Letters in Applied Microbiology2 (1996): 165-168.
  40. Fontanille P., et al. “Bioconversion of volatile fatty acids into lipids by the oleaginous yeast Yarrowia lipolytica”. Bioresource Technology 114 (2012): 443-449.
  41. Juszczyk P., et al. “Biomass production by novel strains of Yarrowia lipolytica using raw glycerol, derived from biodiesel production”. Bioresource Technology 137 (2013): 124-131.
  42. Papanikolaou S., et al. “Conversion of biodiesel-derived glycerol into biotechnological products of industrial significance by yeast and fungal strains”. Engineering in Life Sciences3 (2017): 262-281.
  43. Filippousi R., et al. “Isolation, identification and screening of yeasts towards their ability to assimilate biodiesel-derived crude glycerol: microbial production of polyols, endopolysaccharides and lipid”. Journal of Applied Microbiology4 (2019): 1080-1100.
  44. Louhasakul Y., et al. “Metagenomic insights into bioaugmentation and biovalorization of oily industrial wastes by lipolytic oleaginous yeast Yarrowia lipolytica during successive batch fermentation”. Biotechnology and Applied Biochemistry6 (2020): 1020-1029.
  45. Sarris D., et al. “Production of Added-Value Chemical Compounds through Bioconversions of Olive-Mill Wastewaters Blended with Crude Glycerol by a Yarrowia lipolytica Strain”. Molecules (Basel, Switzerland)2 (2019): 222.
  46. Azevedo DMF., et al. “Recovery of lanthanides from hydrocarbon cracking spent catalyst through chemical and biotechnological strategies”. Journal of Environmental Science and Health Part A, Toxic/Hazardous Substances and Environmental Engineering7 (2019): 686-693.
  47. Papanikolaou S., et al. “Yarrowia lipolytica as a potential producer of citric acid from raw glycerol”. Journal of Applied Microbiology4 (2002): 737-744.
  48. Guerzoni ME., et al. “Survey of the physiological properties of the most frequent yeasts associated with commercial chilled foods”. International Journal of Food Microbiology4 (1993): 329-341.
  49. Vannini L., et al. “Evaluation of Fourier-transform infrared spectroscopy for data capture in predictive microbiology”. World Journal of Microbiology and Biotechnology1 (1996): 85-90.
  50. Sarris D., et al. “Growth Response of Non-Conventional Yeasts on Sugar-Rich Media: Part 2: Citric Acid Production and Circular-Oriented Valorization of Glucose-Enriched Olive Mill Wastewaters Using Novel Yarrowia lipolytica Strains”. Microorganisms9 (2023): 2243.
  51. Tomaszewska L., et al. “Production of erythritol and mannitol by Yarrowia lipolytica yeast in media containing glycerol”. Journal of Industrial Microbiology and Biotechnology9 (2012): 1333-1343.
  52. Darvishi F., et al. “Production of Laccase by Recombinant Yarrowia lipolytica from Molasses: Bioprocess Development Using Statistical Modeling and Increase Productivity in Shake-Flask and Bioreactor Cultures”. Applied Biochemistry and Biotechnology3 (2017): 1228-1239.
  53. Kubiak M., et al. “Thermal treatment improves a process of crude glycerol valorization for the production of a heterologous enzyme by Yarrowia lipolytica”. Biotechnology Reports (Amsterdam, Netherlands) 31 (2021): e00648.

Citation

Citation: HT Ling., et al. “A Systematic Review (Before 31 August 2024) on the Applications of Yarrowia lipolytica".Acta Scientific Microbiology 8.3 (2025): 586557.

Copyright

Copyright: © 2025 HT Ling., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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