Acta Scientific Microbiology (ISSN: 2581-3226)

Editorial Volume 5 Issue 9

Post-Acute-Sequelae Symptoms of COVID-19 Affected by SARS-CoV-2 (COVID-19) Vaccination

Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1

1Faculty of Medicine, Western University, Pathumtani Province, Thailand

210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand

3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: July 04, 2022; Published: August 01, 2022

Currently, few prospective data that explore the biological mechanisms of the effect of SARS-CoV-2 (COVID-19) vaccination on the persistent symptoms, “long-COVID 19” or “post-acute sequelae of COVID (PASC)”, including compared antibody dynamics between those with and without PASC [1,2]. PASC is defined by symptoms persisting more than 4 weeks after a confirmed or probable COVID-19, without any confirmed alternative diagnosis [1]. Around 52.8% of the patients reported a global effect on symptoms after the vaccine injection, corresponding to a worsening in around 31% and an improvement in around 21.8% [1]. No differences based on the vaccine type used were detected [1]. Around 58.9% of the enrolled subjects developed PASC after at least 3 months of follow-up [2]. Among PASC participants, they revealed the median half-life of RBD- and spike-binding IgG levels of 181 (95% CI: 147-230) and 233 (95% CI: 183-324) days, whereas among those without PASC demonstrated 144 (95% CI: 113-196) and 170 (95% CI: 125-252) days, respectively [2].


  1. Scherlinger M., et al. “Effect of SARS-CoV-2 vaccination on symptoms from post-acute sequelae of COVID-19: results from the nationwide VAXILONG Study”. Vaccines46 (2022): 6.
  2. Wynberg E., et al. “The effect of SARS-CoV-2 vaccination on post-acute sequelae of COVID-19 (PASC) : a prospective cohort study”. Vaccine (2022): 8.


Citation: Attapon Cheepsattayakorn., et al. “Post-Acute-Sequelae Symptoms of COVID-19 Affected by SARS-CoV-2 (COVID-19) Vaccination". Acta Scientific Microbiology 5.9 (2022): 01.


Copyright: © 2022 Attapon Cheepsattayakorn., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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