Acta Scientific Microbiology

Review Article Volume 7 Issue 2

Impact of Anemia in Development of Infants: A Review

Harshit Thakur1, Archita Kansal Tiwari2, Akash Kumar1*, Pankaj Kishor Mishra1 and Umesh Kumar1

1Department of Paramedical Sciences, Subharti Medical College, Swami Vivekananda Subharti University, Meerut, India
2Department of Pathology, Subharti Medical College, Swami Vivekananda Subharti University, Meerut, India

*Corresponding Author: Harshit Thakur, Department of Paramedical Sciences, Subharti Medical College, Swami Vivekananda Subharti University, Meerut, India.

Received: December 20, 2023; Published: January 22, 2024


Anemia is a global public health issue that affects roughly one-third of the world's population. Anemia causes both short-term and long-term devastating complications in infants and children. Despite the fact that anaemia is a major public health concern, newborns, particularly in developing countries, are frequently overlooked and undiagnosed. It is a condition where the amount of red blood cells or the amount of haemoglobin they contain is below normal. There will be a reduced ability of the blood to transfer oxygen to the body's tissues if you have insufficient or atypical red blood cells, insufficient haemoglobin, or both. Nutritional deficiencies, particularly iron deficiency, are the most frequent causes of anaemia, though deficiencies in folate, vitamins B12, and A are also significant contributors.
The important public health issue of anaemia disproportionately affects young children. According to WHO statistics, anaemia affects 40% of pregnant women and 42% of children under the age of five worldwide. Iron deficiency is common among infants and young children, particularly in developing countries.
Despite iron repletion, animal models show that iron deficiency during the brain growth spurt alters metabolism and neurotransmission, myelination, and gene and protein profiles. In humans, there is compelling evidence that 6- 24-month-old infants with iron deficiency anaemia have poorer short and long term cognitive, motor, social-emotional, and neurophysiologic development.
In contrast to the inconsistent developmental effects of iron therapy for iron deficient infants, recent large, randomized trials of iron supplementation in developing countries consistently show iron benefits, particularly on motor development and social emotional behaviour. These findings suggest that iron can be used to prevent and or reverse negative effects earlier in development or before iron deficiency occurs.

