Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Research Article Volume 3 Issue 10

The Role of Xenobiotic Enzyme Genes of the First and Second Phases in the Pathogenesis of Fetal Growth Restriction Syndrome

Mavlyanova NN*

Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Under the Ministry of Health of the Republic of Uzbekistan, Uzbekistan

*Corresponding Author: Mavlyanova NN, Republican Specialized Scientific and Practical Medical Center of Obstetrics and Gynecology Under the Ministry of Health of the Republic of Uzbekistan, Uzbekistan.

Received: June 16, 2020; Published: September 30, 2020



  The article presents the results of molecular genetic studies of genes of biotransformation enzymes of xenobiotics of the first and second phase in pregnant women with fetal growth restriction syndrome. Using the del/del genotype variants of the GSTM1 and GSTT1 genes and G alleles of the GSTP1 gene, one can determine the prognosis of the risk of developing fetal loss syndrome, characterized by impaired detoxification during pregnancy.

Keywords: GSTM1; GSTT1; Fetal Growth Restriction Syndrome (FGRS)



  1. NA Davydova., et al. “Analysis of polymorphic variants of the T1, M1 and P1 glutathione S-transferase genes in patients with prostate cancer”. XI Russian Oncological Congress: Congressional materials (2007): 224.
  2. Ahmed-zade VA. “Pregnancy and childbirth with antiphospholipid syndrome: course, perinatal outcomes”. Medical News 5 (2011): 81-85.
  3. Barinova IV. “Pathogenesis of antenatal death: phenotypes of fetal loss and thanatogenesis”. Russian Bulletin of the Obstetrician-Gynecologist 1 (2015): 68-76.
  4. Bespalova ON. “Genetics of miscarriage”. Journal of Obstetrics and Women's Diseases (2007): 81-95.
  5. Gavalov SM., et al. “The association of gene polymorphism of xenobiotic biotransformation and detoxification enzymes with children with bronchial asthma features”. Allergology 3 (2000): 14-21.
  6. Guzov II. “Plasmogen activator inhibitor gene polymorphism - 1 (PAI-1) - risk of developing obstetric pathology”.
  7. Eliseeva Yu E. “Angiotensin-converting enzyme, its physiological role”. Questions of Medical Chemistry 1 (2001): 15-21.
  8. Lyubchich NI and Boboev KT. “Study of the role of coagulation system gene polymorphism in the occurrence of preterm birth in women of the Uzbek population”. Medical Genetics14 (2015): 37-41.
  9. Makatsaria AD. “Antiphospholipid syndrome - immune thrombophilia in obstetrics and gynecology”. (2007): 55-112.
  10. Melkozerova OA., et al. “Molecular genetic predictors of abnormal uterine bleeding in girls born with intrauterine growth retardation syndrome”. Obstetrics and Gynecology 11 (2016): 95-100.
  11. Morozova KV and Lutsenko NN. “The role of gene polymorphism of antioxidant system enzymes in the genesis of miscarriage”. Obstetrics, Gynecology and Reproduction 2 (2015): 54-61.
  12. Tyszkiewicz OB. Features of the hemostatic system in women with habitual miscarriage and the presence of antiphospholipid antibodies in the blood plasma: author. dis. ... cand. medical science. - SPb (2004): 24.
  13. Fedorova IA., et al. “Molecular genetic aspects of metanephrogenesis in norm and pathology: scientific publication”. Russian Bulletin of Perinatology and Pediatrics5 (2012): 45-51.
  14. Khodzhaeva DA., et al. “The role of SOD2 gene polymorphism in women in the genesis of non-developing pregnancy”. Bulletin of the Russian State Medical University 2 (2011): 134-136.
  15. Amirchaghmaghi E., et al. “Gene expression analysis of VEGF and its receptors and assessment of its serum level in unexplained recurrent spontaneous abortion”. Cell Journal16 (2016): 538-545.
  16. Liu SY., et al. “Association between single nucleotide polymorphisms of 5’-untranslated region of GPx4 gene and male infertility”. 28.3 (2011): 270-274.
  17. Bermano G., et al. “Evidence that a polymorphism within the 3’UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. School of Life Sciences, The Robert Gordon University, Aberdeen, AB25 1HG, UK”. Genes Nutrition2 (2007): 225-232.
  18. Lin JC., et al. “Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer”. Surgery 5 (2009): 508-513.
  19. Mlakar SJ., et al. “Antioxidant enzymes GSR, SOD1, SOD2, and CAT gene variants and bone mineral density values in postmenopausal women: a genetic association analysis”. Menopause 3 (2012): 368-376.
  20. Quick SK., et al. “Effect modification by catalase genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk”. Cancer Epidemiology, Biomarkers and Prevention 5 (2008): 1082-1087.
  21. Seamus J Murphy., et al. “A population - based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett, s esophagus and esophageal adenocarcinoma”. Carcinogenesis 6 (2007): 1323-1328.
  22. Yang H., et al. “The association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population: evidence from an updated meta-analysis”. Science Report 5 (2015): 9392.


Citation: Mavlyanova NN. “The Role of Xenobiotic Enzyme Genes of the First and Second Phases in the Pathogenesis of Fetal Growth Restriction Syndrome". Acta Scientific Microbiology 3.10 (2020): 84-89.


Acceptance rate30%
Acceptance to publication20-30 days

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