Parna Gorai¹, Urmy Biswas² and Surojit Das²*

¹Clinical, Nutrition and Dietetics, Vidyasagar University, Midnapore, West Bengal, India
²Biomedical Laboratory Science and Management, Vidyasagar University, Midnapore, West Bengal, India

*Corresponding Author: Surojit Das, Assistant Professor, Biomedical Laboratory Science and Management, Vidyasagar University, Midnapore, West Bengal, India.

Received: May 24, 2024; Published: June 19, 2024

Abstract

Antibiotic resistance (ABR) is a major global public health problem. However, emerging hospital and community-based data indicated a rise in the prevalence of antibiotic resistance in developing low and middle-income (LMIC) countries like India. Determining antibiotic use, the causes and evolution of antibiotic resistance, regional variations, and interventional techniques tailored to each nation is challenging. ABR in Escherichia coli (E. coli) is a common problem in the twenty-first century, mostly seen in humans, animals, poultry, and the environment. The majority of antibiotic-resistant genes that E. coli obtains are through horizontal gene transfer. The most problematic mechanisms observed in E. coli are associated with the acquisition of genes encoding for carbapenemases, plasmid-mediated quinolone resistance, 16S rRNA methylases, Extended spectrum β-lactamases (ESBL), and mcr genes. E. coli is primarily isolated from clinical isolates that are resistant to antimicrobial drugs such as carbapenems, fluoroquinolones, co-trimoxazole, aminoglycosides, and nitrofurantoin, but E. coli of animal origin often resists these drugs. However, resistance to tetracyclines, phenicols, sulfonamides, trimethoprim, and fosfomycinis mostly noted in animal isolates. The resistance to trimethoprim-sulfamethoxazole, amoxicillin, penicillins, ampicillin, tetracycline, aminoglycosides, etc. is higher in the environmental samples. E. coli serves as a sensor for integrated antibiotic resistance screening. The purpose of this study was to investigate the role of E. coli as an ABR marker in the public health concern. The findings of the study could shed the spotlight on the wide range of E. coli strains and strengthen infection prevention and control protocols.

Keywords: Escherichia coli; Antibiotic Resistance (ABR); Indicator; β-lactam Antimicrobials; Surveillance

