Neha, Chauhan S and Negi DS

Department of Biotechnology, Himachal Pradesh University, India

*Corresponding Author: Neha, Department of Biotechnology, Himachal Pradesh University, India.

Received: February 19, 2024; Published: February 28, 2024

Abstract

The prevalence of multidrug-resistant (MDR) bugs has evolved as a significant global health concern worldwide. The escalating prevalence of multidrug resistant (MDR) pathogens is concerning, emphasizing the significance of developing novel and innovative antimicrobial therapies. The use of plant-based pharmaceuticals is increasingly growing as a safer, simple, affordable and chemical free substitute. Consequently, numerous research laboratories are actively engaged in the exploration of novel biologically active compounds with antimicrobial potential. Ricinus communis is one such important medicinal herb renowned for its significant amounts of flavonoids, phenols and tannins etc. The antibacterial efficacy of methanol and hydro-alcohol crude leaves concentrates of R. communis was determined against P. vulgaris (MTCC 1771), S. pyogenes (MTCC 442), B. subtilus (MTCC 441), S. aureus (MTCC 96) using agar well diffusion assay. Keeping in view the potential of Ricinus communis, the current research aimed to investigate, qualitative phytochemicals assessment and antimicrobial efficacy. Therefore, this study reveals that R. communis extracts contain a variety of chemical components linked to their antimicrobial properties giving a maximum Zone of Inhibition (ZOI) by Methanolic concentrate in comparison to the Hydro-alcoholic extract.

Keywords: Ricinus communis; Phytochemicals; Multidrug Resistance; Zone of Inhibition; P. vulgaris; S. pyogenes; B. subtilus; S. aureus; ZOI

References

1. Kebede B and Shibeshi W. “In vitro antibacterial and antifungal activities of extracts and fractions of leaves of Ricinus communis Linn against selected pathogens”. Veterinary Medicine and Science4 (2022): 1802-1815.
2. Berhe DF., et al. “Prevalence of antimicrobial resistance and its clinical implications in Ethiopia: A systematic review”. Antimicrobial Resistance and Infection Control 10 (2021): 168.
3. Bedasa S., et al. “Occurrence and antimicrobial susceptibility profile of Escherichia coli0157:H7 from food of animal origin in Bishoftu town, central Ethiopia”. International Journal of Food Contamination 5 (2018): 2.
4. Helmenstine AM. “List of medicines made from plants”. Thought Co. (2021).
5. Neelam G and Singh AK. “A review on Ricinus communis Linn”. International Ayurvedic Medical Journal2 (2015): 492-495.
6. Suurbaar J., et al. “Antibacterial and antifungal activities and phytochemical profile of leaf extract from different extractants of Ricinus communis against selected pathogens”. BioMed Central 10 (2017): 660.
7. Naz R and Bano A. “Antimicrobial potential of Ricinus communis leaf extracts in different solvents against pathogenic bacterial and fungal strains”. Asian Pacific Journal of Tropical Biomedicine12 (2012): 944–947.
8. Liu WJ et al. “Chemical constituents from Agrimonia pilosa Ledeb. and their chemotaxonomic significance”. Natural Product Research21 (2016): 2495-2499.
9. Raaman N. “Phytochemical techniques”. New India Publishing 1 (2006): 19-25.
10. De Silva., et al. “Extraction methods, qualitative and quantitative techniques for screening of phytochemicals from plants”. American Journal of Essential Oils and Natural Products2 (2017): 29-32.
11. Tiwari P., et al. “Phytochemical screening and extraction: A review”. Internationale Pharmaceutica Sciencia1 (2011): 98- 106.
12. Saxena M., et al. “Phytochemistry of medicinal plants”. Journal of Pharmacognosy and Phytochemistry6 (2013): 168-182.
13. Banu KS and Cathrine L. “General techniques involved in Phytochemical analysis”. International Journal of Advanced Research in Chemical Science4 (2015): 25-32.
14. Parekh J and Chanda S. “In vitro antimicrobial activity and phytochemical analysis of some Indian medicinal plants”. Turkish Journal of Biology1 (2007): 53-58.
15. Othman M., et al. “Optimal methods for evaluating antimicrobial activities from plant extracts”. Journal of Microbiological Methods 2 (2011): 161-166.
16. Chandrasekaran M and Venkatesalu V. “Antibacterial and antifungal activity of Syzygiumjambolanum seeds”. Journal of Ethnopharmacology 91 (2004): 105-108.
17. Ashafa AOT., et al. “Antimicrobial activity of extract from Felicia muricata Thunb”. Journal of Biological Sciences6 (2008): 1062-1066.
18. Olayinka AT., et al. “Prevalence of multidrugresistance (MDR) Pseudomonas aeruginosa isolates in surgical units of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria: An indication for effective control measures”. Annals of African Medicine1 (2004): 13-16.
19. Taiwo SS., et al. “In vitro antimicrobial susceptibility pattern of bacterial isolates from wound infections in University of Ilorin Teaching Hospital”. African Journal of Clinical and Experimental Microbiology 1 (2002): 6-10.

Citation

Citation: Neha., et al. “Qualitative Phytochemicals Analysis and In vitro Antibacterial Efficacy of Methanolic and Hydroalcoholic Ricinus communis L. Leaves Extracts".Acta Scientific Microbiology 7.3 (2024): 101-106.

Copyright

Copyright: © 2024 Neha., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.