Acta Scientific Microbiology (ISSN: 2581-3226)

Review Article Volume 6 Issue 3

A Short Review of Gold-Alkane Thiolate Nanoclusters: Functionalizations, Properties, and Biomedical Applications

Tatenda Justice Gunda1*, Bachir Yaou Balarabe1 and Irédon Adjama2

1School of Engineering and Technology, National Forensic Sciences University, India

2School of Pharmacy, National Forensic Sciences University, India

*Corresponding Author: Tatenda Justice Gunda, School of Engineering and Technology, National Forensic Sciences University, India.

Received: January 05, 2023; Published: February 10, 2023

Abstract

A brand-new class of nanoclusters based on thiolates is emerging with fascinating properties as well as behavior (e.g. dispersibility, surface functionalization, color, etc.). Such nanoclusters can be defined as small nanoparticles with properties similar to those of molecules, and thus can be considered to bridge the gap between the nanoparticle and the atom by combining their properties. There are a number of applications where thiols can be used as protective ligands for the stabilization and functionalization of metal nanoparticles, such as silver and gold. Nanoclusters (NCs) have a core-shell structure where the core is made up of a few Metal Oxide (MO) atoms, but it's surrounded by M-thiolate molecules that form a shell(s) around the core in order to prevent particle aggregation. Therefore, thiolate molecules serve as capping agents on particle surfaces to prevent particle aggregation. As well as being used for drug delivery, alkane thiolate NCs can also be used for photobacterial activity, photodynamic therapy delivery of DNA plasmids into target cells, as well as for increasing magnetic resonance imaging through photodynamic therapy. It has also been found that gold nanoparticles can penetrate cells and are not toxic in any way whatsoever. In this paper, we discuss the use of alkane thiolate nanocluster functionalized-gold nanoparticles in biomedicine due to their excellent biocompatibility and attractive chemical and physical properties.

Keywords: Alkane Thiolate; Nanocluster; Functionalization; Toxicity; Imaging; Photobacterial; Antimicrobial; Cytotoxicity

