Lamlom Taie Lamlom Tahawy*, Ari Susilowati and Sutarno Sutarno

Bioscience Study Program, Graduate Program, Universitas Sebelas Maret, Surakarta, Indonesia

*Corresponding Author: Lamlom Taie Lamlom Tahawy, Bioscience Study Program, Graduate Program, Universitas Sebelas Maret, Surakarta, Indonesia.

Received: June 03, 2024; Published: June 25, 2024

Abstract

Centella asiatica, commonly known as gotu kola, is a medicinal plant with a long history of use in traditional medicine. This literature review provides a comprehensive overview of recent research on Centella asiatica in Surakarta City, Indonesia. It focuses on four key areas: discovery, genetic diversity, antimicrobal potential, and cultivation. The review begins by outlining the importance of accurately identifying Centella asiatica species using DNA barcoding techniques. It then explores the genetic diversity of recently discovered or uncommon species of Centella asiatica within the Surakarta City District, emphasizing the importance of genetic variation for adaptability, resilience, and the advancement of improved varieties.

Moving on to the antimicrobal potential of Centella asiatica, the review examines the efficacy of Centella asiatica extracts against MRSA strains, emphasizing its therapeutic potential for medical applications. Finally, the review explores techniques for large-scale cultivation of Centella asiatica, with a particular focus on the Temporary Immersion System (TIS) as a promising approach for increased biomass production, optimal growth, and spatial efficiency. This literature review synthesizes the current knowledge on Centella asiatica in Surakarta City, Indonesia, and identifies promising avenues for future research and practical applications.

Keywords: Surakarta Centella Diversity; Antimicrobal Potential; Cultivation; DNA Barcoding

