Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1
1Faculty of Medicine, Western University, Pathumtani Province, Thailand 210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand 3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.
Received: April 24, 2023; Published: April 27, 2023
For better understanding SARS-CoV-2-infection pathophysiology for preclinical development of countermeasure, hamster model is widely used [1], whereas, diffuse pulmonary alveolar damage is frequently found in hospitalized COVID-19 patients [2-4]. Evaluation of animal models of Middle East respiratory syndrome coronavirus (MERS-CoV) have been previously used by positron emission tomography with computed tomography (CT), CT, (PET/CT), and single-photon emission computerized tomography (SPECT) [5]. In addition to being able to nasal-turbinate-damage determination, differentiation of COVID-19-lung-disease severity from mild to severe degrees was successful (Figure 1) [1]. Direct correlation between site-inflammatory-metabolic-cell activity and 18F-Fluorodeoxyglucose (FDG) uptake was demonstrated [1].
Citation: Attapon Cheepsattayakorn., et al. “Measurement of COVID-19 Severity in Humanized Animal Model by 18F-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography". Acta Scientific Microbiology 6.6 (2023): 01-04.
Copyright: © 2022 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.