References

  1. X Huang., et al. “Nanotechnology-Enhanced No-Wash Biosensors for in Vitro Diagnostics of Cancer”. ACS Nano 11 (2017): 5238-5292.
  2. MJ Hostetler., et al. “Infrared spectroscopy of three-dimensional self-assembled monolayers: N-alkanethiolate monolayers on gold cluster compounds”. Langmuir 12 (1996): 3604-3612.
  3. RJ Fealy., et al. “Mechanism of spontaneous formation of monolayers on gold from alkyl thiosulfates”. Langmuir 27 (2011): 5371-5376.
  4. T Udayabhaskararao., et al. “Thiolate-protected Ag32 clusters: Mass spectral studies of composition and insights into the Ag-thiolate structure from NMR”. Nanoscale 5 (2013): 9404-9411.
  5. A Desireddy., et al. “Ultrastable silver nanoparticles”. Nature 501 (2013): 399-402.
  6. M Brack. “The physics of simple metal clusters: Self-consistent jellium model and semiclassical approaches”. Reviews of Modern Physics 65 (1993): 677-732.
  7. DA MC Daniel. “Gold nanoparticles: assembly, supramolecularchemistry, quantum-size-related properties, and applications toward”. Chemical Review 104 (2004): 293-346.
  8. TL Doane and C Burda. “The unique role of nanoparticles in nanomedicine: Imaging, drug delivery and therapy”. Chemical Society Reviews 41 (2012): 2885-2911.
  9. B Adhikari and A Banerjee. “Facile synthesis of water-soluble fluorescent silver nanoclusters and HgII sensing”. Chemistry of Materials 22 (2010): 4364-4371.
  10. I Russier-Antoine., et al. “Tuning Ag29 nanocluster light emission from red to blue with one and two-photon excitation”. Nanoscale 8 (2016): 2892-2898.
  11. N Goswami., et al. “Functionalization and Application”. Elsevier, (2015).
  12. R Jin., et al. “All-thiolate-protected silver and silver-rich alloy nanoclusters with atomic precision: stable sizes, structural characterization and optical properties”. CrystEngComm 18 (2016): 3996-4005.
  13. AS Nair., et al. “Nanoparticles-chemistry, new synthetic approaches, gas phase clustering and novel applications”. Pramana 65 (2005): 631-640.
  14. L Suber., et al. “Nanocluster superstructures or nanoparticles? the self-consuming scaffold decides”. Nanoscale 10 (2018): 7472-7483.
  15. PD Jadzinsky., et al. “Structure of a thiol monolayer-protected gold nanoparticle at 1.1 Å resolution”. Science (80-. ). 318 (2007): 430-433.
  16. X Yuan., et al. “Ultrasmall Ag+-rich nanoclusters as highly efficient nanoreservoirs for bacterial killing”. Nano Research 7 (2014): 301-307.
  17. SM Copp., et al. “Heterogeneous Solvatochromism of Fluorescent DNA-Stabilized Silver Clusters Precludes Use of Simple Onsager-Based Stokes Shift Models”. The Journal of Physical Chemistry Letters 7 (2016): 698-703.
  18. MS Kim., et al. “Ag16 (SG)9 nanoclusters as a light harvester for metal-cluster-sensitized solar cells”. Bulletin of the Korean Chemical Society 37 (2016): 791-792.
  19. L Zhang., et al. “Nanotechnology in therapeutics : a focus on nanoparticles as a drug delivery system R eview”. Carbohydrate Polymers 1 (2016): 71-88.
  20. I Dolamic., et al. “First enantioseparation and circular dichroism spectra of Au38 clusters protected by achiral ligands”. Nature Communication 3 (2012): 1-6.
  21. S Wang., et al. “A 200-fold quantum yield boost in the photoluminescence of silver-doped AgxAu25-x nanoclusters: The 13 th silver atom matters”. Angewandte Chemie - Int. Ed. 53 (2014): 2376-2380.
  22. I Chakraborty and T Pradeep. “Atomically Precise Clusters of Noble Metals: Emerging Link between Atoms and Nanoparticles”. Chemical Review 117 (2017): 8208-8271.
  23. T Higaki., et al. “Toward the Tailoring Chemistry of Metal Nanoclusters for Enhancing Functionalities”. Accounts of Chemical Research 51 (2018): 2764-2773.
  24. Z Tang., et al. “Oxygen reduction reaction catalyzed by noble metal clusters”. Catalysts 8 (2018).
  25. J Yan., et al. “Surface Chemistry of Atomically Precise Coinage-Metal Nanoclusters: From Structural Control to Surface Reactivity and Catalysis”. Accounts of Chemical Research 51 (2018): 3084-3093.
  26. XR Song., et al. “Functionalization of metal nanoclusters for biomedical applications”. Analyst 141 (2016): 3126-3140.
  27. H Gu., et al. “Biofunctional magnetic nanoparticles for protein separation and pathogen detection”. ChemComm (2006): 941-949.
  28. H Häkkinen. “The gold-sulfur interface at the nanoscale”. Nature Chemistry 4 (2012): 443-455.
  29. Z Zhang and PC Lin. “Noble metal nanoparticles: Synthesis, and biomedical implementations”. Elsevier Inc., (2018).
  30. YK Mohanta., et al. “Bacterial synthesized metal and metal salt nanoparticles in biomedical applications: An up and coming approach”. Applied Organometallic Chemistry 34 (2020): 1-19.
  31. RW Murray. “ChemInform Abstract: Nanoelectrochemistry: Metal Nanoparticles, Nanoelectrodes, and Nanopores”. ChemInform 39 (2008): 2688-2720.
  32. H Gu., et al. “Using biofunctional magnetic nanoparticles to capture Gram-negative bacteria at an ultra-low concentration”. ChemCommun 3 (2003): 1758-1759.
