Taliby Dos Camara^1,2*, Abdoulaye Makanera³, Fassou René Kolié^1,2, César Hagoussou¹, Nafisatou Sané^1,4 and Mariama Bah⁴

¹Microbiology Laboratory, Department of Biology, Faculty of Science, Gamal Abdel Nasser University, Conakry, Republic of Guinea
²Medical Biology Laboratory, Mahatma Gandhi University, Conakry, Republic of Guinea
³Laboratory of the Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University, Conakry, Republic of Guinea
⁴National Reference Laboratory for Mycobacteria at Ignace Deen University Hospital, Conakry, Republic of Guinea

*Corresponding Author: Taliby Dos Camara, Lecturer and Researcher, Microbiology Laboratory, Department of Biology, Faculty of Science, Gamal Abdel Nasser University, Conakry, Republic of Guinea.

Received: April 15, 2024; Published: June 24, 2024

Abstract

Introduction: Urinary tract infections are caused by the colonisation of the various organs of the urinary tract by micro-organisms. These infections can affect all parts of the urinary system.

Objective: To determine the prevalence of urogenital infections in women and the antibiotic susceptibility profile of the germs isolated, with a view to improving their management.

Methods: This was a prospective, descriptive longitudinal study conducted over three months, from1 May to 30 August 2023.

Results: Out of 150 urine samples analysed from women, the prevalence of urinary tract infections was 84%. Marital status showed that married women were the most affected by urinary tract infections, with a prevalence of 68%. Housewives were the most represented, at 37%, followed by commercial workers at 17%, administrative workers at 15%, and urinary tract infection patients from the Ratoma commune were the most represented, at 40%. A breakdown of patients by age showed that the 31-40 age group was the most affected (29%), followed by the 21-30 age group (24%) and those aged 61 and over (20%). The age groups least represented were 11-20, 41-50, 51-60 and 0-10 with 10%, 8%, 6% and 3% respectively. With regard to the macroscopic appearance of the urine of the 150 patients examined, 16% of the urine was clear, cloudy urine accounted for 45%, haematic urine for 3% and slightly cloudy urine for 36%. Cloudy urine means that it is potentially infected. Microscopic analysis showed that 15% of the urine was germ-free, while 63% contained gram-negative bacilli and 37% gram-positive cocci. According to cytology, leucocyturia was significant in 86% of infected urine samples. We also noted the presence of epithelial cells in 7%, haematuria in 2%, yeasts in 4% and oxalate crystals in 1%. The distribution of infected urine by germ species shows that E. coli is the most common germ, accounting for 26% of cases, followed by Staphylococcus aureus (14%), Proteus mirailus (9%), K. pneumoniae, Enterococcus spp. and Acidoacter bomani (8% each), Pseudomonas aeruginosae (7%) and other germs (between 1% and 3%). The antibiogram showed that of all the antibiotics used, three were effective against the germs responsible for urinary tract infections. Amikacin was effective in 44% of cases, Gentamycin in 39% and Tobramycin in 24%.

Conclusion: Urinary tract infections are a major health problem because of the bioresistance of germs, mainly in women, and antibiotic susceptibility testing is essential for their management.

Keywords: Urinary Tract Infections; Antibiotic Susceptibility Testing; Epidemiology; Women; CHU Ignace Deen; Conakry

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Citation

Citation: Taliby Dos Camara., et al. “Antibiotic Susceptibility Profile of Bacteria Responsible for Urogenital Infections and Epidemiology in Women at the Ignace Deen National Hospital in Conakry (Republic of Guinea)".Acta Scientific Microbiology 7.7 (2024): 63-75.

Copyright

Copyright: © 2024 Taliby Dos Camara., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.