Acta Scientific Microbiology (ISSN: 2581-3226)

Mini Review Volume 6 Issue 5

Adenovirus an Increasing Concern in West Bengal - Manifestation, Detection, Prevention and Treatment

Bijurica Chakraborty1, Sounik Sarkar1, Anowara Gazi1, Santanu Das1, Md Selim Jafor1 and Rajib De1,2*

1Multi-disciplinary Research Unit (MRU), Nil Ratan Sircar Medical College and Hospital, Kolkata, India

2Department of Haematology, Nil Ratan Sircar Medical College and Hospital, Kolkata, India

*Corresponding Author: Rajib De, Multi-disciplinary Research Unit (MRU), Nil Ratan Sircar Medical College and Hospital, Kolkata, India.

Received: April 10, 2023; Published: April 20, 2023


Human Adenovirus (hAdv) infections are currently at a surge in India with West Bengal holding a prominent place. Patient cohort with majority being children are getting reported with flue like symptoms, low oxygen level and upper respiratory tract infection. Diarrhoea and pink eyes are also getting noted. Clinical manifestations by different serotypes of the aforementioned DNA virus were previously confined to multifaceted mild symptoms but recently taking a serious toll mainly due to mutant varieties of the virus. Since contamination spreads mainly through droplet infection and faecal-oral route, personal hygiene holds most superior preventive measure. Patient infective swabs, stool and/or blood can be tested for presence of hAdv by different diagnostic methods, PCR based techniques being commonly followed in most pathological laboratories. Number of patients both paediatric and adults are getting admitted in different hospitals of West Bengal with increasing reports of hAdv infection. Treatments for specific clinical symptoms are provided to admitted cases, whereas certain drugs like Ganciclovir and Ribavirin are used to treat severe hAdv infections, but with variable success rate. Drug Cidofovir had shown some degree of moderate success in treatment of immune-compromised hAdv patients. However, no specific treatment has been reported till date for hAdv infection.

Keywords: Adenovirus; hAdv; Infection; Diagnosis; Reported Cases; West Bengal


  1. Lenaerts L and Naesens L. “Antiviral therapy for adenovirus infections”. Antiviral Research2-3 (2006): 172-180.
  2. Guner A., et al. “Molecular analysis of human adenoviral keratoconjunctivitis cases: Results of a 2-year survey”. Marmara Medical Journal1 (2023): 1-6.
  3. Dey RS., et al. “Circulation of a novel pattern of infections by enteric adenovirus serotype 41 among children below 5 years of age in Kolkata, India”. Journal of Clinical Microbiology2 (2011): 500-505.
  4. Kunz AN and Ottolini M. “The role of adenovirus in respiratory tract infections”. Current Infectious Disease Reports 2 (2010): 81-87.
  5. Lynch JP., et al. “Adenovirus”. Seminars in Respiratory and Critical Care Medicine4 (2011): 494-511.
  6. Khanal S., et al. “The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly”. Biomedicines1 (2018): 30.
  7. Mukherjee D., et al. “Acute hepatitis with unknown etiology amidst the COVID-19 and monkeypox time: an emerging global concern among the children”. International Journal of Surgery2 (2023): 126-128.
  8. Martin NA., et al. “Adeno-Associated Virus 2 and Human Adenovirus F41 in Wastewater during Outbreak of Severe Acute Hepatitis in Children, Ireland”. Emergency Infectious Disease4 (2023): 751-760.
  9. Al-Siyabi T., et al. “A cost effective real-time PCR for the detection of adenovirus from viral swabs”. Virology Journal 10 (2013): 184.
  11. Akhil C., et al. “Genotyping of human adenoviruses circulating in Southwest India”. Virus Disease 3 (2016): 266-270.
  12. Barr RS and Drysdale SB. “Viral Respiratory Tract Infections in the Immunocompromised Child”. The Pediatric Infectious Disease Journal (2023).
  13. Dey RS., et al. “Circulation of a novel pattern of infections by enteric adenovirus serotype 41 among children below 5 years of age in Kolkata, India”. Journal of Clinical Microbiology2 (2011): 500-505.
  14. Lynch JP and Kajon AE. “Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention”. Seminars in Respiratory and Critical Care Medicine4 (2016): 586-602.
  15. Pehler-Harrington K., et al. “Rapid detection and identification of human adenovirus species by adenoplex, a multiplex PCR-enzyme hybridization assay”. Journal of Clinical Microbiology9 (2004): 4072-4076.
  17. Datta N. “A review of molecular biology detection methods for human adenovirus”. AIMS Biophysics1 (2023): 95-120.
  18. Ho A., et al. “Adeno-associated virus 2 infection in children with non-A-E hepatitis”. Nature (2023).
  19. Sarantis H., et al. “Comprehensive detection and serotyping of human adenoviruses by PCR and sequencing”. Journal of Clinical Microbiology9 (2004): 3963-3969.
  27. Samudrala PK., et al. “Virology, pathogenesis, diagnosis and in-line treatment of COVID-19”. European Journal of Pharmacology 883 (2020): 173375.
  28. Cosar B., et al. “SARS-CoV-2 Mutations and their Viral Variants”. Cytokine Growth Factor Review 63 (2022): 10-22.
  29. Li Y., et al. “Human adenovirus type 7 virus-like particle vaccine induces Dendritic cell maturation through the TLR4/NF-κB pathway and is highly immunogenic”. Antiviral Research 212 (2023): 105559.
  34. Carducci A., et al. “Quantitative Microbial Risk Assessment in Occupational Settings Applied to the Airborne Human Adenovirus Infection”. International Journal of Environmental Research and Public Health7 (2016): 733.
  35. Kojaoghlanian T., et al. “The impact of adenovirus infection on the immunocompromised host”. Reviews in Medical Virology 3 (2003): 155-171.
  36. McNeil MM., et al. “Adverse events following adenovirus type 4 and type 7 vaccine, live, oral in the Vaccine Adverse Event Reporting System (VAERS), United States, October 2011-July 2018”. Vaccine 44 (2019): 6760-6767.


Citation: Rajib De., et al. “Adenovirus an Increasing Concern in West Bengal - Manifestation, Detection, Prevention and Treatment". Acta Scientific Microbiology 6.5 (2023): 74-78.


Copyright: © 2023 Rajib De., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is May 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US