Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 6 Issue 9

Humoral and Cellular Immune Response in Kidney Transplant Recipients with COVID-19 Vaccination: A Systematic Review and Meta-Analysis

Ruangrong Cheepsattayakorn1, Attapon Cheepsattayakorn2,3* and Porntep Siriwanarangsun2

1Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

2Faculty of Medicine, Western University, Pathum Thani Province, Thailand

310th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: July 28, 2023; Published: August 14, 2023


A comprehensive search was carried out in mainstream bibliographic databases or Medical Subject Headings, including ScienDirect, PubMed, Scopus, and ISI Web of Science. The search was applied to the articles that were published between 2021 and mid-2023. With strict literature search and screening processes, it yielded 7 articles from 349 articles of initial literature database. A number of previous studies demonstrated that KTRs or non-KTRs with renal failure markedly reduced vaccine response, whereas adaptive protocols of mRNA COVID-19 vaccination or alternative adjuvant vaccines is now not known yet. A recent study revealed that acute kidney injury and mortality could be caused by SARS-CoV-2 (COVID-19) around 50% and 23% of the infected KTRs.

In conclusion, among the immunocompromised population, including KTRs, DPs, PDs, at least three doses of mRNA-COVID-19 vaccination was recommended to be the preparation of choice. Withdrawal of the immunosuppressants in KTRs and immunocompromised individuals prior COVID-19 vaccination and at least third dose of mRNA-COVID-19 vaccination should be performed.

 Keywords: Cellular; Humoral; Immune; Response; Kidney; Transplant; Hemodialysis; COVID-19; Vaccine; mRNA


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Citation: Attapon Cheepsattayakorn., et al. “Humoral and Cellular Immune Response in Kidney Transplant Recipients with COVID-19 Vaccination: A Systematic Review and Meta-Analysis". Acta Scientific Microbiology 6.9 (2023): 60-65.


Copyright: © 2023 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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