References

1. Global antimicrobial resistance surveillance system (GLASS) report: early implementation 2016-2017 ISBN 978-92-4-151344-9 © World Health Organization (2017).
2. World Health Organization WHO global strategy for containment of antimicrobial resistance. Geneva: WHO (2023).
3. O’Neill J. “Tackling drug-resistant infections globally: final report and recommendations” (2016).
4. World Health Organization WHO global strategy for containment of antimicrobial resistance. Geneva: WHO (2001).
5. World Health Organization The evolving threat of antimicrobial resistance. Options for action. Geneva: WHO Library Cataloguing-in-Publication Data; (2012).
6. Prestinaci F., et al. “Antimicrobial resistance: a global multifaceted phenomenon”. Pathogen and Global Health7 (2015): 309-318.
7. World Health Organization Antimicrobial resistance: global report on surveillance 2014. Geneva, Switzerland: WHO; (2014).
8. Rasheed M U T., et al. “Antimicrobial drug resistance in strains of Escherichia coli isolated from food sources”. Revista do Instituto de Medicina Tropical de Sao Paulo 56.4 (2014): 341-346.
9. Rodrigo Luis. “E. Coli Infections - Importance of Early Diagnosis and Efficient Treatment || Antimicrobial Resistance in Escherichia coli”. Chapter metrics overview 9 (2020).
10. Williams-Nguyen J., et al. “Antibiotics and Antibiotic Resistance in Agroecosystems: State of the Science”. Journal of Environmental. Quality 45 (2016): 394-406.
11. Salam MA Al., et al. “Antimicrobial Resistance: A Growing Serious Threat for Global Public Health”. Healthcare 13 (2023): 1946.
12. Alali WQ., et al. “Prevalence of antimicrobial resistance in Gram-negative clinical isolates from a major secondary hospital in Kuwait: a retrospective descriptive study”. Germs 4 (2021): 498-511.
13. Hossain A., et al. “Age and gender-specific antibiotic resistance patterns among Bangladeshi patients with urinary tract infection caused by Escherichia coli”. Heliyon6 (2020): e04161.
14. Jaggi N., et al. “Carbapenem resistance in Escherichia coli and Klebsiella pneumoniae among Indian and international patients in North India”. Acta Microbiologica et Immunologica Hungarica3 (2019): 367-376.
15. World Health Organisation. Antimicrobial Resistance: Briefing to WHO Member States (2023).
16. Blount ZD. “The unexhausted potential of E. Coli”. Elife 4 (2015): e05826.
17. Jang J., et al. “Environmental Escherichia coli: ecology and public health implications—a review”. Journal of Applied Microbiology 123 (2017): 570-581.
18. Sarowska J., et al. “Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports”. Gut Pathogen 11 (2019): 10.
19. Johnson JR K., et al. “Antimicrobial-resistant and extraintestinal pathogenic Escherichia coli in retail foods”. Journal of Infectious Diseases7 (2005): 1040-1049.
20. Poirel L M., et al. “Antimicrobial Resistance in Escherichia coli”. Microbiology Spectrctum4 (2018).
21. Jafari A., et al. “Escherichia coli: a brief review of diarrheagenic pathotypes and their role in diarrheal diseases in Iran”. Iranian journal of Microbiology3 (2012): 102-117.
22. Carlos C P., et al. “Escherichia coli phylogenetic group determination and its application in the identification of the major animal source of faecal contamination”. BMC Microbiology 10 (2010): 161.
23. Staji H R., et al. “Comparative virulotyping and phylogenomics of Escherichia coli isolates from urine samples of men and women suffering urinary tract infections”. Iranian Journal of Basic Medical Sciences 2 (2019): 211-214.
24. Manges AR. “Escherichia coli and urinary tract infections: the role of poultry-meat”. Clinical Microbiology Infection 22 (2016): 122-129.
25. Rodriguez-Siek KEG., et al. “Comparison of Escherichia coli isolates implicated in human urinary tract infection and avian colibacillosis”. Microbiology Reading 151 (2005): 2097-20110.
26. Baldy-Chudzik K B., et al. “Well-known and new variants of pathogenic Escherichia coli as a consequence of the plastic genome”. Postepy Hig med Dosw 69 (2015): 345-361.
27. Wirth T F., et al. “Sex and virulence in Escherichia coli: an evolutionary perspective”. Molecular Microbiology5 (2006): 1136-1151.
28. Rogers BA S., et al. “Escherichia coli O25b-ST131: a pandemic, multiresistant, community-associated strain”. Journal of Antimicrobial Chemotherapy1 (2011): 1-14.
29. Johnson JRS., et al. “Antimicrobial drug-resistant Escherichia coli from humans and poultry products, Minnesota and Wisconsin, 2002-2004”. Emerging Infectious diseases6 (2007): 838-46.
30. Rothrock MJ H., et al. “Antibiotic Resistance Patterns of Major Zoonotic Pathogens from All-Natural, Antibiotic-Free, Pasture-Raised Broiler Flocks in the Southeastern United States”. Journal of Environmental Quality2 (2016): 593-603.
