Acta Scientific Microbiology (ISSN: 2581-3226)

Editorial Volume 6 Issue 2

Level Differences of Plasma, Nasal, and Salivary Antibody to SARS-CoV-2 (COVID-19) During Natural Infection and After COVID-19 Vaccination

Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1

1Faculty of Medicine, Western University, Pathumtani Province, Thailand

210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand

3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: December 22, 2022; Published: January 01, 2023

Cellular or antibody responses is measured in the most studies of immunity to SARS-CoV-2 (COVID-19) [1]. Nevertheless, if ever SARS-CoV-2 (COVID-19) present in the plasma, the infectious virus is rarely infects the nasal and conjunctival mucosal surfaces [1]. In COVID-19-infected-unvaccinated and unvaccinated-COVID-19-uninfected individuals, the levels of nasal and salivary anti-spike antibody correlated significantly with plasma antibody [1,2]. The reported mean correlations for titers in plasma and saliva for IgG and IgA were moderate (p = 0.55; 95% CI: 0.38-9.73) and weak (p = 0.28; 95% CI: 0.12-0.44), respectively [2]. A previous systematic review demonstrated that previous-COVID-19-infected-vaccinated individuals demonstrated boosting anti-spike antibody levels in the nose or saliva less than in plasma [1].


  1. Cohen JI., et al. “Comparison of levels of nasal, salivary, and plasma antibody to SARS-CoV-2 during natural infection and after vaccination”. Clinical Infectious Diseases (2022).
  2. Guerra ENS., et al. “Saliva is suitable for SARS-CoV-2 antibodies detection after vaccination: a rapid systematic review”. Frontiers in Immunology (2022).


Citation: Attapon Cheepsattayakorn. “Level Differences of Plasma, Nasal, and Salivary Antibody to SARS-CoV-2 (COVID-19) During Natural Infection and After COVID-19 Vaccination". Acta Scientific Microbiology 6.2 (2023): 01.


Copyright: © 2022 Attapon Cheepsattayakorn. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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