Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Mini Review Volume 3 Issue 10

An Insight into the Coronavirus

Priyanka Kulkarni and Jayant Londhe*

Department of Biotechnology, Sinhgad College of Science, Ambegaon, Pune, India

*Corresponding Author: Jayant Londhe, Assistant Professor, Department of Biotechnology, Sinhgad College of Science, Ambegaon, Pune, India.

Received: August 08, 2020; Published: September 24, 2020



  The Coronavirus outbreak has brought the Science fraternity to put some light on the history and evolution of the virus and also the design of the effective drug and its potential target. Coronavirus consists of a positive strand RNA genome and four characteristic structural proteins, active and viable below 560C. Surprisingly, all the strains of Coronaviruses are found to be residing in bats for long period of time along with the Malayan pangolins, a group of mammals. The SARS-CoV-2 has significant similarities with SARS-CoV and SARsSr- RaTGL3 in the sequences of conserved non-structural proteins and exhibit 96.2% genome similarity with SARsSr- RaTGL3 virus. However, a unique feature of SARS-CoV2 is the presence of the four amino acid residue sequence at S1/S2 junction which is required to be cleaved by Furin-like enzymes for efficient membrane fusion of host and the virus. This distinguishing feature gives a reason to become a promising factor for drug target studies. However, the infectious diseases could be effectively controlled by vaccine. Hence, there are some promising candidate vaccines entered into Phase III of Clinical trials designed by Sinovac, Moderna Inc and AstraZeneca/Oxford University in collaboration with Serum Institute of India.

Keywords: Coronavirus; SARS-CoV2; SARsSr- RaTGL3; Spike Proteins; Drug Target; Vaccine



  1. , et al. “Bats and Coronaviruses”. Viruses 11.1 (2019): 1-15.
  2. in “Coronavirus update: 7 Indian firms in race to find COVID-19 vaccine”. Business Today (2020).
  3. Cavanagh D. “Coronaviridae: a review of coronaviruses and toroviruses’’. Coronaviruses with Special Emphasis on First Insights Concerning SARS, edited by A. Schmidt, M.H. Wolff and O. Weber (2005): 1-55.
  4. Chan K., et al. “The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus”. Advances in Virology (2011): 7.
  5. Cui J., et al. “Origin and evolution of pathogenic coronaviruses”. Nature Reviews Microbiology 17 (2019): 181-192.
  6. DRAFT Landscape of COVID-19 Candidate Vaccines. World Health Organization (2020).
  7. Fehr A and Perlman S. “Coronaviruses: An Overview of Their Replication and Pathogenesis”. Coronaviruses: Methods and Protocols Methods in Molecular Biology, edited by Helena Maier, Erica Bickerton Paul Britton (2015): 1-23.
  8. Hiscox J., et al. “The Coronavirus Infectious Bronchitis Virus Nucleoprotein Localizes to the Nucleolus”. Journal of Virology1 (2000): 506-512.
  9. Jaimes J., et al. “Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of Novel S1/S2 Site”. Science6 (2020): 101212.
  10. Lam T., et al. “Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins”. Nature 583 (2020): 282-285.
  11. Li F. “Structure, Function, and Evolution of Coronavirus Spike Proteins”. Annual Reviews of Virology 3 (2016): 237-261.
  12. Padron- Regalado E. “Vaccines for SARS-CoV-2: Lessons from Other Coronavirus Strains”. Infectious Diseases and Therapy 9 (2020): 255-274.
  13. Sidell S., et al. “Coronaviridae”. Intervirology 20 (1983): 181-189.
  14. Tang X., et al. “Prevalence and Genetic Diversity of Coronaviruses in Bats from China”. Journal of Virology 15 (2006): 7481-7490.
  15. Weiss S and Navas-Martin S. “Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus”. Microbiology and molecular Biology Reviews4 (2005): 635-644.
  16. Zhang J., et al. “Progress and Prospects on Vaccine Development against SARS-CoV-2”. Vaccines 2 (2020): 1-12.
  17. Zhou P., et al. “A pneumonia outbreak associated with a new coronavirus of probable bat origin”. Nature 579 (2020): 270-273.


Citation: Priyanka Kulkarni and Jayant Londhe. “An Insight into the Coronavirus". Acta Scientific Microbiology 3.10 (2020): 70-74.


Acceptance rate30%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US