31. Johnson JR k., et al. “Antimicrobial-resistant and extraintestinal pathogenic Escherichia coli in retail foods”. Journal of Infectious Disease7 (2005): 1040-1049.
32. Song L., et al. “Investigation of integrons/cassettes in antimicrobial-resistant Escherichia coli isolated from food animals in China”. Science China Life Science5 (2010): 613-619.
33. Song LN., et al. “Investigation of integrons/cassettes in antimicrobial-resistant Escherichia coli isolated from food animals in China”. Science China Life Sciences 5 (2010): 613-619.
34. Chen X Zh., et al. “Escherichia coli isolates from sick chickens in China: changes in antimicrobial resistance between 1993 and 2013”. Veterinary Journal1 (2014): 112-115.
35. Ryu SH L., et al. “Antimicrobial resistance profiles among Escherichia coli strains isolated from commercial and cooked foods”. International Journal of Food Microbiology 3 (2012): 263-266.
36. Lim SK K., et al. “First Detection of the mcr-1 Gene in Escherichia coli Isolated from Livestock between 2013 and 2015 in South Korea”. Antimicrobe Agents Chemotherapy11 (2016): 6991-6993.
37. Bista Sayara., et al. “Detection of plasmid-mediated colistin resistant mcr-1 gene in Escherichia coli isolated from infected chicken livers in Nepal”. Animals11 (2020): 2060.
38. Md Saiful Islam., et al. “A Systematic Review on the Occurrence of Antimicrobial-Resistant Escherichia coli in Poultry and Poultry Environments in Bangladesh between 2010 and 2021”. BioMed Research International 2425564 (2018): 18.
39. Sarker M., et al. “Antibiotic resistance of Escherichia coli isolated from broilers sold at live bird markets in Chattogram, Bangladesh”. Journal of Advanced Veterinary And Animal Research2 (2019): 272-277.
40. Tanzin T N., et al. “Antibiotic resistance profile of bacteria isolated from raw milk samples of cattle and buffaloes”. Journal Of Advanced Veterinary and Animal Research1 (2016): 62-67.
41. Parvin MS T., et al. “Antimicrobial Resistance Pattern of Escherichia coli Isolated from Frozen Chicken Meat in Bangladesh”. Pathogens6 (2020): 420.
42. Nahar I., et al. “Molecular characterization and antibiotic resistance profile of ESBL-producing Escherichia coli isolated from healthy cow raw milk in smallholder dairy farms in Bangladesh”. Veterinary World6 (2023): 1333-1339.
43. Batabyal K B., et al. “Detection, characterization, and antibiogram of extended-spectrum beta-lactamase Escherichia coli isolated from bovine milk samples in West Bengal, India”. Veterinary World10 (2018): 1423-1427.
44. Mahanti A., et al. “Milk from healthy or infected cattle as a source of multi-drug resistant, AmpC β- lactamase-producing Escherichia coli”. Indian Journal of Dairy Science4 (2020): 343-347.
45. Bhattacharya C., et al. “Detection of extended spectrum beta lactamase (ESBL) producing bacteria from meat and meat products in Kolkata, India”. IOSR JDMS8 (2015): 52-55.
46. Khyati Bhardwaj S., et al. “Characterization of antibiotic resistant phenotypes and linked genes of Escherichia coli and Klebsiella pneumoniae from healthy broiler chickens, Karnataka, India”. Poultry Science6 (2021): 101094.
47. Tumlam UM P., et al. “Phylogenetic Analysis and Antimicrobial Resistance of Escherichia coli Isolated from Diarrheic Piglets”. Indian Journal of Veterinary Sciences and Biotechnology3 (2022): 119-121.
48. , et al. “Multiple Antimicrobial Resistance and Novel Point Mutation in Fluoroquinolone-Resistant Escherichia coli Isolates from Mangalore, India”. Microbial Drug Resistance 23.8 (2017): 994-1001.
49. Hussain A., et al. “Risk of Transmission of Antimicrobial Resistant Escherichia coli from Commercial Broiler and Free-Range Retail Chicken in India”. Frontiers in Microbiology 8 (2017): 2120.
50. Karlowsky JAK., et al. “Trends in antimicrobial resistance among urinary tract infection isolates of Escherichia coli from female outpatients in the United States". Antimicrobial agents and chemotherapy 8 (2002): 2540-2545.
51. Reynolds R., et al. “Antimicrobial susceptibility of the pathogens of bacteraemia in the UK and Ireland 2001-2002: the BSAC Bacteraemia Resistance Surveillance Programme”. Journal of Antimicrobial Chemotherapy 6 (2004): 1018-1032.
52. George G Zhanel T., et al. “Antibiotic resistance in Escherichia coli outpatient urinary isolates: final results from the North American Urinary Tract Infection Collaborative Alliance (NAUTICA)”. International Journal of Antimicrobial Agents6 (2006): 468-475.
53. Fluit A CJ., et al. “Antimicrobial Susceptibility and Frequency of Occurrence of Clinical Blood Isolates in Europe from the SENTRY Antimicrobial Surveillance Program, 1997 and 1998”. Clinical Infectious Diseases 30.3 (2000): 454-460.
