V Vahita¹*, Growther Lail², SM Jobair Hossain³ and S Kadar Basha⁴

¹PhD Student, Department of Microbiology, Hindusthan College of Arts and Science, Tamil Nadu, India

*Corresponding Author: V Vahita, PhD Student, Department of Microbiology, Hindusthan College of Arts and Science, Tamil Nadu, India.

Received: July 12, 2023; Published: August 09, 2023

Abstract

The significance of natural flora is well known by the scientific community. The medicinal plant gifted by nature have been explored by the humans to find out their respective values in the medical field. Nigella sativa has been used as traditional medicine for centuries. The aim of this study is that to test the phytochemical screening and antioxidant capabilities of methanolic extract of Nigella sativa seeds. In the present study the seeds were powdered and the best methanol extracts were screened for Preliminary phytochemical investigations. Seed powder showed the presence of alkaloids, flavonoids, saponins, carbohydrates, tannins, sterols, glycosides, phenolic compounds, protein and amino acids and absence of gums, mucilage, oil and fats. The experimental data indicated that Nigella sativa seeds displayed the highest DPPH scavenging effect (82%) with the help of standard graph plotted using standard antioxidant compound. Finally, the results obtained in this study that Nigella sativa possess significant amount of antioxidants and phytochemical compounds.

 Keywords: Nigella sativa; Phytochemistry

References

1. Criagg GM and JN David. “Natural product drug discovery in the next millennium”. Journal of Pharmaceutical and Biological Sciences 39 (2001): 8-17 .
2. Merfort I., et al. “Flavonoltriglycosides from seeds of Nigella sativa”. Phytochemistry 46 (1997): 359-363.
3. Khan MA. “Chemical composition and medicinal properties of Nigella sativa Linn”. Inflammopharmacology 1 (1999): 15-35.

4.       Elvy Suhana Mohd Ramli., et al. “Nigella sativa: A Potential Antiosteoporotic Agent”. Evidence-Based Complementary and Alternative Medicine Volume (2012): 6.

5. Alenzi FQ., et al. “Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide”. British Journal of Biomedical Science 67 (2010): 20-28. 
6. Phillips JD. “Medicinal plants”. Biologist 39 (1992): 187-191.
7. Boseila AA and Messalam AA. “Immunostimulant effect of different fractions of Nigella sativa L. seeds against Rabies vaccine”. Nature Science2 (2011): 7.
8. Ahmad Nazrun Shuid., et al. “Nigella sativa: A Potential Antiosteoporotic Agent”. Evidence-Based Complementary and Alternative Medicine (2012): 6.
9. Gilani AH., et al. “Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses”. Journal of Pakistan Medical Association 3 (2001): 115-120.
10. Randhawa MA and Alghamdi MS. “Anticancer activity of Nigella sativa (black seed)—a review”. The American Journal of Chinese Medicine6 (2021): 1075-1091.
11. Sheik Noor Mohamed M., et al. “A study on the in vitro antifungal activity of nigella sativa (linn.) seed extract and it's phytochemical screening using gc-ms analysis”. World Journal of Pharmacy and Pharmaceutical Sciences8 (2015): 1003-1011.
12. Mahmoud YK and Abdelrazek HM. “Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy”. Biomedicine and Pharmacotherapy115 (2019): 108783.
13. Boskabady MH., et al. “Antiasthmatic effect of Nigella sativa in airways of asthmatic patients”. Phytomedicine (2010).
14. Farah IO and Begum RA. “Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells”. Biomedical Sciences Instrumentation 39 (2003): 359-364.

Citation

Citation: V Vahita., et al. “Black Cumin (Nigella sativa L.): Studies on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety". Acta Scientific Microbiology 6.9 (2023): 38-44.

Copyright

Copyright: © 2023 V Vahita., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.