Gitali Bhagawati¹*, Yasir Rizvi², Lakshmi Kant Jha³, Bhavana Chauhan⁴, Domathoti Yashwanth⁵ and Rekha Saji Kumar⁶

¹MBBS, MD (Microbiology), PGDHM, CIC, Senior Consultant and Clinical Lead, Department of Microbiology, and Infection Control, Narayana Health, Dharamshila Narayana Superspeciality Hospital, Delhi, India
²MBBS, MD (Internal Medicine), DM (Nephrology), Senior Consultant and Director Nephrology, Narayana Health, Dharamshila Narayana Superspeciality Hospital, Delhi, India
³MBBS, MD - General Medicine, DM - Nephrology, Senior Consultant and Director, Nephrology, Narayana Health, Dharamshila Narayana Superspeciality Hospital, Delhi, India
⁴MBBS, MD (Microbiology), Senior Resident, Department of Microbiology, Narayana Health, Dharamshila Narayana Superspeciality Hospital, Delhi, India
⁵Infection Control Nurse, Narayana Health, Dharamshila Narayana Superspeciality Hospital, Delhi, India
⁶Technical Supervisor, Department of Microbiology, Narayana Health, Dharamshila Narayana Superspeciality Hospital, Delhi, India

*Corresponding Author: Gitali Bhagawati, MBBS, MD (Microbiology), PGDHM, CIC, Senior Consultant and Clinical Lead, Department of Microbiology, and Infection Control, Narayana Health, Dharamshila Narayana Superspeciality Hospital, Delhi, India.

Received: December 13, 2024; Published: January 28, 2025

Abstract

Introduction:Urinary tract infections (UTIs) is one of the most common healthcare-associated infections (HAI) in patients with chronic renal failure (CKD).

Objective: The objective of the study was to evaluate the incidence of UTI and possible risk factors among patients with CKD. Uropathogens and their antimicrobial susceptibility pattern (AST) were also evaluated in this group of patients.

Methods: This retrospective study was carried out over a period of 22 months in a tertiary care hospital in Delhi. A total of 310 urine samples were received in the department of microbiology from patients of nephrology unit with CKD. Urine samples were processed on Cysteine Lactose Electrolyte Deficient (CLED) agar and incubated aerobically at 37°C for 24-48 hrs. Complete work-up was done in case of significant growth (SG) with colony count ≥104 CFU/ml.

Results: Indwelling catheter, previous history of UTI and pyuria (>=10/ high power field) were found to have strong association with SG (p value <0.05). On the contrary, hyperglycaemia, dialysis, and grade of CKD were not found to have statistically significant correlation with SG (p value >0.05). The most common urinary isolate was E. coli, 36 (28.57%) followed by Enterococcus spp. 22 (17.46%). Among enterobacterales, meropenem resistance was 49.12% (31/57) while colistin resistance was found to be 5.71% (2/35).

Conclusion: CKD is associated with a proinflammatory milieu with impaired innate and acquired immunity leading to infections. Minimal invasive procedures along with judicious use of antibiotics based on local antibiogram can provide better outcome among these patients.

Keywords: Chronic Kidney Disease (CKD); Estimated Glomerular Filtration Rate (eGFR); Urinary Tract Infections (UTIs); Antimicrobial Susceptibility (AST); Estimated Glomerular Filtration Rate (eGFR); Escherichia coli

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Citation

Citation: Gitali Bhagawati., et al. “Microbiological Evaluation of Urinary samples in A Cohort of Patients with Chronic Renal Failure".Acta Scientific Microbiology 8.2 (2025): 90-98.

Copyright

Copyright: © 2025 Gitali Bhagawati., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.