Epstein-Barr Virus and its Capacity to Evade the Immune System to Cause Cancer
Anirban Goutam Mukherjee1, Uddesh Ramesh Wanjari2*, Fereshteh Ramezani3, Aishwarya Laxmi4, Piyush Jagdish Balgote5 and Surbhi Balwant Dhoke2
1Department of Biotechnology, School of Bio-Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India
2Department of Biochemistry, Kamla Nehru Mahavidyalaya, Nagpur, Maharashtra, India
3Student Research Committee, School of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran
4Department of Biotechnology, Institute of science, Banaras Hindu University, Varanasi, Uttar Pradesh, India
5Molecular Biology and Genetic Engineering, RTM Nagpur University, Nagpur, Maharashtra, India
*Corresponding Author: Uddesh Ramesh Wanjari, Department of Biochemistry, Kamla Nehru Mahavidyalaya, Nagpur, Maharashtra, India.
Received: July 10, 2021; Published: August 07, 2021
Epstein-Barr virus (EBV) is a commonly known herpes virus that contains tegument, envelope, DNA, and a core with an icosahedral nucleocapsid. Malignant EBV has been implicated in developing Burkitt's lymphoma, lymphoma, nasopharyngeal cancer, Hodgkin's disease, and non-Hodgkin's lymphoma. Gene rearrangements in the immunoglobulin variable region of lymphoma neoplastic cells indicate their origin B-cells in the germinal center. EBV can infect B-cells at all stages and express growth genes. This review focuses on an in-depth idea of how the virus escapes the immune system to cause cancer. Additionally, this work also sheds light on the association of the EVB in various types of cancers like Burkitt's lymphoma, Non-Hodgkin's Lymphoma, and Leiomyosarcomas.
Keywords: Epstein-Barr Virus (EBV); CD 56; miRNA; CDKs; T-cell
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