Acta Scientific Microbiology (ISSN: 2581-3226)

Short Communication Volume 6 Issue 1

Microbiota Alterations in Non-Critically-Ill and Critically-Ill COVID-19 Patients

Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1

1Faculty of Medicine, Western University, Pathumtani Province, Thailand

210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand

3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: November 21, 2022; Published: December 16, 2022


The microbiota are related to several human diseases and influence human health [1], figure 1-4. Critical functions of microbiota are decomposition of indigestible proteins, carbohydrates, digestion and absorption of nutrients, host immunity induction, function, and instruction, including vitamin biosynthesis [2-6]. A recent study revealed that gut microbiota (GM) were stratified by occurrence of bloodstream infection (BSI) and intensive-care-unit (ICU) admission (p < 0.05) [7]. ICU patients and those developing BSI were specifically characterized by the over-representation of Enterococcus compared to the respective counterparts (p < 0.001), whereas Clostridiales, Streptococcus, Blautia, Oscillospira, Lachnospiraceae, and other Ruminococcaceae taxa were related to non-ICU-admitted-COVID-19 and non-BSI patients (p < 0.001) [7].


  1. Wang B., et al. “Alterations in microbiota of patients with COVID-19 : potential mechanisms and therapeutic interventions”. Signal Transduction and Targeted Therapy 7 (2022): 143.
  2. Belkaid Y and Harrison OJ. “Homeostatic immunity and the microbiota”. Immunity 46 (2017): 562-576.
  3. Rooks MG and Garrett WS. “Gut microbiota, metabolites and host immunity”. Nature Reviews Immunology 16 (2016): 341-352.
  4. Honda K and Littman DR. “The microbiota in adaptive immune homeostasis and disease”. Nature 535 (2016): 75-84.
  5. Zheng D., et al. “Interaction between microbiota and immunity in health and disease”. Cell Research 30 (2020): 492-506.
  6. Ansaldo E., et al. “Control of immunity by th microbiota”. Annual Review of Immunology 39 (2021): 449-479.
  7. Gaibani P., et al. “The gut microbiota of critically ill patients with COVID-19”. Frontiers in Cellular and Infection Microbiology 11 (2021).
  8. Zuo T., et al. “Alterations in gut microbiota of patients with COVID-19 during time of hospitalization”. Gastroenterology: Basic And Translational-Alimentary Tract 159 (2020): 944-955.


Citation: Attapon Cheepsattayakorn., et al. “Microbiota Alterations in Non-Critically-Ill and Critically-Ill COVID-19 Patients". Acta Scientific Microbiology 6.1 (2023): 32-35.


Copyright: © 2022 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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