Acta Scientific Microbiology (ISSN: 2581-3226)

Review ArticleVolume 4 Issue 10

Role of Colostrum in Immune-Protection and Disease Prevention in Neonates and their Post Natal Life

Ravi Kant Upadhyay*

Department of Zoology, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, UP, India

*Corresponding Author: Ravi Kant Upadhyay, Department of Zoology, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, UP, India.

Received: August 16, 2021; Published: September 08, 2021

Citation: Ravi Kant Upadhyay. “Role of Colostrum in Immune-Protection and Disease Prevention in Neonates and their Post Natal Life". Acta Scientific Microbiology 4.10 (2021): 11-17.

Abstract

  Colostrum is naturally secreted nutritionally rich thick biological fluid that contains various bioactive molecules such as proteins, carbohydrates, fats, hormones, growth factors, vitamins, lectoferrins, and good repertoire of immunoglobulins which play important role in innate immune defense in new born infants. It contains disease protective and growth promoting micro and macronutrients. Colostrum or milk suckling by mammalian new born babies is a unique phenomenon as it passively transfers important growth factors, which are highly essential for maturation and post natal development. Presence of IgA, IgG and IgM in colostrums protects new born babies from gut mucosal microbial infection. It is highly beneficial for health of sport persons and has high therapeutic value. Commercial storage of colostrums can be used for long term treatment of preterm babies, immunocompromised patients and elderly. Hence, sterilize colostrum collection systems be developed for its clinical and therapeutic use. More specially, for preterm babies constitutive colostrum feeds can be generated with infant formula to protect them from microbial gut infection mainly colonizing bacteria at larger scale. Present review is emphasizing benefits of breast feeding in newborn infants and sketches out immune-protective, nutritional and growth promoting properties of colostrums.

Keywords: Colostrum; Nutritional Value; Immunoglobulins; Innate Immune Defense; Disease Prevention and Therapeutic Uses