54. Til Stürmer A., et al. “Prevalence and determinants of antibiotic resistance in faecal Escherichia coli among unselected patients attending general practitioners in Southwest Germany”. Pharmacoepidemolgy and Drug safety5 (2004): 303-308.
55. Domínguez E Z., et al. “Mechanisms of antibiotic resistance in Escherichia coli isolates obtained from healthy children in Spain". Microbial Drug Resistant4 (2002): 321-327.
56. Oteo J L., et al. “Antimicrobial-resistant invasive Escherichia coli, Spain”. Emerging infectious diseases 4 (2005): 546-553.
57. Kim Jin Seok Han., et al. “Identification of an extensively drug-resistant Escherichia coli clinical strainharboring mcr-1 and blaNDM-1 in Korea”. The Journal of Antibiotics 73 (2020): 852-858.
58. Zhang W W., et al. “Comparison of Epidemiological Characteristics Between ESBL and Non-ESBL Isolates of Clinically Isolated Escherichia coli from 2014 to 2022: A Single-Center Study”. Infectious Drug Resistant 16 (2023): 5185-5195.
59. Jain P., et al. “High prevalence of multiple antibiotic resistance in clinical E. Coli isolates from Bangladesh and prediction of molecular resistance determinants using WGS of an XDR isolate”. Scientific Reports 11 (2021): 22859.
60. VV Borah K., et al”. New Delhi metallo-β-lactamase and extended spectrum β-lactamases co-producing isolates are high in community-acquired urinary infections in Assam as detected by a novel multiplex polymerase chain reaction assay, Indian” Journal of Medical Microbiology2 (2016): 173-182.
61. Jyoti Sharma M., et al. “Prevalence and antibiotic susceptibility pattern of multi-drug resistant Escherichia coli isolates from urinary tract infection (UTI) patients”. International Journal of Life Sciences and Pharma Research4 (2012): 6-11.
62. Rajdeep Saha A., et al. “Quinolone Resistant E. Coli - A Silent Invader in Elderly Patients: A Study from Eastern India”. Journal of Evolution of Medical and Dental Sciences55 (2014) :12577-12583.
63. Seidman JC A., et al. “Risk factors for antibiotic-resistant E. Coli in children in a rural area”. Epidemiology and Infection6 (2009): 879-888.
64. Roy Subhasree., et al. “Prevalence of ST131 virulence-associated strains among CTX-M-producing Escherichia coli in the gut of hospitalized neonates in India”. Diagnostic Microbiology and Infectious Disease 2 (2013): 158-159.
65. E Amaya., et al. “Antibiotic resistance patterns of Escherichia coli isolates from different aquatic environmental sources in León, Nicaragua”. Clinical Microbiology and Infection9 (2012): E347-E354.
66. Bojar B S., et al. “Antibiotic resistance patterns of Escherichia coli isolates from the clinic through the wastewater pathway”. International Journal of Hygiene and Environmental Health 238 (2021): 113863.
67. Mbanga J K., et al. “Antibiotic resistance, pathotypes, and pathogen-host interactions in Escherichia coli from hospital wastewater in Bulawayo, Zimbabwe". PLoS One3 (2023): e0282273.
68. Reinthaler FF P., et al. “Antibiotic resistance of E. Coli in sewage and sludge”. Water Research8 (2003): 1685-1690.
69. Kotlarska E., et al. “Antibiotic resistance and prevalence of class 1 and 2 integrons in Escherichia coli isolated from two wastewater treatment plants, and their receiving waters (Gulf of Gdansk, Baltic Sea, Poland)”. Environmental Science and Pollution Research 3 (2015): 2018-2030.
70. Delgado-Blas JF., et al. “Population genomics and antimicrobial resistance dynamics of Escherichia coli in wastewater and river environments”. Communication Biology457 (2021).
71. Hu JS., et al. “Phenotyping and genotyping of antibiotic-resistant Escherichia coli isolated from a natural river basin”. Environment Sciences Technology9 (2008): 3415-3420.
72. Li Q C., et al. “The Role of Plasmids in the Multiple Antibiotic Resistance Transfer in ESBLs-Producing Escherichia coli Isolated from Wastewater Treatment Plants”. Frontiers in Microbiology 10 (2019): 633.
73. Akther S., et al. “Multidrug Resistant E. Coli in Hospital Waste Water: A Potential Concern for Public Health”. Advances in Biotechnology and Microbiology1 (2018).
74. Giri N., et al. “Antibiotic resistance of Escherichia coli isolated from Lake Nainital, Uttarakhand State, India”. Journal of Mountain Research1 (2021): 127-136.
75. Biswas U., et al. “Global Emergence of mcr-mediated Colistin Resistance in Gram-negative Bacteria: Focusing the Current Status in India Under One Health Lens”. RRJoMV 12 (2023): 6-18.

Citation

Citation: Surojit Das., et al. “Escherichia coli, as the Indicator Microorganism of Antibiotic Resistance Across Human-animal-Environmental Interfaces". Acta Scientific Microbiology 7.7 (2024): 38-50.

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Copyright: © 2024 Surojit Das., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.