Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 5 Issue 8

Anti-mullerian Hormone: A Significant Marker for Male Infertility

Olaniru B Olumide1*, Adoga I Godwin2, Johnson O Titilayo2, Isichie O Christian3, Selowo Temitope1, Longkem E Bitrus1, Bot D Yakubu4 and Nengak D Precious1

1Department of Chemical Pathology, Jos University Teaching Hospital Jos, Plateau State, Nigeria

2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Jos, Jos, Plateau State, Nigeria

3Department of Chemical Pathology, Faculty of Clinical Sciences, University of Jos, Jos, Plateau State, Nigeria

4Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, University of Jos, Plateau State, Nigeria

*Corresponding Author: Olaniru B Olumide, Department of Chemical Pathology, Jos University Teaching Hospital Jos, Plateau State, Nigeria.

Received: May 04, 2022; Published: July 06, 2022


A case study was carried to evaluate serum anti-Mullerian hormone (AMH) in men with normal, Oligospermic and Azoospermic sperm as a possible clinical marker for male infertility. The prospective study was conducted on eighty male participants, aged less than 50 years after obtaining ethical approval from the Jos University Teaching Hospital, Jos where the study took place. Infertile men were classified accordingly to their sperm count which was performed according to the World Health Organization (WHO) guidelines into Oligospermic (n = 27) and Azoospermic (n = 23). Thirty men were normal (n = 30). Serum concentrations of follicle stimulating hormone, Testosterone and Anti-Mullerian hormone were measured using ELISA. Results (mean ± SD) revealed that anti-Mullerian hormone (2.02 ± 0.52 ng/ml, p < 0.001) and the testosterone (6.9 ± 1.49 ng/ml, P < 0.001) of control participants were significantly higher than those in both Oligospermic (1.8 ± 0.34 ng/ml, 4.8 ± 0.8 ng/ml) and Azoospermic (1.55 ± 0.29 ng/ml, 2.3 ± 1.2 ng/ml) respectively. The mean serum of Follicle stimulating hormone was significantly reduced in controls (4.8 ± 2.0 miu/ml, p < 0.001) when compared with both Oligospermic (8.5 ± 3.2miu/ml) and Azoospermic (16.5 ± 5.5 miu/ml). anti-Mullerian hormone was negatively correlated with follicle stimulating hormone in both Azoospermic and Oligospermic. Anti-Mullerian hormone should be evaluated in patients with oligospermia and azoospermia. It may serve as a marker of infertility.

Keywords: Anti-Mullerian; Hormone; Marker; Male Infertility


  1. Razieh Dehghani-Firouzabadi., et al. “Serum Level of Anti-Mullerian Hormone in Early Follicular Phase as a predictor of Ovarian Reserve and Pregnancy Outcome in Assisted Reproductive Technology Cycles”. Archives of Iranian Medicine 4 (2008): 371-376.
  2. Jang H Kim. “Mullerin inhibiting substance: physiology and clinical application”. Journal of Women Medicine2 (2014): 45-47.
  3. La Marca A., et al. “Anti-Mullerian Hormone (AMH): what do we still need to know?” Human Reproduction 9 (2009): 2264-2275.
  4. Rajpert-De Meyts E., et al. “Expression of Anti-Mullerian Hormone during Normal and Pathological Gonadal Development: Association with Differentiation of Sertoli and Granulosa Cells”. The Journal of Clinical Endocrinology and Metabolism10 (1999): 3836-3844.
  5. Salva A., et al. “Mullerian-inhibiting substance inhibits rats Leydig cell regeneration after ethylene dimethanesulphonate ablation”. Biological Reproduction 70 (2004): 600-607.
  6. Maymon BB., et al. “Sertoli cells Maturation in men with azoospermia of different etiologies”. Fertility and Sterility5 (2002): 904-909.
  7. Al-Qahtani A., et al. “Development of a sensitive enzyme immunoassay for anti-mullerian hormone and the evaluation of potential clinical applications in males and females”. Clinical Endocrinology3 (2005): 267-273.
  8. Tuttelmann F., et al. “Anti-Mullerian hormone in men with normal and reduced sperm concentration and men with maldescended testes”. Fertility and Sterility 5 (2009): 1812-1818.
  9. Young J., et al. “Anti-Mullerian hormone in patients with hypogonadrotopic hypogonadism”. Journal of Clinical Endocrinology and Metabolism 8 (1999): 2696-2699.
  10. Appasamy M., et al. “Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility”. Reproductive Biomedcine online 2 (2007): 159-165.
  11. Fuji SM., et al. “The significance of Anti-mullerian Hormone concentration in seminal plasma for spermatogenesis”. Human Reproduction 4 (2002): 968-970.


Citation: Olaniru B Olumide., et al. “Anti-mullerian Hormone: A Significant Marker for Male Infertility". Acta Scientific Microbiology 5.8 (2022): 02-04.


Copyright: © 2022 Olaniru B Olumide., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US