Priyanka Chaturvedi¹, Rimjhim, Pathak², Subhash Chandra Biyan³, Himani Parihar¹ and Prem Saran Tirumalai¹*

¹Dayalbagh Educational Institute, Faculty of Science, Department of Agriculture Sciences, Uttar Pradesh, India

*Corresponding Author: Prem Saran Tirumalai, Dayalbagh Educational Institute, Faculty of Science, Department of Agriculture Sciences, Uttar Pradesh, India.

Received: August 17, 2023; Published: September 19, 2023

Abstract

Colorectal cancer is a major global health concern, with a strong link to processed meat consumption and the formation of carcinogenic compounds. This study explores the potential of selected probiotic strains, including Lactobacillus plantarum, Lactobacillus casei, and Bifidobacterium bifidum, in degrading a specific carcinogen called 4-Nitroquinoline-1-Oxide (4-NQO). The research investigates the effect of 4-NQO on the growth of the test organisms individually and as a consortium, as well as the degradation of 4-NQO by the test organisms. The study employs culture methods and High-Performance Liquid Chromatography (HPLC) to analyze the growth patterns and degradation of 4-NQO over specific time intervals. The results show minimal impact of 4-NQO on the growth of Lactobacillus casei, while Lactobacillus plantarum demonstrates a slight decline in growth. Bifidobacterium bifidum exhibits consistent growth patterns in the presence of 4-NQO, indicating resilience to the carcinogen. Additionally, the consortium of cultures shows similar trends to the individual strains. These findings also contribute to understanding the potential role of selected probiotic species in the degradation of 4-NQO and its implications for cancer mitigation.

 Keywords: 4-Nitroquinoline-1-Oxide (4-NQO); Lactobacillus casei; Lactobacillus plantarum; Bifidobacterium bifidum

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Citation

Citation: Prem Saran Tirumalai., et al. “Degradation of 4-Nitroquinoline-1-Oxide by Lactic Acid Bacteria". Acta Scientific Microbiology 6.10 (2023): 22-30.

Copyright

Copyright: © 2023 Prem Saran Tirumalai., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.