Attapon Cheepsattayakorn^1,2*, Ruangrong Cheepsattayakorn³ and Porntep Siriwanarangsun¹

¹Faculty of Medicine, Western University, Pathumtani Province, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10^th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: April 24, 2023; Published: April 27, 2023

For better understanding SARS-CoV-2-infection pathophysiology for preclinical development of countermeasure, hamster model is widely used [1], whereas, diffuse pulmonary alveolar damage is frequently found in hospitalized COVID-19 patients [2-4]. Evaluation of animal models of Middle East respiratory syndrome coronavirus (MERS-CoV) have been previously used by positron emission tomography with computed tomography (CT), CT, (PET/CT), and single-photon emission computerized tomography (SPECT) [5]. In addition to being able to nasal-turbinate-damage determination, differentiation of COVID-19-lung-disease severity from mild to severe degrees was successful (Figure 1) [1]. Direct correlation between site-inflammatory-metabolic-cell activity and ¹⁸F-Fluorodeoxyglucose (FDG) uptake was demonstrated [1].

References

1. Cong Y., et al. “Longitudinal analyses using 18F-Fluorodeoxyglucose positron emission tomography with computed tomography as a measure of COVID-19 severity in the aged, young, and humanized ACE2 SARS-CoV-2 hamster models”. Antiviral Research AVR 105605 (2023): PII: S0166-3542)23)00083-9.
2. Barton LM., et al. “COVID-19 autopsies, Oklahoma, USA”. American Journal of Clinical Pathology 153 (2020): 725-733.
3. Borczuk AC., et al. “COVID-19 pulmonary pathology : a multi-institutional autopsy cohort from Italy and New York City”. Modern Pathology 33 (2020): 2156-2168.
4. D’Agnillo F., et al. “Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19”. Science Translational Medicine 13 (2021): eabj7790.
5. Chefer S., et al. “The human sodium iodide symporter as a reporter gene for studying Middle-East-Respiratory-Syndrome coronavirus pathogenesis”. mShere 3 (2018): e00540-00518.

Citation

Citation: Attapon Cheepsattayakorn., et al. “Measurement of COVID-19 Severity in Humanized Animal Model by ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography". Acta Scientific Microbiology 6.6 (2023): 01-04.

Copyright

Copyright: © 2022 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.