Keywords: Anemia; Red Blood Cells; Hemoglobin


  1. Milman N. “Anemia--still a major health problem in many parts of the world!”. Annals of Hematology4 (2011): 369-377.
  2. Bathla S and Arora S. “Prevalence and approaches to manage iron deficiency anemia (IDA)”. Critical Reviews in Food Science and Nutrition32 (2022): 8815-8828.
  3. Nagao T and Hirokawa M. “Diagnosis and treatment of macrocytic anemias in adults”. Journal of General and Family Medicine5 (2017): 200-204.
  4. Tiruneh T., et al. “Prevalence and associated factors of anemia among full-term newborn babies at University of Gondar comprehensive specialized hospital, Northwest Ethiopia: a cross-sectional study”. Italian Journal of Pediatrics1 (2020): 1.
  5. Dereje I., et al. “Prevalence of Anemia and Associated Factors Among Term Newborns in Nekemte Specialized Hospital, Western Ethiopia”. Journal of Multidisciplinary Healthcare 14 (2021): 2607-2615.
  6. Kalteren W S., et al. “Anemia and Red Blood Cell Transfusions, Cerebral Oxygenation, Brain Injury and Development, and Neurodevelopmental Outcome in Preterm Infants: A Systematic Review”. Frontiers in Pediatrics 9 (2021): 644462.
  7. Rocha G., et al. “Early anemia and neonatal morbidity in extremely low birth-weight preterm infants”. The Journal of Maternal-Fetal and Neonatal Medicine : The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians22 (2021): 3697-3703.
  8. Joo EY., et al. “Iron deficiency anemia in infants and toddlers”. Blood Research 51 (4 (2016): 268-273.
  9. Means R T. “Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters”. Nutrients2 (2020): 447.
  10. Wood S K and Sperling R. “Pediatric Screening: Development, Anemia, and Lead”. Primary care1 (2019): 69-84.
  11. Moscheo C., et al. “New Insights into Iron Deficiency Anemia in Children: A Practical Review”. Metabolites4 (2020): 289.
  12. Nazari M., et al. “Prevalence of iron deficiency anemia in Iranian children under 6 years of age: a systematic review and meta-analysis”. Journal of Blood Medicine 10 (2019): 111-117.
  13. Abu-Ouf N M and Jan M M. “The impact of maternal iron deficiency and iron deficiency anemia on child's health”. Saudi Medical Journal 2 (2015): 146-149.
  14. Colombatti R., et al. “Anemia and transfusion in the neonate”. Seminars in Fetal and Neonatal Medicine 1 (2016): 2-9.
  15. Melku M., et al. “Male and undernourished children were at high risk of anemia in Ethiopia: a systematic review and meta-analysis”. Italian Journal of Pediatrics 44 (1 (2018): 1-11.
  16. Kassebaum N J and GBD 2013 Anemia Collaborators. “The global burden of anemia”. Hematology/oncology clinics of North America 2 (2016): 247-308.
  17. Wong C. “Iron deficiency anaemia”. Paediatrics and Child Health 11 (2017): 527-529.
  18. K T N., et al. “Analysis of red blood cells from peripheral blood smear images for anemia detection: a methodological review”. Medical and Biological Engineering and Computing9 (2022): 2445-2462.
  19. Camaschella C. “Iron-deficiency anemia”. New England Journal of Medicine19 (2015): 1832-1843.
  20. Miller J L. “Iron deficiency anemia: a common and curable disease”. Cold Spring Harbor Perspectives in Medicine7 (2013): a011866.
  21. Cappellini M D and Motta I. “Anemia in Clinical Practice-Definition and Classification: Does Hemoglobin Change With Aging?” Seminars in Hematology4 (2015): 261-269.
  22. McGann PT., et al. “Current management of sickle cell anemia”. Cold Spring Harbor Perspectives in Medicine8 (2013): a011817.
  23. Williams TN and Thein SL. “Sickle Cell Anemia and Its Phenotypes”. Annual Review of Genomics and Human Genetics 19 (2018): 113-147.
  24. Schoettler M L and Nathan DG. “The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited”. Hematology/Oncology Clinics of North America4 (2018): 581-594.
  25. Cao A and Galanello R. “Beta-thalassemia”. Genetics In Medicine : Official Journal of the American College of Medical Genetics2 (2010): 61-76.
  26. Galanello R and Origa R. “Beta-thalassemia”. Orphanet Journal of Rare Diseases 5 (2010): 11.
  27. Rachmilewitz E A and Giardina P J. “How I treat thalassemia”. Blood 13 (2011): 3479-3488.
  28. Peslak SA., et al. “Diagnosis and Treatment of Aplastic Anemia”. Current Treatment Options in Oncology12 (2017): 70.
  29. Hartung H D., et al. “Acquired aplastic anemia in children”. Pediatric Clinics of North America6 (2013): 1311-1336.
  30. Lum S H and Grainger J D. “Eltrombopag for the treatment of aplastic anemia: current perspectives”. Drug Design, Development and Therapy 10 (2016): 2833-2843.
  31. Young N S. “Aplastic Anemia”. The New England Journal of Medicine17 (2018): 1643-1656.
  32. Bacigalupo A. “How I treat acquired aplastic anemia”. Blood11 (2017): 1428-1436.
  33. DeZern AE and Churpek J E. “Approach to the diagnosis of aplastic anemia”. Blood Advances12 (2021): 2660-2671.
  34. Toh BH. “Pathophysiology and laboratory diagnosis of pernicious anemia”. Immunologic Research 1 (2017): 326-330.
  35. Banka S., et al. “Pernicious anemia - genetic insights”. Autoimmunity Reviews8 (2011): 455-459.
  36. Socha D S., et al. “Severe megaloblastic anemia: Vitamin deficiency and other causes”. Cleveland Clinic Journal Of Medicine3 (2020): 153-164.
  37. Black M M., et al. “Iron deficiency and iron-deficiency anemia in the first two years of life: strategies to prevent loss of developmental potential”. Nutrition Reviews 69 (2011): S64-S70.
  38. McCann S., et al. “The Role of Iron in Brain Development: A Systematic Review”. Nutrients7 (2020): 2001.
  39. Lu J and Claud EC. “Connection between gut microbiome and brain development in preterm infants”. Developmental Psychobiology5 (2019): 739-751.
  40. Lin L., et al. “Impact of macronutrient supplements on later growth of children born preterm or small for gestational age: A systematic review and meta-analysis of randomised and quasirandomised controlled trials”. PLoS Medicine5 (2020): e1003122.
  41. Quelhas D., et al. “The association between active tobacco use during pregnancy and growth outcomes of children under five years of age: a systematic review and meta-analysis”. BMC Public Health1 (2018): 1372.
  42. Laron Z., et al. “Head circumference in untreated and IGF-I treated patients with Laron syndrome: comparison with untreated and hGH-treated children with isolated growth hormone deficiency. Growth hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society2 (2012): 49-52.
  43. German K R and Juul SE. “Iron and Neurodevelopment in Preterm Infants: A Narrative Review. Nutrients11 (2021): 3737.
  44. Pala E., et al. “Psychomotor development in children with iron deficiency and iron-deficiency anemia”. Food and Nutrition Bulletin3 (2010): 431-435.
  45. Cibulskis CC., et al. “Anemia of prematurity: how low is too low?”. Journal of Perinatology : Official Journal of the California Perinatal Association6 (2021): 1244-1257.
  46. Farias PM., et al. “Minerals in Pregnancy and Their Impact on Child Growth and Development”. Molecules (Basel, Switzerland 25.23) (2020): 5630.
  47. DeLoughery T G. “Microcytic anemia”. The New England Journal of Medicine14 (2014): 1324-1331.
  48. Fenton T R., et al. “Preterm Infant Growth Velocity Calculations: A Systematic Review”. Pediatrics3 (2017): e20162045.


Citation: Harshit Thakur., et al. “Impact of Anemia in Development of Infants: A Review".Acta Scientific Microbiology 7.2 (2024): 79-85.


Copyright: © 2024 Harshit Thakur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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