Namitha MV¹*, Merina Antony¹, Gaurav² and Karthik A³

¹House Surgeon, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
²Associate Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India
³Assistant Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India

*Corresponding Author: Namitha MV, House Surgeon, Coorg Institute of Dental Sciences, Virajpet, Karnataka, India.

Received: July 15, 2024; Published: July 29, 2024

Abstract

ROR β (Retinoic acid-related Orphan Receptor beta) proteins are members of the nuclear receptor superfamily of transcription factors. They play important roles in various biological processes such as cell differentiation, immune function, metabolism, and circadian rhythm regulation. Recently several preclinical studies have demonstrated the potential of ROR beta agonists as a therapeutic approach for osteoarthritis. A recent study showed that a ROR beta agonist reduced the expression of inflammatory cytokines and enzymes in chondrocytes from osteoarthritic cartilage and also the inhibition of ROR beta signaling reduced cartilage destruction in a mouse model of osteoarthritis. Furthermore, it also demonstrated the potential of a ROR beta agonist in promoting cartilage repair and reducing joint inflammation in osteoarthritis. This systematic review aims to highlight the significance of ROR β proteins as a promising therapeutic approach for Osteoarthritis of Temporomandibular Joint (TMJ).

Keywords: Osteoarthritis; ROR Beta Protein; Targeted Therapy; ROR Beta Agonist; Joint Inflammation

References

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Citation

Citation: Namitha MV., et al. “Ror β proteins - Novel Target Discovered for Potentially Treating and Preventing Osteoarthritis of Tmj - A Systematic Review".Acta Scientific Microbiology 7.8 (2024): 183-187.

Copyright

Copyright: © 2024 Namitha MV., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.