Acta Scientific Microbiology

Editorial Volume 7 Issue 8

GS-5245, A New Oral Nucleoside Prodrug is Efficacious Against SARS-CoV-2 and Other Coronaviruses and Post-COVID-19 Conditions After COVID-19 Vaccination

Attapon Cheepsattayakorn1-4*, Ruangrong Cheepsattayakorn5 and Porntep Siriwanarangsun2

1Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
2Faculty of Medicine, Western University, Pathumtani Province, Thailand
310th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand
4Department of Disease Control, Ministry of Public Health, Thailand
5Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand

Received: June 17, 2024; Published: July 01, 2024

Abstract

recent retrospective study in the United States by using electronic health records (EHR) among positive-SARS-CoV-2 patients during March 2021 to February 2022. Both unvaccinated (161,531) and vaccinated (161,531) COVID-19 patients were matched on age, sex, acute infection severity, test date, and location. The analyzed data revealed that, except mental health disorders, vaccinated patients had lower risk of all post-COVID-19 conditions (PCC) categories (relative risk (RR): 1.06, 95% confidential interval (CI): 1.02-1.10) [1]. COVID-19 vaccination was related to lower risk of cardiovascular (RR: 0.88, 95% : 0.83-0.94), blood and hematologic (RR: 0.79, 95% CI: 0.71-0.89), more than 10% of lower risk of sensory (RR: 0.90, 95% CI: 0.86-0.95), skin and subcutaneous (RR: 0.69, 95% CI: 0.66-.72)

References

  1. Malden DE., et al. “Post-COVID conditions following COVID-19 vaccination : a retrospective matched cohort study of patients with SARS-CoV-2 infection”. Nature Communications 15 (2024): 4101.
  2. Martinez DR., et al. “The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses”. Science Translational Medicine748 (2024).

Citation

Citation: Attapon Cheepsattayakorn., et al. “GS-5245, A New Oral Nucleoside Prodrug is Efficacious Against SARS-CoV-2 and Other Coronaviruses and Post-COVID-19 Conditions After COVID-19 Vaccination".Acta Scientific Microbiology 7.8 (2024): 01-03.

Copyright

Copyright: © 2024 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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