Umakanthan¹*, Madhu Mathi², Umadevi³ and Sivaramakrishnan⁴

¹Veterinary Hospital, Gokulam Annadhanam Temple Complex, Tamil Nadu, India
²Veterinary Hospital, Vadakupudhu Palayam Post, Tamil Nadu, India
³Assistant Professor, Department of Botany, The Standard Fireworks Rajaratnam College for Women, Sivakasi, Virudhunagar (Dt), Tamil Nadu, India
⁴Veterinary Assistant Surgeon, Veterinary Dispensary, Tamil Nadu, India

*Corresponding Author: Umakanthan, Veterinary Hospital, Gokulam Annadhanam Temple Complex, Tamil Nadu, India.

Received: November 27, 2023; Published: January 25, 2024

Abstract

Antimicrobial potentiation can reduce dosage and cost while also reducing host stress. In general, potentiation is achieved to some extent through the combination of antimicrobials, but it is not always beneficial, particularly due to concerns about multi-drug resistance and economic issues. To favorably overcome these issues, we developed an approach in which irradiation with non-ionizing 2-6 μm mid-infrared (mid-IR) light increased the potency of antibiotics by severalfold. Different groups of antibiotics were treated with 2-6 μm mid-IR and challenged with different pathogens. We observed that antibiotic potency was enhanced by 5-173%. We developed a mid-infrared-generating atomizer (MIRGA). Through the agar well-diffusion method, a sensory expert panel test, and a variety of instrumentations, we deciphered that the mid-IR’s effect on the irradiated antibiotics included changes in chemical bonding, configuration, atomic arrangement, and chemical compounds that are responsible for the enhanced potentiation. This technique is found to be safe, easily applicable, and economical, with a vast scope for the future potentiation of other pharmacological compounds as well.

Keywords: Antibiotics; 2-6 μm Mid-Infrared; Antibiotics Potentiation; Enhancement; Economy; Safe

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Citation

Citation: Umakanthan., et al. “Mid-infrared - A Laser Potentiator to Enhance the Potency of Antibiotics In Vitro".Acta Scientific Microbiology 7.2 (2024): 106-117.

Copyright

Copyright: © 2024 Umakanthan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.