Hanan K Bokhamada, Intesar Ahmad Hasan Elmasli and Hind A Elzletni*

Biology Department, Faculty of Education, University of Benghazi, Benghazi, Libya

*Corresponding Author: Hind A Elzletni, Biology Department, Faculty of Education, University of Benghazi, Benghazi, Libya.

Received: September 06, 2021; Published: September 25, 2021

Citation: Hind A Elzletni., et al. “The Comparative Between Gut Microbiota in Type 2 Patients Diabetes and Health People". Acta Scientific Microbiology 4.10 (2021):.

Abstract

The Diabetes it is a major contributor to the development of many pathological ‎processes including hypertension, hyperlipidemia, and cardiovascular diseases. ‎both animal and human studies indicates that gut ‎microbial change is associated with diabetes, but such an association with T2DM in Libyan people is not known. Therefore, the aim of present study is to recognize if ‎there is a difference in the bacterial composition between Libyan diabetic patients and ‎a healthy control. Also, to find whether there is a relationship between bacterial ‎composition and diverse factors such as FBS, HbA1c, and lipid profile and ‎body composition. Two groups of participated in this study including 20 ‎patients with type 2 diabetes and 28 healthy control subjects were involved. ‎The fecal microbiota structure at level of species was investigated by using ‎conventional culture method. There was significant difference in gut bacteria ‎between diabetic patients and healthy control. The relative abundance of B. ‎vulgatus, and B. rodentium were significantly declined in the diabetic group ‎compared to non-diabetic group (P = 0.008, P = 0.018) but B. vulgatus ‎negatively and significantly correlated to level of HDL-C (P = 0.015). Moreover, ‎the relative abundance of L. acidophilus reduced significantly (P = 0.02) and ‎correlated positively and significantly with Fasting blood sugar (P = 0.001) ‎and HbA1c (P = 0.016) in diabetic patients compared to the healthy control ‎group. Our results show that T2DM is associated with compositional ‎alterations in gut microbiota. B. vulgatus, B. rodentium and L. acidophilus B. ‎may be possible indicators of T2DM. The interaction of specific gut microbiota ‎with FBG, HbA1c, and HDL-C should be considered as potential interest for ‎future studies to develop better approaches for the prevention and treatment of ‎T2DM by modulation of gut microbiota. ‎

Keywords: Diabetes; Gut Microbiota; FSB; HbA1c; Lipid Profile

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Copyright: © 2021 Hind A Elzletni., et al. “Recombinant Vaccines - Rise of a New Era of Vaccination". This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.