Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 5 Issue 6

COVID-19 Variants: Molecular Insight into Mutations

Nikku Yadav1*, Suman Bala2, Charu Rai3, Lovnish Thakur4 and Nidhi Yadav5

1Assistant Professor (Clinical Research), Department of Community Medicine, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India

2Professor, Department of Pharmacology, Swami Rama Himalayan University, Uttarakhand, India

3Independent Researcher, M.Sc. Biotechnology from Apeejay Stya University, India

4Junior Research Fellow, NGIVD, BSC BioNest Bio-Incubator NCR Biotech Science Cluster, NCR Delhi, India

5Junior Research Fellow, Swami Rama Himalayan University, Uttarakhand, India

*Corresponding Author: Nikku Yadav, Assistant Professor (Clinical Research), Department of Community Medicine, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India.

Received: April 27, 2022; Published: May 12, 2022

Abstract

The purpose of this study was to summarize the knowledge available on mutations in SARS Cov-2 variants which can help in understanding the mutation pattern and to aid new drug development. Further, we have tried to gather the information available regarding the latent variants i.e. Omicron and IHU variants. So, for this, we have used databases like GISAID and Next strain to get the mutation information. And we have also done a sequence similarity search of emerging variants with the Wuhan reference strains. Also, we have discussed the latest WHO guidelines that need to be followed to tackle this 3rd wave of Covid-19.

Keywords:Mutations; SARS Cov-2 Variants; Doubling Time; Spike Structure

References

  1. Lavazza A and Farina M. “The Role of Experts in the Covid-19 Pandemic and the Limits of Their Epistemic Authority in Democracy”. Frontiers in Public Health 8 (2020).
  2. Guo YR., et al. “The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status”. Military Medical Research 7 (2020): 11.
  3. Sharma R., et al. “Clinical Characteristics and Differential Clinical Diagnosis of Novel Coronavirus Disease 2019 (COVID-19)”. Coronavirus Disease 2019 (COVID-19) (2020): 55-70.
  4. Harvey WT., et al. “SARS-CoV-2 variants, spike mutations and immune escape”. Nature Reviews Microbiology 19 (2021): 409-424.
  5. Kandeel, M., et al. “Omicron variant genome evolution and phylogenetics”. Journal of Medical Virology (2021).
  6. Coronavirus Disease 2019 (COVID-19) Daily Research Briefs.
  7. Pulliam JRC., et al. “Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa”. (2021): 2021.2011.2011.21266068.
  8. Collie S., et al. “Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa”. New England Journal of Medicine (2021).
  9. Katella K. “Comparing the COVID-19 Vaccines: How Are They Different?”
  10. Colson P., et al. “Emergence in Southern France of a new SARS-CoV-2 variant of probably Cameroonian origin harbouring both substitutions N501Y and E484K in the spike protein”. (2021): 2021.2012.2024.21268174.
  11. Shadmi E., et al. “Health equity and COVID-19: global perspectives”. International Journal of Equity Health 19 (2020): 104-104.
  12. Han E., et al. “Lessons learnt from easing COVID-19 restrictions: an analysis of countries and regions in Asia Pacific and Europe”. The Lancet 396 (2020): 1525-1534.

Citation

Citation: Nikku Yadav., et al. “COVID-19 Variants: Molecular Insight into Mutations". Acta Scientific Microbiology 5.6 (2022): 08-17.

Copyright

Copyright: © 2022 Nikku Yadav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days

Indexed In






News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US