Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 6 Issue 6

Molecular Docking - Study of Potential Cyclophilin-Dependent Mechanism of SARS-CoV-2 Viral Entry

Aneta Maria Molenda*

Department of Molecular Genetics, UK

*Corresponding Author: Aneta Maria Molenda, Department of Molecular Genetics, UK.

Received: April 27, 2023; Published: May 30, 2023

Abstract

Objectives: The aim of this article is to analyse interaction of the SARS-CoV2 fragments with cyclophilins and to validate the mechanism of the viral entry involving spike glycoprotein or membrane proteins.

Coronavirus Disease: COVID-19 is a disease caused by RNA virus that got potential to cause respiratory and intestinal illness in humans as well as animals. There are 7 different type of Coronavirus diseases (229E, NL63, OC43, HKU1, MERS-CoV, SARS-CoV, SARS-CoV-2) reported in humans that are known to cause illness ranging from common cold to more severe forms [1]. The epicentre of the COVID-19 disease was Wuhan city, Huban province of China where a cluster of unexplained pneumonia cases of unknown aetiology were officially reported on Dec 31 2019 [2]. Though Covid-19 has a lower mortality rate (2.3%) than SARS (9.5%) or MERS (34.4%) it is highly transmissible and has rapidly progressed from epidemic to pandemic scale [3].

 Keywords: SARS-CoV-2; Covid-19; Docking

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    Citation

    Citation: Aneta Maria Molenda. “Molecular Docking - Study of Potential Cyclophilin-Dependent Mechanism of SARS-CoV-2 Viral Entry". Acta Scientific Microbiology 6.6 (2023): 81-101.

    Copyright

    Copyright: © 2023 Aneta Maria Molenda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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