Acta Scientific Microbiology (ISSN: 2581-3226)

Editorial Volume 6 Issue 6

Measurement of COVID-19 Severity in Humanized Animal Model by 18F-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography

Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1

1Faculty of Medicine, Western University, Pathumtani Province, Thailand

210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand

3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: April 24, 2023; Published: April 27, 2023

For better understanding SARS-CoV-2-infection pathophysiology for preclinical development of countermeasure, hamster model is widely used [1], whereas, diffuse pulmonary alveolar damage is frequently found in hospitalized COVID-19 patients [2-4]. Evaluation of animal models of Middle East respiratory syndrome coronavirus (MERS-CoV) have been previously used by positron emission tomography with computed tomography (CT), CT, (PET/CT), and single-photon emission computerized tomography (SPECT) [5]. In addition to being able to nasal-turbinate-damage determination, differentiation of COVID-19-lung-disease severity from mild to severe degrees was successful (Figure 1) [1]. Direct correlation between site-inflammatory-metabolic-cell activity and 18F-Fluorodeoxyglucose (FDG) uptake was demonstrated [1].

References

  1. Cong Y., et al. “Longitudinal analyses using 18F-Fluorodeoxyglucose positron emission tomography with computed tomography as a measure of COVID-19 severity in the aged, young, and humanized ACE2 SARS-CoV-2 hamster models”. Antiviral Research AVR 105605 (2023): PII: S0166-3542)23)00083-9.
  2. Barton LM., et al. “COVID-19 autopsies, Oklahoma, USA”. American Journal of Clinical Pathology 153 (2020): 725-733.
  3. Borczuk AC., et al. “COVID-19 pulmonary pathology : a multi-institutional autopsy cohort from Italy and New York City”. Modern Pathology 33 (2020): 2156-2168.
  4. D’Agnillo F., et al. “Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19”. Science Translational Medicine 13 (2021): eabj7790.
  5. Chefer S., et al. “The human sodium iodide symporter as a reporter gene for studying Middle-East-Respiratory-Syndrome coronavirus pathogenesis”. mShere 3 (2018): e00540-00518.

Citation

Citation: Attapon Cheepsattayakorn., et al. “Measurement of COVID-19 Severity in Humanized Animal Model by 18F-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography". Acta Scientific Microbiology 6.6 (2023): 01-04.

Copyright

Copyright: © 2022 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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