Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Research Article Volume 3 Issue 10

Making MIC Work for You: Utilizing PK and PD Parameters

Dharmendra Sharma1 and Ashok Rattan2*

1Associate Professor, Department of Basic Medical Sciences, College of Medicine at Shaqra, Shaqra University, Kingdom of Saudi Arabia
2Adviser, Laboratory Operations, Pathkind Labs, Pathkind Diagnostics Pvt Ltd., Gurgaon, Haryana, India

*Corresponding Author: Ashok Rattan, Adviser, Laboratory Operations, Pathkind Labs, Pathkind Diagnostics Pvt Ltd., Gurgaon, Haryana, India.

Received: July 20, 2020; Published: September 16, 2020

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Abstract

  MIC or MBC has been used as indicator of antibiotic potency towards a pathogen and as surrogate marker for clinical efficacy when the selected antibiotic is used in the patient, but these parameters are static measures and do not adequately reflect the dynamic process that takes place in a patient. To better predict the clinical efficacy of the drug we need to take into consideration the pharmacokinetics (what the host does to the drug) and the pharmacokinetics (what the drug does to the bug) and to obtain the three PK/PD parameters each of which depends upon the MIC value obtained but better predictive the clinical efficacy of the selected antibiotic.

Keywords: Minimum Inhibitory Concentration (MIC); Minimum Bactericidal Concentration (MBC); PK and PD Parameters

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Citation

Citation: Dharmendra Sharma and Ashok Rattan., et al. “Making MIC Work for You: Utilizing PK and PD Parameters". Acta Scientific Microbiology 3.10 (2020): 16-21.



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