References

1. Y Sun., et al. "Gotu kola (Centella asiatica): Nutritional Properties and Plausible Health Benefits". in Frontiers in Pharmacology 11 (2020): 672.
2. M Razali., et al. "Centella asiatica (L.) Urb.: A Review on Its Botany, Ethnobotany, Phytochemistry, Pharmacology, and Toxicology". in Pharmaceutical Biology 57.1 (2019): 193-202.
3. Khwanchum S., et al. "DNA Barcoding of Thai Medicinal Plants: Authentication and Marker Development”. Plants 4 (2023).
4. Padmalatha C and Prasad M. "Genetic Diversity Assessment in Centella asiatica Populations Using RAPD Markers”. Indian Journal of Natural Products and Resources4 (2021).
5. Idris A and Nadzir M. "Antimicrobial Activity of Centella asiatica Extracts Against Methicillin-Resistant Staphylococcus aureus”. Journal of Herbal Medicine 18 (2021).
6. Sadik, A and Rifqah Amalia Anwar. "Therapeutic Properties of Centella asiatica's Leaves: A Comprehensive Review”. Journal of Medicinal Plants Research9 (2022).
7. Vinolina, V and Sigalingging, R. "Potential Growth of Centella asiatica (L.) Urban in Acidic Soil Conditions: A Case Study in Samosir, North Sumatra”. Journal of Agriculture and Natural Resources1 (2021).
8. Sakthipriya, V., et al. "Conservation and Genetic Diversity Analysis of Centella asiatica in India”. International Journal of Current Microbiology and Applied Sciences11 (2018).
9. Khotimah, R., et al. "Genetic Diversity Analysis and Conservation Strategies of Rare Centella asiatica Species”. Biodiversity and Conservation8 (2021).
10. Azad, M., et al. "Identification of Novel Compounds and Multitarget Inhibitors from Rare Centella asiatica Species”. Frontiers in Pharmacology 12 (2021).
11. Cahyaningsih Y., et al. "Utilization of DNA Barcoding in the Identification of Indonesian Medicinal Plant Species”. Indonesian Journal of Biotechnology1 (2022): 53-60.
12. Vu H N and Le H L. “Bioinformatics Tools for Species Identification Using DNA Sequences: A Comprehensive Review”. Journal of Computational Biology11 (2019): 1275-1285.
13. Shaukat S., et al. “Bioinformatics Tools and Techniques for DNA Sequence Analysis: A Comprehensive Review.”
14. Meiklejohn KA., et al. “Genome‐Wide DNA Barcoding: A High‐Resolution Tool for Ecological Studies and Applications”. Methods in Ecology and Evolution1 (2019): 38-48.
15. Doster E., et al. “Bioinformatic Tools for DNA Sequence Analysis: Methods and Applications”. Annual Review of Biomedical Data Science 2 (2019): 257-280.
16. Devkota M and Kumar Jha P. “Phenotypic plasticity and ecological differentiation in Centella asiatica (L.) Urban: a comparative analysis of populations from different habitats”. Botanical Studies1 (2019): 10.
17. Hagenbeek D., et al. “Genetic diversity and population structure in Centella asiatica (Apiaceae) based on metabolomic profiling”. Biochemical Systematics and Ecology 90 (2021): 104043.
18. Mohammad Azmin S A and Mat Nor M. “Solvent effect on extraction of bioactive compounds from Centella Asiatica”. Materials Today: Proceedings 22 (2020): 266-272.
19. Suprihatin S., et al. “Asiaticoside Content in Centella asiatica (L.) Urban: Influence of Genetic Diversity and Soil Conditions”. Journal of Agricultural Science1 (2023): 23-31.
20. Zhang WW., et al. “Genetic diversity analysis of wild Centella asiatica populations in China with inter-simple sequence repeat markers”. Biochemical Systematics and Ecology 45 (2012): 17-24.
21. Mathavaraj S and Sabu M. “Next-generation sequencing technology: transformative tool for genetic diversity analysis in Centella asiatica (L.) Urban”. Industrial Crops and Products, 160 (2021d): 113157.
22. Z Li., et al. “Population genetic differentiation of freshwater and coastal blue mussel populations in China using microsatellite markers”. Fisheries Science1 (2019): 285-295.
23. Mbinda W and Masaki K. “Molecular markers and marker-assisted selection in plant breeding: current status and future prospects”. Planta 3 (2021): 61.
24. Okwu M U and Ogbunugafor HA. “Methicillin-Resistant Staphylococcus aureus (MRSA): Prevalence, Consequences, and Challenges”. Journal of Microbiology Research and Reviews3 (2019): 1-15.
25. Radu S., et al. “MRSA Infections in Intensive Care Units: A Comprehensive Review”. International Journal of Infectious Diseases4 (2022): 567-580.
26. Stan R., et al. “Targeted Efficacy of Centella asiatica against Methicillin-Resistant Staphylococcus aureus: A Review”. Journal of Antibacterial Research2 (2021): 78-91.
