Oladipo IC*, Ajadi KA and Ogunsona SB

Department of Science Laboratory Technology, Ladoke Akintola University of Technology, Oyo State, Nigeria

*Corresponding Author: Oladipo IC, Professor, Department of Science Laboratory Technology, Ladoke Akintola University of Technology, Oyo State, Nigeria.

Received: May 18, 2023; Published: June 20, 2023

Abstract

Nanotechnology is one of the leading innovations in this dispensation; this research describes the green synthesis of gold nanoparticles from Icacina trichantha, and some of its biomedical applications. The extract of Icacina trichantha served as the reducing/capping agents while the gold chloride solution served as the precursor, the reaction resulted in colloidal suspension formation after photo-activation. The colloidal suspension was characterized using UV-Vis spectroscopy, FTIR, EDX and SEM. The UV-Vis spectrum of the AuNPs displayed strong peak at 562 nm. The FTIR showed prominent peaks at 3425.69, 2928.04, 2362.88, 1763.00, 1635.69, 1384.94 and 1089.82 cm^-1, these are attributed to the involvement of proteins in the AuNPs bio-fabrication and capping. Gold was the most occurring metal noted in the EDX analysis while the SEM micrograph of the nanoparticles showed sizes between 23.34 – 79.69nm.

The AuNPs showed antifungal activity of 64.1%, 75.9%, 70.6%, 72.6% and 77.1% against Fusarium solani, Fusarium poae, Aspergillus niger, Aspergillus flavus and Penicillium avenatum respectively at 150 µl /ml. The AuNPs showed significant antioxidant properties of 78.11%, 79.43% and 81.56% at 50, 100, 150 and 200µl/ml against DPPH. The AuNPs showed a significant decrease in angiotensin converting enzyme (ACE) inhibitory activities as the concentration increased. The AuNPs showed angiotensin converting enzyme inhibitory activities of 44.94 ± 1.094, 40.14 ± 0.3604, 37.25 ± 0.06860 and 36.76 ± 0.03091% at concentration 50, 100, 150 and 200 µg/ml respectively. Conclusively, the AuNPs could be applied in fumigants production, and formulation of agents against oxidative stress. The nanoparticles also displayed anti-hypertensive activities and could be used as a therapeutic agent in the control of blood pressure.

 Keywords: Gold Nanoparticles; Antioxidant; Antifungal; Anti-Hypertensive

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Citation

Citation: Oladipo IC., et al. “In-vitro Anti-hypertensive, Anti-oxidant and Anti-fungal Properties of Green Synthesized Gold Nanoparticles from Icacina Trichantha Leaf Aqueous Extract". Acta Scientific Microbiology 6.7 (2023): 27-34.

Copyright

Copyright: © 2023 Oladipo IC., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.