  33. Y Wang., et al. “Nucleation and island growth of alkanethiolate ligand domains on gold nanoparticles”. ACS Nano 6 (2012): 629-640.
  34. Y Zheng., et al. “Wang, Recent advances in biomedical applications of fluorescent gold nanoclusters”. Elsevier B.V, (2017).
  35. YZ Lu., et al. “Copper nanoclusters: Synthesis, characterization and properties”. Chinese Science Bulletin 57 (2012): 41-47.
  36. A Biswas., et al. “Gold Nanocluster Containing Polymeric Microcapsules for Intracellular Ratiometric Fluorescence Biosensing”. ACS Omega 2 (2017): 2499-2506.
  37. T Wang., et al. “Near-Infrared Electrogenerated Chemiluminescence from Aqueous Soluble Lipoic Acid Au Nanoclusters”. Journal of the American Chemical Society 138 (2016): 6380-6383.
  38. JD Gibson., et al. “Paclitaxel-Functionalized Gold Nanoparticles”. (2007): 11653-11661.
  39. AC Templeton., et al. Ar9602664.Pdf, 33 (2000): 27-36.
  40. B Duncan., et al. “Gold nanoparticle platforms as drug and biomacromolecule delivery systems”. Journal of Controlled Release 148 (2010): 122-127.
  41. S GuhaSarkar and R Banerjee. “Intravesical drug delivery: Challenges, current status, opportunities and novel strategies”. Journal of Controlled Release 148 (2010): 147-159.
  42. CC Hsu., et al. “Intravesical drug delivery for dysfunctional bladder”. International Journal of Urology 20 (2013): 552-562.
  43. A Štorha., et al. “Synthesis of thiolated and acrylated nanoparticles using thiol-ene click chemistry: Towards novel mucoadhesive materials for drug delivery”. RSC Advances 3 (2013): 12275-12279.
  44. J Barthelmes., et al. “Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder”. International Journal of Pharmaceutics 416 (2011): 339-345.
  45. V Biju. “Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy”. Chemical Society Reviews 43 (2014): 744-764.
  46. DA Phoenix., et al. “Photodynamic Antimicrobial Chemotherapy”. Antimicrobe Agents Strategy (2014): 295-330.
  47. P Jia., et al. “Integration of IR-808 and thiol-capped Au-Bi bimetallic nanoparticles for NIR light mediated photothermal/photodynamic therapy and imaging”. Journal of Materials Chemistry 9 (2021): 101-111.
  48. RR Letfullin and TF George. “Computational Nanomedicine and Nanotechnology”. (2016).
  49. S Wood., et al. “Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofilms”. Journal of Antimicrobial Chemotherapy 57 (2006): 680-684.
  50. GB Hwang., et al. “Photobactericidal activity activated by thiolated gold nanoclusters at low flux levels of white light”. Nature Communication 11 (2020): 4-13.
  51. AP Kourtis., et al. “Vital Signs: Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections — United States”. Morbidity and Mortality Weekly Report 68 (2019): 214-219.
  52. KA Jackson., et al. “Invasive Methicillin-Resistant Staphylococcus aureus Infections Among Persons Who Inject Drugs — Six Sites, 2005-2016”. Morbidity and Mortality Weekly Report 67 (2018): 625-628.
  53. KA San and YS Shon. “Synthesis of alkanethiolate-capped metal nanoparticles using alkyl thiosulfate ligand precursors: A method to generate promising reagents for selective catalysis”. Nanomaterials 8 (2018): 1-21.
  54. X Yuan., et al. “Highly luminescent silver nanoclusters with tunable emissions : cyclic reduction - decomposition synthesis and antimicrobial properties”. NPG Asia Material 5 (2013): e39-48.
  55. J Tang., et al. “Ultrasmall Au and Ag Nanoclusters for Biomedical Applications: A Review”. Frontiers in Bioengineering and Biotechnology 8 (2020): 1-12.
  56. SI Chakraborty. As featured in (2013).
  57. G Peng., et al. “Nanosilver at the interface of biomedical applications, toxicology, and synthetic strategies”. Elsevier Inc., (2019).
  58. E Boisselier., et al. “Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity”. Chemical Society Reviews 38 (2009): 1759-1782.
  59. H Bahadar., et al. “Toxicity of nanoparticles and an overview of current experimental models, Iran”. Biomed Journal 20 (2016): 1-11.
  60. HK Patra., et al. “Cell selective response to gold nanoparticles, Nanomedicine Nanotechnology”. Biology and Medicine 3 (2007): 111-119.
  61. CM Goodman., et al. “Toxicity of gold nanoparticles functionalized with cationic and anionic side chains’. Bioconjugate Chemistry 15 (2004): 897-900.
  62. EJ Cho., et al. “Phenanthroline-based magnetic nanoparticles as a general agent to bind histidine-tagged proteins”. Journal of Nanoscience and Nanotechnology 11 (2011): 7104-7107.
  63. RBK C., et al. “Gold nanoparticle-based gene delivery : promises and challenges”. 3 (2014): 269-280.

Citation

Citation: Tatenda Justice Gunda., et al. “A Short Review of Gold-Alkane Thiolate Nanoclusters: Functionalizations, Properties, and Biomedical Applications". Acta Scientific Microbiology 6.3 (2023): 46-54.

Copyright

Copyright: © 2022 Tatenda Justice Gunda., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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