Acta Scientific Microbiology (ISSN: 2581-3226)

Review ArticleVolume 4 Issue 10

The Role of Pd-L1 on Tumor Cells in Host Immune System Escape and Tumor Immunotherapy by Pd-L1 Blockade; Immune Checkpoint Blockade in Cancer Immunotherapy

Mehmet Eraslan*

Çanakkale Onsekiz Mart University, Faculty of Science and Literature, Turkey

*Corresponding Author: Mehmet Eraslan, Çanakkale Onsekiz Mart University, Faculty of Science and Literature, Turkey.

Received: August 26, 2021; Published: September 15, 2021

Citation: Mehmet Eraslan. “The Role of Pd-L1 on Tumor Cells in Host Immune System Escape and Tumor Immunotherapy by Pd-L1 Blockade; Immune Checkpoint Blockade in Cancer Immunotherapy". Acta Scientific Microbiology 4.10 (2021): 45-55.


  Immune checkpoints are a group of inhibitory mechanisms that are encoded into the immune system. Mice treated with anti-PD L1 or PD-1-deficient animals showed increased tumorigenesis and invasiveness in syngeneic hosts when compared to parental tumor cells lacking PD-L. The classical type of programmed cell death is distinguished by its morphological hallmarks of apoptosis and its reliance on de novo RNA and protein production. The PD-1 gene was active in both stimulated 2B4.11 and IL-3-depleted LyD9 cells. The findings imply that the genetic landscape of lung malignancies influences anti-PD-1 therapeutic responsiveness. Immune resistance can be overcome by blocking the inhibitory receptor programmed death 1 (PD-1), which is produced by T cells. An antibody that precisely targets PD-1, was considered for anticancer efficacy and safety. There is a link between PD-L1 expression on tumor cells and objective response. In patients with advanced malignancies such as non-small cell lung cancer, melanoma, and renal-cell cancer, antibody-mediated PD-L1 inhibition resulted in long-term tumor shrinkage and disease stability.

Keyword: Immunotherapy; PD-1 and PD-L1; Anti-PD-L1; Cancer; Blockade of CTLA-4; Tumor


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Copyright: © 2021 Mehmet Eraslan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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