Ferez Soli Nallaseth*, David Adebayo, Syed M Ahmed, Kholis Abdurachim Audah, Deepak Bhatia, Vitaly Boyko, Alex Diaz, Abhishek Gupta, Mirhasan H Hasanli, Percy Ichchaporia, Zeeshan Khan, Anthony Lai, Lori McGrew, Shin Mukai, Dickson Achimugu Musa, Srinath Nissankararao, Elizabeth Parrish, George Perry, Jean Plante, Asmaa Rabit, David Sherman, Ralph Sherman, Sandeep Kumar Singh, Sina Varmaghani, Collin C White, Nirmali Wijegoonawardana, Hafiz Shaeque Yahya and Osama Youssef

#1, #2Life Sciences Institute of New Jersey (LSINJ), 2468 US Route 206, PO Box 1367, Belle Mead, NJ 08506 - 6430, USA.
Full positions and external affiliations of current and former Board Members of the LSINJ:
#1https://www.lifesciencesinstitutenj.com/board-members
#2https://www.lifesciencesinstitutenj.com/board-members-on-sabbatical#h.hwbm7od8kmzh

*Corresponding Author: Ferez Soli Nallaseth, Founding President, CEO, CSO and CFO for the LSINJ, USA. Postal Addresses: Life Sciences Institute of New Jersey, Email: FerezNallaseth@LifeSciencesInstituteNJ.com; fereznal25@lsinj.org

Received: August 07, 2021; Published: August 13, 2021

Citation: Ferez Soli Nallaseth., et al. “Akin to the Great Revolutions or Ages, the Combinatorial Approach for Preempting Genetic Diseases Requires the Confluence of Independent Scientific and Societal Developments Emerging from Synergisms Between Serendipitous, Planned and Natural Progressions Significantly Magnifying the Impact Over the Simple Sum of their Individual Components or Subfields". Acta Scientific Microbiology 4.9 (2021): 105-120.

Abstract

At least 65% of all diseases have a genetic component caused by the insertion of a genetic lesion into the genome as a consequence of the dysregulation of networks of genes for its maintenance. In the long term, a system for preempting these lesions in real time would have an unparalleled and positive impact on Medicine and Humankind. Including in ameliorating Human and Economic burdens on a scale of hundreds of trillions of dollars per annum. Assembling this system is indispensable for the Public Interest but subject to benign, if not optimistic, neglect. Many of the sciences, methods and elements of methods for initiating this assembly are available, or in development or conceivable by integrating and synthesizing an array of sub fields in the Life, Physical and Computational Sciences and Mathematics. The process depends as much on good planning as it does on serendipitous discoveries which represent the underpinnings of civilization. The assembly of the system for preempting genetic diseases is akin to those defining epochs or periods on a historical scale. Including the Renaissance, Industrial Revolution, Information Age, Space Age, Green Revolution and Biotech Revolution. All of which are far greater than the sum of their many components and vectors comprising of discoveries, inventions, explorations, planned progressions and of equal significance either serendipitous findings or unforeseeable consequences. All of which underlie civilization in all its dimensions. This is due to the simple reason that all of these vectors and components play associative, combinatorial, synergistic and complementary roles which together magnify the sum of the results of these progressive processes.

Keywords: Evolutionary & Mouse Genetics, Speciation; dysregulating Chromosome/Genome Biology; Mutome; Integration of Subfields of Life, Physical & Computational Sciences; Combinatorial Approach in Real Time Operations, Preemption of Genetic Diseases; Human, Health & Economic Costs & Burdens

