Abstract

  MIC or MBC has been used as indicator of antibiotic potency towards a pathogen and as surrogate marker for clinical efficacy when the selected antibiotic is used in the patient, but these parameters are static measures and do not adequately reflect the dynamic process that takes place in a patient. To better predict the clinical efficacy of the drug we need to take into consideration the pharmacokinetics (what the host does to the drug) and the pharmacokinetics (what the drug does to the bug) and to obtain the three PK/PD parameters each of which depends upon the MIC value obtained but better predictive the clinical efficacy of the selected antibiotic.

Keywords: Minimum Inhibitory Concentration (MIC); Minimum Bactericidal Concentration (MBC); PK and PD Parameters

References

1. Shah PM., et al. “Bactericidal dosie-activity relationships with coli, K. pneumoniae and Staph. aureus (author's transl)”. Deutsche Medizinische Wochenschrift 101 (1976): 325-328.
2. Craig WA. “Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men”. Clinical Infectious Diseases 1 (1998): 1-12.
3. Drusano GL. “Pharmacokinetics and pharmacodynamics of antimicrobials”. Clinical Infectious Diseases 45 (2007): S89-S95.
4. Jambhekar SS and Breen PJ. “Basic Pharmacokinetics: 2^nd edition”. (Pharmaceutical press, London, UK) (2012): 55-77.

Citation

Citation: Dharmendra Sharma and Ashok Rattan., et al. “Making MIC Work for You: Utilizing PK and PD Parameters". Acta Scientific Microbiology 3.10 (2020): 16-21.

Copyright

Copyright: © 2020 Dharmendra Sharma and Ashok Rattan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.