Gastrointestinal Microbiota Dysbiosis and Crohn’s Disease

Infectious Diseases Incorporated - University of Florida College of Veterinary Medicine, Florida

*Corresponding Author: Gilles RG Monif, Infectious Diseases Incorporated - University of Florida College of Veterinary Medicine, Florida.

Received: June 27, 2023; Published: July 12, 2023

Abstract

The broad label of dysbiosis has been advanced as a catch all for a growing number of medical conditions in which reorganization of the gastrointestinal microbiota have been documented. That significant differences exist between the gastrointestinal microbiota of individuals with Crohn’s disease and non-afflicted individuals put into question a possible role in disease causation. The paper presents the argument that inflammatory induced changes within the microbiological environment is responsive for the deregulation of interbacterial dominance and that the “dysbiosis “of Crohn’s disease is a cause and not an effect.

 Keywords: Dysbiosis; Crohn’s Disease; Pathogenesis

References

1. Oka A and Sartor RB. “Microbial-based and microbial-targeted therapies for inflammatory bowel diseases”. Digestive Diseases and Sciences 65 (2020): 757-788.
2. Gevers D., et al. “The treatment-naïve microbiome in new onset Crohn’s disease”. Cell Host Microbe 15 (2014): 382-392.
3. Khanna S and Raffals LE. “The microbiome in Crohn’s disease: Role on pathogenesis and role of microbiome replacement therapies”. Gastroenterology Clinics of North America 46 (2017): 481-492.
4. Frank DN., et al. “Molecular phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases”. Proceedings of the National Academy of Sciences of the United States of America 104 (2007): 13780-13785.
5. Magro DO., et al. “Remissions in Crohn’s disease is accompanied by alterations in the gut microbiota and mucins production”. Scientific Report 9 (2019): 13263.
6. Walters SS., et al. “Analysis of gut microbiome and diet modification in patients with Crohn’s disease”. SOJ Microbiology and Infectious Diseases 2 (2014): 1-13.
7. Joossens M., et al. “Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives”. Gut 60 (2011): 631-637.
8. Brusaferro A., et al. “Gut dysbiosis and paediatric Crohn’s disease”. Journal of Infectious 78 (2019): 1-7.
9. Øyri SF., et al. “Dysbiotic gut microbiome: A key element of Crohn’s disease”. Comparative Immunology, Microbiology and Infectious Diseases 43 (2015): 36-49.
10. Carrière J., et al. “Infectious enteropathogenesis of Crohn’s disease”. Journal of Gastroenterology20 (2014): 12102-12107.
11. ‘Schaubeck M., et al. “Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence”. Gut 65 (2016): 225-237.
12. Khanna S and Raffals LE. “The microbiome in Crohn’s Disease: Role in pathogenesis and role of microbiome replacement therapies”. Gastroenterology Clinics of North America 46 (2017): 481-492.
13. Shiga H., et al. “Changes of fecal microbiota in patients with Crohn’s disease treated with an elemental diet and total parenteral nutrition”. Digestive and Liver Disease 44 (2012): 736-742.
14. Monif GRG. “Hruska postulate”. Medical Hypothesis 85 (2015): 878-881.
15. Monif GRG. “An infectious disease process within an immune-mediated disease process: Role of the gastrointestinal microbiota in Crohn’s disease”. Advanced Research in Gastroenterology and Hepatology5 (2017): 1-2.
16. Monif GRG. “Crohn’s disease; the infectious Disease Incorporated’s perspective”. Gastrointestinal Disorder 3 (2021): 138-141.
17. Chow J and Mazmanian SK. “A pathobiont of the microbiota balances colonization and intestinal inflammation”. Cell Host Microbe 7 (2010): 265-276.
18. Larsen B and Monif GRG. “Understanding the bacterial flora of the female genital tract”. Clinical Infectious Diseases 32 (2003): 69e-77e.
19. Carson HJ., et al. “Interrelationships within the bacterial flora of the female genital tract”. Infectious Diseases in Obstetrics and Gynecology 5 (1997): 305-309.
20. Pongsakdi C., et al. “In vitro ability of the group B streptococci to inhibit gram-positive and gram-variable constituents of the female genital tract bacterial flora”. Infectious Diseases in Obstetrics and Gynecology (1995): 391-397.
21. Monif GRG. “Semi-quantitative bacterial observations with group B vaginitis”. Infectious Diseases in Obstetrics and Gynecology 7 (1999): 227-229.
22. Monif G RG., et al. “Quantitative and qualitative effects of betadine liquid on the aerobic and anaerobic flora of the female genital tract”. American Journal of Obstetrics and Gynecology 137 (1980): 432438.
23. Brussow H. “Problems with the concept of gut microbiota dysbiosis”. Microbial Biotechnology 13 (2019): 423-434.

Citation

Citation: Gilles RG Monif. “Gastrointestinal Microbiota Dysbiosis and Crohn’s Disease". Acta Scientific Microbiology 6.8 (2023): 15-18.

Copyright

Copyright: © 2023 Gilles RG Monif. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.