Bibliography

1. https://www.lifesciencesinstitutenj.com/
2. Nallaseth FS. Extracted from MOJPB eBook. “Shifting the therapeutic paradigm in medicine from post mutational (& pathological) intervention to preemption - a synopsis of the ‘nuts and bolts”. MOJ Proteomics and Bioinformatics2(2019):1-840.
3. https://www.lifesciencesinstitutenj.com/webinars-scheduled-delivered-by-lsinj-board-members-from-global-sites#h.iywoseh4jkp2
4. https://www.lifesciencesinstitutenj.com/webinars-scheduled-delivered-by-lsinj-board-members-from-global-sites#h.qmpsot4an5dm
5. https://www.lifesciencesinstitutenj.com/webinars-scheduled-delivered-by-lsinj-board-members-from-global-sites#h.6ucilopq1vgf
6. Nallaseth FS. “Shifting the therapeutic paradigm in medicine from post mutational (& pathological) intervention to preemption - a synopsis of the ‘nuts and bolts”. (in preparation, 2021) MOJPB eBook (2021): 1-840.
7. https://academic.oup.com/mbe/article/9/2/331/971969
8. https://www.hilarispublisher.com/open-access/is-there-a-role-for-an-evolutionary-genetics-based-rational-health-policy-2168-9547.1000e118.pdf
9. https://www.linkedin.com/pulse/why-functional-indispensable-moiety-genomics-nallaseth-m-s-ph-d-?trk=portfolio_article-card_title
10. https://sites.google.com/site/nallasethfs/home/pdf-documents
11. https://scholar.google.com/scholar?hl=en&as_sdt=0%2C31&q=Nallaseth+FS&btnG=&oq=Nallaseth+FS
12. https://www.researchgate.net/profile/Ferez-Nallaseth
13. https://www.google.com/search?client=firefox-b-1-d&q=species+incompatibility
14. https://www.linkedin.com/pulse/upcoming-posts-classical-passe-vs-contemporary-ii-ferez-soli?trk=portfolio_article-card_title
15. https://www.linkedin.com/pulse/mcclintock-mintz-again-interspecific-combinations-y-ferez-soli?trk=portfolio_article-card_title
16. https://www.linkedin.com/pulse/neither-new-nor-surprising-we-showed-interspecific-ferez-soli?trk=portfolio_article-card_title
17. Coyne JA and Orr HA. “Speciation”. Publishers Sinauer Associates, Inc, Sunderland, MA, USA, (a) Chapter 8, The genetics of Post-zygotic Isolation, (Table 2, Pg 302) Pgs 283 - 319, (b) Chapter 9, Polyploidy and Hybrid Speciation (2004): 320 - 351.
18. https://www.google.com/search?q=Sex+Determination&client=firefox-b-1-d&sxsrf=ALeKk03xTyYRXh_mmuCXqUCJOW4YD1P3yg%3A1625482453221&ei=1eTiYMWADce0tAaTtKHgDg&oq=Sex+Determination&gs_lcp=Cgdnd3Mtd2l6EAMyBAgAEEMyAggAMgIIADICCAAyAggAMgIIADICCAAyAggAMgIIADICCAA6BwgAEEcQsAM6BAgjECc6BQgAEJECOgUIABCxAzoICC4QxwEQowI6CAguELEDEIMBOgsILhCxAxDHARCjAjoOCC4QsQMQgwEQxwEQrwE6BQguELEDOggIABCxAxCDAToFCAAQyQM6BQgAEJIDOgIILkoECEEYAFDJwgFYvOUBYM_qAWgBcAJ4AIABYIgBngqSAQIxOJgBAKABAaoBB2d3cy13aXrIAQjAAQE&sclient=gws-wiz&ved=0ahUKEwiFv9mB4svxAhVHGs0KHRNaCOwQ4dUDCA0&uact=5
19. https://www.google.com/search?q=Speciation&client=firefox-b-1-d&sxsrf=ALeKk0056FLWa1XhP3LF_F5cGws78kL8dQ%3A1625482484176&ei=9OTiYIyhCoaztQbsw4a4Cw&oq=Speciation&gs_lcp=Cgdnd3Mtd2l6EAMyBQgAELEDMgUIABCxAzICCAAyAggAMgIIADICCAAyAggAMgIIADICCAAyAggAOgcIABBHELADOgQIIxAnOgQIABBDOggIABCxAxCDAToICC4QxwEQowI6BwgjEOoCECc6BwgAELEDEEM6CwguELEDEMcBEKMCOgcIABCHAhAUOgcILhCxAxBDOgcILhCHAhAUOgoIABCHAhCxAxAUSgQIQRgAUKCyAVie0QFg-NQBaAJwAngAgAFmiAGBB5IBBDExLjGYAQCgAQGqAQdnd3Mtd2l6sAEKyAEIwAEB&sclient=gws-wiz&ved=0ahUKEwiM67qQ4svxAhWGWc0KHeyhAbcQ4dUDCA0&uact=5