27. Astiani A., et al. “Triterpene Saponins in Centella asiatica: Potential Antibacterial Agents against MRSA”. Journal of Natural Products Research5 (2023): 231-245.
28. Wong K Y and Ramli R. “Broad-Spectrum Antimicrobial Activity of Centella asiatica Extracts: MIC Values against Various Microorganisms”. Journal of Medicinal Plants Research4 (2021): 167-178.
29. Wei J., et al. “Madecassic Acid as an Anti-MRSA Drug: Mechanisms of Action and Efficacy”. Journal of Medical Chemistry2 (2023): 112-125.
30. Guglielmi P., et al. “Evaluation of Antimicrobial Effectiveness of Centella asiatica Extracts against MRSA: Methodologies and Techniques”. Journal of Microbiology and Antibacterial Research3 (2020): 189-201.
31. Qurrotuaini F., et al. “Testing Antimicrobial Activity in Centella asiatica Extracts: In Vitro Assay Protocols and Guidelines”. Journal of Clinical Microbiology and Immunology1 (2022).
32. Wong K Y and Ramli R. “Broad-Spectrum Antimicrobial Activity of Centella asiatica Extracts: MIC Values against Various Microorganisms”. Journal of Medicinal Plants Research4 (2021): 167-178.
33. Wald-Dickler N., et al. “Randomized Controlled Trials Evaluating Bactericidal vs. Bacteriostatic Agents in the Treatment of Bacterial Infections: A Review”. Journal of Clinical Pharmacology2 (2018): 89-102.
34. Han J., et al. “Antimicrobial Mechanisms of Known Antimicrobials: Insights from Recent Research”. Journal of Microbiology and Antibacterial Research, 45.3 (2019): 189-201.
35. Thiele-Bruhn S and Beck I C. “Exploring Antimicrobial Activity: A Review of Existing Literature”. Journal of Microbiology Research and Reviews3 (2005): 1-15.
36. SP Singh et al. “Large-Scale Cultivation of Rare Centella asiatica Species: A Strategy for Meeting Pharmaceutical Demand”. Journal of Pharmaceutical Sciences6 (2022): 312-325.
37. Rafi, M., et al. “Sustainable Cultivation Practices for Centella asiatica: A Review”. Journal of Sustainable Agriculture4 (2022): 231-245.
38. SP Singh., et al. “Large-Scale Cultivation of Rare Centella asiatica Species: A Strategy for Meeting Pharmaceutical Demand”. Journal of Pharmaceutical Sciences6 (2022): 312-325.
39. Singh R., et al. "The Effect of Production and Post-Harvest Processing Practices on Quality Attributes in Centella Asiatica (L.) Urban—A Review”. Agronomy8 (2023).
40. Ghoulem M., et al. "Greenhouse Design and Cooling Technologies for Sustainable Food Cultivation in Hot Climates: Review of Current Practice and Future Status”. Biosystems Engineering 183 (2019): 121-150.
41. Hernandez A G and Cullen JM. "Exergy: A Universal Metric for Measuring Resource Efficiency to Address Industrial Decarbonisation”. Sustainable Production and Consumption 20 (2019): 151-164.
42. Nordey T., et al. "Tapping the Potential of Grafting to Improve the Performance of Vegetable Cropping Systems in Sub-Saharan Africa: A Review”. (2022).
43. Müller, V., et al. "Centelloside Accumulation in Leaves of Centella Asiatica Is Determined by Resource Partitioning between Primary and Secondary Metabolism while Influenced by Supply Levels of Either Nitrogen, Phosphorus or Potassium”. Journal of Plant Physiology13 (2013): 1165-1175.
44. Yamaguchi K., et al. "Study of Triterpene Saponin Compounds from Centella Asitica as Renin Inhibitor with Pharmacophore Modeling, Molecular Docking and In-vitro Evaluation”. Pharmacognosy Journal1 (2023): 57-63.
45. Agosto Gomez L. "Growth Evaluation and Proximate Analysis of Gotu Kola (Centella Asiatica L.) in Response to Organic Growing Media Combinations”. Asian Journal of Fundamental and Applied Sciences2 (2021).
46. Hernandez A G and Cullen JM. "Exergy: A Universal Metric for Measuring Resource Efficiency to Address Industrial Decarbonisation”. Sustainable Production and Consumption 20 (2019): 151-164.
47. Nordey T., et al. "Tapping the Potential of Grafting to Improve the Performance of Vegetable Cropping Systems in Sub-Saharan Africa: A Review” (2020).
48. Sampantamit T., et al. "Aquaculture Production and Its Environmental Sustainability in Thailand: Challenges and Potential Solutions”. Sustainability5 (2020).

Citation

Citation: Lamlom Taie Lamlom Tahawy., et al. “Centella asiatica in Surakarta City, Indonesia: A Comprehensive Review of Discovery, Genetic Diversity, Antimicrobial Potential, and Cultivation".Acta Scientific Microbiology 7.7 (2024): 86-98.

Copyright

Copyright: © 2024 Lamlom Taie Lamlom Tahawy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.