Acta Scientific Microbiology (ISSN: 2581-3226)

Editorial Volume 5 Issue 11

Aging Adults with COVID-19 Infection and Alzheimer’s Disease

Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1

1Faculty of Medicine, Western University, Pathumtani Province, Thailand
210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand
3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: September 22, 2022; Published: October 01, 2022


SARS-CoV-2 (COVID-19) demonstrated decrease in the consciousness level [1]. Patients with Alzheimer’s disease (AD) experienced longer lockdown periods to protect themselves from being infected with COVID-19 or to recover from COVID-19 infection [2,3] that contributed to direct results (worse behavioral interferences and more severe neuropsychiatric symptoms) [3]. People with the mid-60’s of ages frequently present the most frequent type of AD that is not produced one gene only (apolipoprotein E gene (APOE)) [4]. Several hypothetically potential pathways are entry via the olfactory system [5,6], blood-brain barrier (BBB) [7,8], and COVID-19-infected-immune cell infiltration [9-11]. Smooth muscle cells in the brain blood vessels express angiotensin-converting-enzyme-2 receptors same as in the pulmonary alveolar cells [12]. Diabetes type 2 (T2D) is a risk factor for both AD and SARS-CoV-2 (COVID-19) via increased activity of interferon-regulatory-factor 5 (IRF5) (Figure 1) [13].


  1. Me´ndez-Gime´nez A. “COVID-19, psychological well-being and physical activity levels in older adults during the nationwide lockdown in Spain”. The American Journal of Geriatric Psychiatry 28 (2020): 1146-1155.
  2. Pe´rez-Rodriguez P., et al. “Impact of social isolation due to COVID-19 on health in older people : mental and physical effects and recommendations”. The Journal of Nutrition, Health and Aging 24 (2020): 938-947.
  3. Numbers K and Brodaty H. “The effects of the COVID-19 pandemic on people with dementia”. Nature Reviews Neurology 17 (2021): 69-70.
  4. Khachaturian ZS. “Calcium, membranes, aging, and Alzheimer’s disease : introduction and overview”. Annals of the New York Academy of Sciences 568 (1989): 1-4.
  5. Butowt R and von Bartheld CS. “Anosmia in COVID-19 : underlying mechanisms and assessment of an olfactory route to brain infection”. Neuroscientist (2020): 1073858420956905.
  6. Dube M., et al. “Axonal transport enables neuron-to-neuron propagation of human coronavirus OC43”. Journal of Virology 92 (2018): e00404-e00418.
  7. Bergmann CC., et al. “Coronavirus infection of the central nervous system : host-virus stand-off”. Nature Reviews Microbiology 4 (2006): 121-132.
  8. Erickson MA and Banks WA. “Neuroimmune axes of the blood-brain barriers and blood-brain interfaces : bases for physiological regulation, disease states, and pharmacological interventions”. Pharmacology Review 70 (2018): 278-314.
  9. Merad M and Martin JC. “Pathological inflammation in patients with COVID-19 : a key role for monocytes and macrophages”. Nature Review on Immunology 20 (2020): 355-362.
  10. Chen R., et al. “The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in the human and mouse brains”. Frontiers in Neurology 11 (2021): 573095.
  11. Kantonen J., et al. “Neuropathologic features of four autopsied COVID-19 patients”. Brain Pathology 30 (2020): 1012-1016.
  12. Hamming I., et al. “Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus : a first step in understanding SARS pathogenesis”. Journal of Pathology 203 (2004): 631-637.
  13. Naughton SX., et al. “Potential novel role of COVID-19 in Aizheimer’s disease and preventative mitigation strategies”. Journal of Alzheimer's Disease 76 (2020): 21-25.


Citation: Attapon Cheepsattayakorn., et al. “Aging Adults with COVID-19 Infection and Alzheimer’s Disease". Acta Scientific Microbiology 5.11 (2022): 01-02.


Copyright: © 2022 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US