20. https://www.google.com/search?q=DNA+replication&client=firefox-b-1-d&sxsrf=ALeKk01Fu4O8klzXDVGewFWCdnPIRGynMw%3A1625482121278&ei=iePiYOa2EJqUtAb_6oKoBA&oq=DNA+replication&gs_lcp=Cgdnd3Mtd2l6EAMyBwgAELEDEEMyAggAMgQIABBDMgUIABCxAzICCAAyAggAMgIIADICCAAyAggAMgIIADoHCAAQRxCwAzoECCMQJzoFCAAQkQI6DgguELEDEIMBEMcBEKMCOgYIABAKEENKBAhBGABQ29sGWI-AB2DahQdoAXACeACAAWyIAaMKkgEEMTQuMpgBAKABAaoBB2d3cy13aXrIAQjAAQE&sclient=gws-wiz&ved=0ahUKEwimn7Xj4MvxAhUaCs0KHX-1AEUQ4dUDCA0&uact=5
21. https://www.google.com/search?q=DNA+recombination&client=firefox-b-1-d&sxsrf=ALeKk001mNv8X4NK77aJ3L6w309CEheElw%3A1625482237826&ei=_ePiYMvuMc7btAbK077wAg&oq=DNA+recombination&gs_lcp=Cgdnd3Mtd2l6EAMyAggAMgIIADICCAAyAggAMgQIABAKMgIIADICCAAyAggAMgIIADICCAA6BwgAEEcQsAM6BQgAEJECSgQIQRgAUNnEAViv3gFgluMBaAFwAngAgAFziAGLB5IBBDExLjGYAQCgAQGqAQdnd3Mtd2l6yAEIwAEB&sclient=gws-wiz&ved=0ahUKEwiL4f6a4cvxAhXOLc0KHcqpDy4Q4dUDCA0&uact=5
22. https://www.google.com/search?q=DNA+repair&client=firefox-b-1-d&sxsrf=ALeKk01gbAKV3OHyam8TwsWKqXpMG4oVeA%3A1625482268055&ei=HOTiYMfoApbdtAbRkayYDA&oq=DNA+repair&gs_lcp=Cgdnd3Mtd2l6EAMyBQgAELEDMgIIADICCAAyAggAMgIIADICCAAyAggAMgIIADICCC4yAggAOgcIABBHELADOgQIIxAnOgcIABCxAxBDOgoIABCHAhCxAxAUSgQIQRgAUMalAViSrgFgurMBaAFwAngAgAF0iAGlA5IBAzQuMZgBAKABAaoBB2d3cy13aXrIAQjAAQE&sclient=gws-wiz&ved=0ahUKEwjH5rOp4cvxAhWWLs0KHdEIC8MQ4dUDCA0&uact=5
23. https://www.google.com/search?q=chromosome+segregation&client=firefox-b-1-d&sxsrf=ALeKk006HBdo3keQCziQwpWZsiKlCn5ebA%3A1625482292078&ei=NOTiYMmpBIKqtQaoi6CgDQ&oq=chromosome+segregation&gs_lcp=Cgdnd3Mtd2l6EAMyAggAMgIIADICCAAyAggAMgIIADICCAAyAggAMgIIADICCAAyAggAOgcIABBHELADOgQIIxAnOgQIABBDOgUIABCRAjoFCAAQsQM6BwgAELEDEEM6BggAEAoQQ0oECEEYAFC0zwRYwo8FYK-TBWgBcAJ4AIABpwGIAdEOkgEEMjEuMpgBAKABAaoBB2d3cy13aXrIAQjAAQE&sclient=gws-wiz&ved=0ahUKEwjJk-604cvxAhUCVc0KHagFCNQQ4dUDCA0&uact=5
24. https://www.google.com/search?q=chromosome+condensation%2C+heterochromatinization&client=firefox-b-1-d&sxsrf=ALeKk029tG3yAjxUQbghFSThAeEdNrF8Sw%3A1625482377466&ei=ieTiYNLxG_PptQatwLKQCg&oq=chromosome+condensation%2C+heterochromatinization&gs_lcp=Cgdnd3Mtd2l6EAMyBQgAEM0COgcIABBHELADOgcIABCwAxBDOgUIABCRAjoCCAA6BwgAEIcCEBQ6BggAEBYQHjoFCAAQhgM6BggAEA0QHjoHCCEQChCgAToECCEQCkoECEEYAFDgpwFYvooCYLCYAmgBcAJ4AIABgAGIAecXkgEEMzUuMpgBAKABAaoBB2d3cy13aXrIAQrAAQE&sclient=gws-wiz&ved=0ahUKEwiS2snd4cvxAhXzdM0KHS2gDKIQ4dUDCA0&uact=5
25. https://www.google.com/search?q=Recombination+Hotspots&client=firefox-b-1-d&sxsrf=ALeKk03-0RRAbs7osx-4cSgJ1Tcnr1H4_Q%3A1625482414229&ei=ruTiYIe2DYfJtQaKj5HABQ&oq=Recombination+Hotspots&gs_lcp=Cgdnd3Mtd2l6EAMyAggAMgIIADICCAAyBggAEBYQHjIGCAAQFhAeMgYIABAWEB4yBggAEBYQHjIGCAAQFhAeMgYIABAWEB4yBggAEBYQHjoHCAAQRxCwAzoJCCMQJxBGEPkBOgQIIxAnOgUIABCRAjoICC4QsQMQgwE6BAgAEEM6CAguEMcBEKMCOgoIABCxAxCDARBDOgUIABCxAzoICAAQsQMQgwE6BwgAELEDEEM6BwgAEIcCEBQ6CggAEIcCELEDEBQ6AgguSgQIQRgAUMzvAVjYpgJgvqoCaAFwAngAgAFxiAGoDpIBBDIxLjKYAQCgAQGqAQdnd3Mtd2l6yAEIwAEB&sclient=gws-wiz&ved=0ahUKEwiHxY3v4cvxAhWHZM0KHYpHBFgQ4dUDCA0&uact=5
26. https://www.skatelescope.org/outreachandeducation/outreach-resources/amazingfacts/
27. https://www.skatelescope.org/software-and-computing/
28. “Higgs Boson” (Theoretical Half life of 1.6 x 10e-22 sec or 16 yoctosec), and the Large Hadron Collidor.
29. “Computational Power LHC”.
30. “Quantum Computers”

Copyright: © 2021 Ferez Soli Nallaseth., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.