Olaniru B Olumide¹*, Adoga I Godwin², Johnson O Titilayo², Isichie O Christian³, Selowo Temitope¹, Longkem E Bitrus¹, Bot D Yakubu⁴ and Nengak D Precious¹

¹Department of Chemical Pathology, Jos University Teaching Hospital Jos, Plateau State, Nigeria

*Corresponding Author: Olaniru B Olumide, Department of Chemical Pathology, Jos University Teaching Hospital Jos, Plateau State, Nigeria.

Received: May 04, 2022; Published: July 06, 2022

Abstract

A case study was carried to evaluate serum anti-Mullerian hormone (AMH) in men with normal, Oligospermic and Azoospermic sperm as a possible clinical marker for male infertility. The prospective study was conducted on eighty male participants, aged less than 50 years after obtaining ethical approval from the Jos University Teaching Hospital, Jos where the study took place. Infertile men were classified accordingly to their sperm count which was performed according to the World Health Organization (WHO) guidelines into Oligospermic (n = 27) and Azoospermic (n = 23). Thirty men were normal (n = 30). Serum concentrations of follicle stimulating hormone, Testosterone and Anti-Mullerian hormone were measured using ELISA. Results (mean ± SD) revealed that anti-Mullerian hormone (2.02 ± 0.52 ng/ml, p < 0.001) and the testosterone (6.9 ± 1.49 ng/ml, P < 0.001) of control participants were significantly higher than those in both Oligospermic (1.8 ± 0.34 ng/ml, 4.8 ± 0.8 ng/ml) and Azoospermic (1.55 ± 0.29 ng/ml, 2.3 ± 1.2 ng/ml) respectively. The mean serum of Follicle stimulating hormone was significantly reduced in controls (4.8 ± 2.0 miu/ml, p < 0.001) when compared with both Oligospermic (8.5 ± 3.2miu/ml) and Azoospermic (16.5 ± 5.5 miu/ml). anti-Mullerian hormone was negatively correlated with follicle stimulating hormone in both Azoospermic and Oligospermic. Anti-Mullerian hormone should be evaluated in patients with oligospermia and azoospermia. It may serve as a marker of infertility.

Keywords: Anti-Mullerian; Hormone; Marker; Male Infertility

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Citation

Citation: Olaniru B Olumide., et al. “Anti-mullerian Hormone: A Significant Marker for Male Infertility". Acta Scientific Microbiology 5.8 (2022): 02-04.

Copyright

Copyright: © 2022 Olaniru B Olumide., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.