Acta Scientific Microbiology

Review Article Volume 7 Issue 1

Molecular Detection of INH Susceptibility is also Required for Improved Performance in Pulmonary Tuberculosis

Amit Singh, Sohini Sengupta and Ashok Rattan*

Redcliffe National Reference Laboratory, Noida, India

*Corresponding Author: Ashok Rattan, Professor, Redcliffe National Reference Laboratory, Noida, India.

Received: November 23, 2023; Published: December 29, 2023

Abstract

Diagnosis is the weakest link in our efforts to eliminate Tuberculosis. If detected early, screened for drug resistance and fully treated with appropriate multidrug regimen, TB can be cured. The diagnostic methods since 1882 had been smear microscopy. Subsequently culture was added to the diagnostic modalities. While smear was insensitive needing atleast 10,000 bacteria for reliable detection, culture was slow, taking weeks. The assessment and recommendation of Gene Xpert, a cartridge based molecular method which not only detected MTBC but also reported on Rifampicin susceptibility was a major improvement. Initially Rif resistant was thought to be a good surrogate marker for MDR TB. Recent evidence indicate that was not correct and may have been counter productive. If the isolate was INH susceptible but Rif mono resistance and as per recommendation treated as MDR TB, then INH, an excellent bactericidal drug would have been with-held. On the other hand if INH monoresistant (IMR) was present and patient was treated with standard regimen, then for four months in the continuation phase, patient would receive monotherapy which would encourage emergence of MDR TB, failure of treatment, relapse or death.

Keywords: Diagnosis; WHO; MTBC

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Citation

Citation: Ashok Rattan., et al. “Molecular Detection of INH Susceptibility is Also Required for Improved Performance in Pulmonary Tuberculosis".Acta Scientific Microbiology 7.1 (2024): 82-88.

Copyright

Copyright: © 2024 Ashok Rattan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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