Attapon Cheepsattayakorn1,3*, Ruangrong Cheepsattayakorn2 and Porntep Siriwanarangsun3
110th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand 2Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand 3Faculty of Medicine, Western University, Pathumtani Province, Thailand
110th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand
2Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
3Faculty of Medicine, Western University, Pathumtani Province, Thailand
*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.
Received: October 17, 2022; Published: November 01, 2022
Recently, a study demonstrated an engineered banana lectin (BanLec, Lens culinaris) that importantly decreased mitogenicity by replacing histidine 84 with a threonine (H84T-BanLec) and introduction of a single amino acid substitution . H84T-Banlec demonstrated potent broad-spectrum against viruses high-mannose N-glycans (particularly oligomannose-type glycans and GlcNAC at the non-reducing end terminus and artificial mutants at N-/O-linked glycosylation with most potent and broad antiviral activity against the epidemic variants B.1.1.7, B.1.351, and P.1 ), such as severe-acute-respiratory-syndrome coronavirus (SARS-CoV-2 (COVID-19)) and middle-east-respiratory-syndrome coronavirus (MERS-CoV) in vitro and in vivo, in addition to Ebola virus, human immunodeficiency viruses 1 and 2, hepatitis C virus, and influenza viruses A and B, via highly-glycosylated-viral proteins for blocking the cell attachment, cell entry, fusion of membrane, and coronavirus replication [1,3-5]. At 1 mg/mL, lentil lectin revealed no cytotoxic activity and weak hemagglutination . In mouse model, with single injection, no weight loss was identified . Lentil lectin could block inhibit the binding of the human anti-converting-enzyme-2 (ACE 2) receptors to SARS-CoV-2 (COVID-19)-S-trimer protein [2,6]
Citation: Attapon Cheepsattayakorn., et al. “Lentil Lectin, A Molecularly Engineered from Lens culinaris: A Broad-Spectrum Activities Against SARS-CoV-2 (COVID-19)". Acta Scientific Microbiology 5.12 (2022): 01-02.
Copyright: © 2022 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.