Acta Scientific Microbiology

Review Article Volume 7 Issue 1

Antibiotic and Immunological Alternatives for the Management of Clostridioides difficile Infection

Gian Carlo González-Carballo*

Clinical Laboratory of the Dr. R. A. Calderón Guardia Hospital, Costa Rica´s Social Security, San José, Costa Rica

*Corresponding Author: Gian Carlo González-Carballo, Clinical Laboratory of the Dr. R. A. Calderón Guardia Hospital, Costa Rica´s Social Security, San José, Costa Rica.

Received: December 08, 2023; Published: December 29, 2023


Clostridioides difficile is one of the most important healthcare-associated pathogens in both developed and developing countries. Infections caused by this bacterium generate a high cost on health care systems. Traditionally, the management of this infection is given through therapy with antimicrobials such as metronidazole and vancomycin. However, with the increase in resistance to antibiotics and the emergence of hypervirulent and epidemic strains such as NAP1/027, the search for other therapeutic options is essential. The objective of this review is to study the first-line treatment that has been used for this bacterium, as well as to learn about new antibiotic molecules and active and passive immunization strategies that have emerged in recent years as alternative treatments, some of which are still are under investigation.

Keywords: Clostridioides difficile; Ridinilazole; Raja 42; Bezlotoxumab; Vaccines


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Citation: Gian Carlo González-Carballo. “Antibiotic and Immunological Alternatives for the Management of Clostridioides difficile Infection".Acta Scientific Microbiology 7.1 (2024): 77-81.


Copyright: © 2024 Gian Carlo González-Carballo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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