Bibliography

  1. Williams DR., et al. “Effect of Three Colostrum Diets on Passive Transfer of Immunity and Preweaning Health in Calves on a California Dairy following Colostrum Management Training”. Veterinary Medicine International 2014 (2014).
  2. Li Y., et al. “Bovine Colostrum Before or After Formula Feeding Improves Systemic Immune Protection and Gut Function in Newborn Preterm Pigs”. Frontiers in Immunology 10 (2020): 3062.
  3. Hurley WL., et al. “Perspectives on Immunoglobulins in Colostrum and Milk”. Nutrients4 (2011): 442-474.
  4. Sears KT., et al. “Bioactive Immune Components of Anti-Diarrheagenic Enterotoxigenic Escherichia coli Hyperimmune Bovine Colostrum Products”. Clinical and Vaccine Immunology 8 (2017).
  5. Liermann W., et al. “Effects of colostrum instead of formula feeding for the first 2 days postnatum on whole-body energy metabolism and its endocrine control in neonatal calves”. Journal of Dairy Science4 (2020): 3577-3598.
  6. Sandra M Godden., et al. “Colostrum management for dairy calves”. Veterinary Clinics of North America: Food Animal Practice3 (2019): 535-556.
  7. Ulfman LH., et al. “Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection”. Frontiers in Nutrition 5 (2018): 52.
  8. Bagwe-Parab S., et al. “Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal Diseases and Distinctive Cancer Types: The Current Evidence”. Frontiers in Pharmacology 11 (2020): 01100.
  9. Wakabayashi Hiroyuki., et al. “Inhibition of Iron/Ascorbate-Induced Lipid Peroxidation by an N-Terminal Peptide of Bovine Lactoferrin and Its Acylated Derivatives". Bioscience, Biotechnology, and Biochemistry5 (1999): 955-957.
  10. Gutteridge J M and Smith. "Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation". Biochemical Journal3 (1988): 861-865.
  11. da Cruz Martins C., et al. “Colostrum oropharyngeal immunotherapy for very low birth weight preterm infants: protocol of an intervention study”. BMC Pediatrics 20 (2020).
  12. Sinanoglou VJ. “Factors affecting human colostrum fatty acid profile: A case study”. PLoS One4 (2017).
  13. Li Y., et al. “Bovine Colostrum Before or After Formula Feeding Improves Systemic Immune Protection and Gut Function in Newborn Preterm Pigs”. Frontiers in Immunology 10 (2020): 3062.
  14. Jawhara S., et al. “Can Drinking Microfiltered Raw Immune Milk From Cows Immunized Against SARS-CoV-2 Provide Short-Term Protection Against COVID-19?”. Frontiers in Immunology 11 (2020).
  15. Arslan A., et al. “Bovine Colostrum and Its Potential for Human Health and Nutrition”. Frontiers in Nutrition 8 (2020).
  16. Tassiane C Morais., et al. “Melatonin Action on the Activity of Phagocytes from the Colostrum of Obese Women”. Medicina (Kaunas) 10 (2019): 625.
  17. Puppel K., et al. “Composition and Factors Affecting Quality of Bovine Colostrum: A Review”. Animals (Basel) 12 (2019): 1070.
  18. Bardanzellu F., et al. “Omics in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes”. Nutrients8 (2017): 843.
  19. Munblit D., et al. “Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy”. Nutrients9 (2018): 1216.
  20. Kasonta R., et al. “Colostrum from Cows Immunized with a Vaccine Associated with Bovine Neonatal Pancytopenia Contains Allo-Antibodies that Cross-React with Human MHC-I, Molecules”. PLoS One10 (2014).
  21. Kaplan DS., et al. “Colostrum immunoglobulins and oxidative capacity may be affected by infant sex and maternal age and parity”. Turkish Journal of Medical Sciences 1 (2019): 87-92.
  22. Soufleri A., et al. “Evaluation of Factors Affecting Colostrum Quality and Quantity in Holstein Dairy Cattle”. Animals (Basel)7 (2021): 2005.
  23. Filipescu IE., et al. “Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice”. PLoS One8 (2018).
  24. Sánchez-Salguero E., et al. “Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum”. Maternal Health, Neonatology and Perinatology 5 (2019).
  25. Larcombe S., et al. “Hyperimmune bovine colostrum reduces gastrointestinal carriage of uropathogenic Escherichia coli”. Human Vaccines and Immunotherapeutics2 (2018): 508-513.
  26. March DS., et al. “The effect of bovine colostrum supplementation on intestinal injury and circulating intestinal bacterial DNA following exercise in the heat”. European Journal of Nutrition4 (2019): 1441-1451.
  27. Short DM., et al. “A Randomized Clinical Trial Evaluating the Effects of Oligosaccharides on Transfer of Passive Immunity in Neonatal Dairy Calves”. Journal of Veterinary Internal Medicine 4 (2016): 1381-1389.
  28. Konishi M., et al. “The effectiveness of colostral antibodies for preventing bovine leukemia virus (BLV) infection in vitro”. BMC Veterinary Research 14 (2018).
  29. Parreño V., et al. “Modulation by colostrum-acquired maternal antibodies of systemic and mucosal antibody responses to rotavirus in calves experimentally challenged with bovine Rotavirus”. Veterinary Immunology and Immunopathology1 (2004): 7-24.
  30. Civra A., et al. “Colostrum from cows immunized with a veterinary vaccine against bovine rotavirus displays enhanced in vitro anti-human rotavirus activity”. Journal of Dairy Science6 (2019): 4857-4869.
  31. Ellis JA., et al. “Bovine respiratory syncytial virus-specific IgG-1 in nasal secretions of colostrum-fed neonatal calves”. Canadian Veterinary Journal 5 (2018): 505-508.
  32. Drikic M., et al. “Determining the IgG concentrations in bovine colostrum and calf sera with a novel enzymatic assay”. Journal of Animal Science and Biotechnology 9 (2018): 69.
  33. , et al. “Restricted isotype, distinct variable gene usage, and high rate of gp120-specificity of HIV-1 Envelope-specific B cells in colostrum compared to those in blood of HIV-1-infected, lactating African women”. Mucosal Immunology 8.2 (2015): 316-326.
  34. Jeffries TL., et al. “The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells”. Mucosal Immunology2 (2016): 414-427.
  35. Grześkowiak Ł., et al. “Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium against Clostridioides (syn. Clostridium) difficile Toxin-Induced Effects”. Microorganisms1 (2020): 142.
  36. Francese R., et al. “Anti-Zika virus and anti-Usutu virus activity of human milk and its components”. PLOS Neglected Tropical Diseases 10 (2020).
  37. Niyazbekova Z., et al. “Compositional and Functional Comparisons of the Microbiota in the Colostrum and Mature Milk of Dairy Goats”. Animals (Basel)11 (2020): 1955.
  38. Sienkiewicz M., et al. “Supplementation of Bovine Colostrum in Inflammatory Bowel Disease: Benefits and Contraindications”. Advances in Nutrition2 (2020): 533-545.
  39. Chandwe K., et al. “Colostrum Therapy for Human Gastrointestinal Health and Disease”. Nutrients 6 (2021).
  40. Glen Davison. “The Use of Bovine Colostrum in Sport and Exercise”. Nutrients6 (2021): 1789.
  41. Abdelmeguid NE. “Ameliorative effects of colostrum against DMBA hepatotoxicity in rats”. Saudi Journal of Biological Sciences 4 (2021): 2254-2266.
  42. Kociszewska-Najman B., et al. “Does Caesarean Section or Preterm Delivery Influence TGF-β2 Concentrations in Human Colostrum?” Nutrients 4 (2020): 1095.
  43. Forner R., et al. “Distribution difference of colostrum-derived B and T cells subsets in gilts and sows”. PLoS One5 (2021).
  44. Ferrari DVde J., et al. “Profile of pro-inflammatory cytokines in colostrum of nursing mothers at the extremes of reproductive age”. PLoS One 6 (2020).
  45. Laskowska E., et al. “Effect of Multi-Microbial Probiotic Formulation Bokashi on Pro- and Anti-Inflammatory Cytokines Profile in the Serum, Colostrum and Milk of Sows, and in a Culture of Polymorphonuclear Cells Isolated from Colostrum”. Probiotics Antimicrobe Proteins1 (2019): 220-232.
  46. Playford RJ., et al. “Bovine Colostrum: Its Constituents and Uses”. Nutrients 1 (2021): 265.
  47. Lisa Robbers., et al. “A Scoping Review of On-Farm Colostrum Management Practices for Optimal Transfer of Immunity in Dairy Calves”. Frontiers in Veterinary Science 8 (2021): 668639.
  48. Skarpańska-Stejnborn A., et al. “Effects of Long-Term Supplementation of Bovine Colostrum on the Immune System in Young Female Basketball Players. Randomized Trial”. Nutrients 1 (2020): 118.
  49. Alexandria I Kristensen-Cabrera., et al. “A prospective clinical study of Primo-Lacto: A closed system for colostrum collection”. PLoS One11 (2018): e0206854.
  50. Johnsen JF., et al. “A cross-sectional study of suckling calves’ passive immunity and associations with management routines to ensure colostrum intake on organic dairy farms”. Acta Veterinaria Scandinavica 61 (2019): 7.

Copyright: © 2021 Ravi Kant Upadhyay. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US