Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Research Article Volume 3 Issue 11

The Influence of the Microorganisms Supernatants of Bacteroides fragilis, Bacteroides melaninogenicus, Escherichia coli were Kept in Nutrient-Free Saline on the Mice Body Weight

Pavel F Zabrodskii1* and Anatoly A Animitsa2

1Saratov Medical University "REAVIZ", Saratov, Russia
2Independent Researcher, Mariupol, Ukraine

*Corresponding Author: Pavel F Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russia.

Received: August 19, 2020; Published: October 28, 2020

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Abstract

  There is a close relationship between the intestinal microbiota and the central nervous system, based on the efferent innervation of the gastrointestinal tract and the biochemical signals of neuroactive microbiota molecules. The microbiome-gut-brain axis includes the intestinal microbiota, the central nervous system, the neuroendocrine and neuroimmune systems, including the hypothalamic-pituitary-adrenal system, the sympathetic and parasympathetic parts of the autonomic nervous system, and the enteral nervous system. It is revealed that the microbiota of the mice intestinal affects the regulation of animal body weight. Supernatant of three main types of intestinal microorganisms (Bacteroides fragilis, Bacteroides melaninogenicus, Escherichia coli), which were for two days in saline without nutrients (1.0 × 109 CFUs in 1.0 ml of saline), significantly (by 10.2%) increased the weight of mice after daily intragastric administration (0.7 ml) for 30 days. The data obtained suggest that microorganisms of the intestines of animals produce neuroactive substances that can both increase and, apparently, reduce their body weight.

Keywords: Microbiome-Gut-Brain Axis; Neuroactive Molecules from Intestinal Microorganisms; Bacteroides fragilis; Bacteroides melaninogenicus; Escherichia coli; Mice Body Weight

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Citation

Citation: Pavel F Zabrodskii and Anatoly A Animitsa. “The Influence of the Microorganisms Supernatants of Bacteroides fragilis, Bacteroides melaninogenicus, Escherichia coli were Kept in Nutrient-Free Saline on the Mice Body Weight". Acta Scientific Microbiology 3.11 (2020): 84-86.




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Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.172

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