Eteme Enama Serge1*, Siama A2, Messi A N3, Mahob R J1 and Njan Nloga A M4
1Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Cameroon
2School of Veterinary Medicine and Sciences, University of Ngaoundéré, Ngaoundéré, Cameroon
3Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaoundé, Cameroon
4Faculty of Science, University of Ngaoundere , Ngaoundéré, Cameroon
*Corresponding Author: Eteme Enama Serge, Faculty of Science, Department of Biological Sciences, University of Yaounde I, Yaounde, Cameroon.
Received: September 17, 2020; Published: December 09, 2020
The SARS-CoV-2 infection rose in December 2019 and afterward spread quickly around the world, especially to China, Japan and South Korea. Researchers are attempting to discover antivirals explicit to the infection. Some drugs Such as arbidol, chloroquine, remdesivir and favipiravir are right as of now experiencing clinical evaluations to test their sensibility and security in the treatment of coronavirus disease 2019 (COVID-19) in China, some consoling results have been developed up until now. This article sums up specialists with expected viability against SARS-CoV-2..
Keywords: Chloroquine; Pneumonia; COVID-19; SARS-CoV-2; Pandemic; Out Break; Antivirals
The objective of this study was to evaluate the trypanocidal effect of the aqueous extract of Ochna schweinfurthiana leaves in vitro and in vivo on trypanosome species: Trypanosoma brucei brucei and Trypanosoma congolense. The search for chemical families by screening and evaluating the trypanocidal effects of the extract in vivo in white mice (50, 100, 200 and 400 mg/kg) and in vitro (0.25; 0.5; 0.75 and 1 mg/kg). Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids and saponins. The doses of the extract of this plant resulted in a decreased motility of the two species of parasites in vitro. For the highest doses (0.5; 0.75 and 1 mg/kg), the decrease is either significant (p < 0.01) or highly significant (p < 0.001). The activity of the extract (400 mg/kg) highly inhibited parasite densities (p < 0.001) compared to the negative control. By against the doses of 100 and 200 mg/kg did not inhibit significantly parasite densities. The results recorded show an improvement in the hematocrit rate in the animals treated at different doses of the extract. This reflects a general decrease in anemia.
Keywords: Trypanosoma brucei brucei; Trypanosoma congolense; Ochna schweinfurthiana Leaves; Trypanocidal Effect
Citation: Eteme Enama Serge., et al. “Trypanocidal Effect of the Aqueous Extract of the Leaves of Ochna schweinfurthiana In Vitro and In Vivo on White Mice Mus musculus Swiss". Acta Scientific Microbiology 4.1 (2021): 47-51.
Copyright: © 2021 Eteme Enama Serge., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.