Acta Scientific Microbiology

Research Article Volume 7 Issue 8

Ror β proteins - Novel Target Discovered for Potentially Treating and Preventing Osteoarthritis of Tmj - A Systematic Review

Namitha MV1*, Merina Antony1, Gaurav2 and Karthik A3

1House Surgeon, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
2Associate Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
3Assistant Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India

*Corresponding Author: Namitha MV, House Surgeon, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.

Received: July 15, 2024; Published: July 29, 2024

Abstract

ROR β (Retinoic acid-related Orphan Receptor beta) proteins are members of the nuclear receptor superfamily of transcription factors. They play important roles in various biological processes such as cell differentiation, immune function, metabolism, and circadian rhythm regulation. Recently several preclinical studies have demonstrated the potential of ROR beta agonists as a therapeutic approach for osteoarthritis. A recent study showed that a ROR beta agonist reduced the expression of inflammatory cytokines and enzymes in chondrocytes from osteoarthritic cartilage and also the inhibition of ROR beta signaling reduced cartilage destruction in a mouse model of osteoarthritis. Furthermore, it also demonstrated the potential of a ROR beta agonist in promoting cartilage repair and reducing joint inflammation in osteoarthritis. This systematic review aims to highlight the significance of ROR β proteins as a promising therapeutic approach for Osteoarthritis of Temporomandibular Joint (TMJ).

Keywords: Osteoarthritis; ROR Beta Protein; Targeted Therapy; ROR Beta Agonist; Joint Inflammation

References

  1. JP Pelletier., et al. “Etiopathogenesis of osteoarthritis”. W.J. Koopman (Ed.), Arthritis and Allied Conditions. A textbook of Rheumatology (13 edn.), Williams & Wilkins, Baltimore (1997): 1969-1984.
  2. Anton M Jetten., et al. “The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes”. Progress in Nucleic Acid Research and Molecular Biology 69 (2001): 205-247.
  3. Matthew M Roforth., et al. “Identification of Rorβ targets in cultured osteoblasts and in human bone”. Biochemical and Biophysical Research Communications4 (2013): 768-773.
  4. Mi Ra Chang., et al. “RORβ modulates a gene program that is protective against articular cartilage damage”. Plos One10 (2022).
  5. Stella Rigoglou., et al. “The NF-B signalling pathway in osteoarthritis”. The International Journal of Biochemistry and Cell Biology 45 (2013) 2580-2584.
  6. LX Chen., et al. “Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA”. Osteoarthritis and Cartilage 16 (2008)174-184.
  7. Ruben Aquino-Martinez., et al. “miR-219a-5p Regulates Rorβ During Osteoblast Differentiation and in Age-related Bone Loss”. Journal of Bone and Mineral Research 1 (2019): 135-144.
  8. Qing Yao., et al. “Osteoarthritis: pathogenic signaling pathways and therapeutic targets”. Signal Transduction and Targeted Therapy56 (2023).

Citation

Citation: Namitha MV., et al. “Ror β proteins - Novel Target Discovered for Potentially Treating and Preventing Osteoarthritis of Tmj - A Systematic Review".Acta Scientific Microbiology 7.8 (2024): 183-187.

Copyright

Copyright: © 2024 Namitha MV., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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