Resha Resmawati Shaleha, Anna Yuliana* and Septian Dwi Mulyana

Department of Pharmacochemistry, Tasikmalaya School of Pharmacy BTH, Tasikmalaya, Indonesia

*Corresponding Author: Anna Yuliana, Department of Pharmacochemistry, Tasikmalaya School of Pharmacy BTH, Tasikmalaya, Indonesia.

Received: August 26, 2022; Published: September 30, 2022

Abstract

Background: Corona Virus is biggest family of viruses with causes of illness ranging from mild to severe symptoms. Monascus sp. is used to ferment which has the potential as a Nutraceutical. Studies on Monascus sp. developing rapidly, including the discovery of new pigments, namely 57 derivatives of the pigment Monascus sp. Codes 5LHD and 6VW1 were used as anticoronavirus receptors.

Material and Methods: Ols and SwissDock and then validated by performing Molecular Dynamic. The final conformational results were then visualized using the Biovia Discovery studio, analyzed the effectiveness of the docking program, pharmacokinetics, toxicity, and dynamic programming using the Ramachandran plot.

Results: analysis showed that the compounds derived from Monascus sp. On average it has a small binding affinity value, but the Monankarin E compound has a so good binding affinity value (5LHD: -8.7). Conclusion: Monankarin E from the pigment derivative Monascus sp. can provide good potential to use as a candidate for the anticorona virus.

Keywords: Pigment Monascus sp.; Anticorona Virus; in Silico

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Citation

Citation: Anna Yuliana., et al. “Study In Silico Pigment Derivative Compounds Monascus sp. As Anticorona Virus Candidates". Acta Scientific Microbiology 5.10 (2022): 87-108.

Copyright

Copyright: © 2022 Anna Yuliana., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.