Acta Scientific Microbiology (ISSN: 2581-3226)

Short Communication Volume 5 Issue 1

Whipple’s Disease-An Enigmatic Diagnostic Challenge Despite a Centenary of the Detection of the Etiologic Agent-A Short Communication

Kulvinder Kochar Kaur1* Gautam Allahbadia2 and Mandeep Singh3

1Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Ex-Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India

*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.

Received: December 29, 2021; Published: January 31, 2021

Whipples disease (WD) represents a chronic infectious disease that was initially detailed by George Whipple in 1907. As per Whipple the intestinal lipodystrophy that was visualized was secondary to the aberrant lipid metabolism as well as not an infection. In 1952 it was thought to be due to bacterial causation along with antibiotic therapy attempt seemed to bring success. Nevertheless, it was only in 1992, that the bacteria got isolated with name of Tropheryma whipplei got assigned, whereas in 2001 again the name was altered to Tropheryma whipplei that was thought to be the correct spelling [1].


  1. Dutly F., et al. “Whipples disease and ‘’Tropheryma whipplei’’. Clinical Microbiology Reviews 14 (2001): 561-583.
  2. Biagi F., et al. “Prevalence of Whipples disease in north wester n Italy”. European Journal of Clinical Microbiology and Infectious Diseases 34 (2015): 1347-1348.
  3. Hujoel JA., et al. “Tropheryma whipplei’’ infection (Whipples disease) in the USA”. Digestive Diseases and Sciences 64 (2019): 213-223.
  4. Marth T. “Tropheryma whipplei. Immunosuppression and Whipples disease:from a low pathogenesic environmental infectious organism to a rare ,multifaceted inflammatory complex”. Digestive Diseases 33 (2015): 190-199.
  5. Marth T., et al. “Tropheryma whipplei infection and Whipples disease”. The Lancet Infectious Diseases 16 (2016): e13-e22.
  6. Cardoso J., et al. “Whipples disease:a rare cause of mal absorption syndrome”. The GE - Portuguese Journal of Gastroenterology 27 (2020): 283-289.
  7. Saito H., et al. “Whipples disease with longterm endoscopic follow up”. Internal medicine 57 (2018): 1707-1713.
  8. Dolmans RA., et al. “Clinical manifestation, treatment and diagnosis of ’Tropheryma whipplei’’ infection”. Clinical Microbiology Reviews 14 (2001): 561-583.
  9. Apstein MD and Schneider T. “Whipple’s disease”. UpToDate. Wolters Kluwer, Waltham, MA (2016).
  10. Feurle GE., et al. “Efficacy of ceftriaxone or meropenemas initial therapies in Whipple’s disease”. Gastroenterology 138 (2010): 478-486.
  11. Puechal X. “Whipple’s disease”. Annals of the Rheumatic Diseases 72 (2013): 797-803.
  12. Fenollar F., et al. “Whipple’s disease”. The New England Journal of Medicine 356 (2007): 55-66.
  13. Turcan S., et al. “Whipples disease? a case report and discussion”. Medicine and Pharmacy Reports1 (2021): S76-S78.


Citation: Kulvinder Kochar Kaur., et al. “Whipple’s Disease-An Enigmatic Diagnostic Challenge Despite a Centenary of the Detection of the Etiologic Agent-A Short Communication". Acta Scientific Microbiology 5.2 (2022): 116-119.


Copyright: © 2022 Kulvinder Kochar Kaur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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