The Role of Microbiome on Neurodegenerative Diseases
Medical Biotechnology, Dr. DY. Patil University, India
*Corresponding Author: Palak Bafna, Medical Biotechnology, Dr. DY. Patil University, India.
May 25, 2023; Published: June 20, 2023
Neurodegenerative diseases (NDDs) are a heterogeneous group of neurological disorders adversely affecting the lives of millions of people worldwide and entail the progressive loss of neurons in the central nervous system (CNS) or peripheral nervous system (PNS). They present a unique challenge in the modern research landscape. Despite decades of research, our understanding of the underlying causes and mechanisms still needs to be improved, and very few effective treatments exist. Given the lack of progress, the research community's attention has recently shifted toward other mediators of neurological disease that may present future targets for therapeutic research. One such mediator is the gut microbiome, which communicates with the brain through the gut-brain axis and has been implicated in various neurological disorders.
The gut-brain axis, encompasses the bidirectional interaction between the gut and brain through neural, immune, endocrine, and metabolic channels.
Keywords: Neurodegenerative Diseases (NDDs); Central Nervous System (CNS); Peripheral Nervous System (PNS)
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