Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 5 Issue 6

Nutrient Availability Impacts Intracellular Metabolic Profiles in Digital Organisms

Katheresan S Sooriya Kannan1,2, Tanmay Patil1,2, Rohit Vij1,2, Behnjemyn JK Loh1,2 and Maurice HT Ling1,2,3,4*

1School of Life Sciences, Management Development Institute of Singapore, Singapore

2School of Applied Sciences, Northumbria University, United Kingdom

3School of Data Sciences, Perdana University, Malaysia

4HOHY PTE LTD, Singapore

*Corresponding Author: Maurice HT Ling, School of Life Sciences, Management Development Institute of Singapore, Singapore.

Received: April 26, 2022; Published: May 13, 2022


The ability of organisms to utilize environmental chemicals as nutrients and adapt to changes in nutrient availability is a hallmark of life. Yet despite different environments, the concentration and osmolarity of intracellular metabolites are relatively constant across different organism. Although adaptation experiments can be performed, they are usually labour intensive and must be carried out in stepwise or gradual manner. On the other hand, digital organisms or computer-simulated organisms can be used to study adaptations to extreme conditions. Here, we examine the effects of nutrient levels on the metabolic profiles of organisms. Our results show that nutrient availability results in significantly different average intracellular metabolite amounts (F = 5166, p-value < 1E-200) at 1500th generation despite the range within one order but there is significant decline of the impact of nutrient availability on the amounts of intracellular metabolites with increasing generations (r = -0.995, F = 385, p-value = 3.98E-05). However, mean intracellular amounts of specific metabolites are significantly different across all 12 nutrient availabilities (14 ≤ F ≤ 1927, 4.1E-304 ≤ p-value ≤ 1.6E-22). This suggests that the impact of nutrient availability is beyond the overall intercellular metabolite amounts but at the level of individual metabolites.

Keywords: Organisms; Metabolism; Nutrients


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Citation: Maurice HT Ling., et al. “Nutrient Availability Impacts Intracellular Metabolic Profiles in Digital Organisms". Acta Scientific Microbiology 5.6 (2022): 18-25.


Copyright: © 2022 Maurice HT Ling., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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