Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Review Article Volume 3 Issue 9

Bioactivity of Endophytes from the Brazilian Tropical Savannah

Andréa Cristina Bogas1,2*, Flavia Luana Torres2, Cristina Paiva de Sousa1,2 and Paulo Teixeira Lacava1,2

1Department of Morphology and Pathology, Center for Biological and Health Sciences, Federal University of São Carlos, Brazil
2Post-graduation Program of Biotechnology, Federal University of São Carlos, Brazil

*Corresponding Author: Andréa Cristina Bogas, Department of Morphology and Pathology, Center for Biological and Health Sciences, Federal University of São Carlos, Brazil.

Received: July 01, 2020; Published: August 18, 2020



The Brazilian tropical savannah is a mosaic biome, the second largest in the Brazilian territory and the most biodiverse tropical savannah in the world. Endophytes and host plants have a symbiotic relationship, in which both are beneficial. The host plant provides protection to the endophytes, which, in turn, increase the fitness of the plant by inducing resistance to pathogens due to niche competition andor synthesizing antibiotics, lytic enzymes and siderophores. Although initial studies on endophytes were directed to those living in symbiosis with temperate plants, in recent years, many reports describing the isolation of endophytic bacteria and fungi from tropical plants have been published. Secondary metabolites produced by endophytes are a promising source of bioactivity. The biochemical versatility and diversity of these microorganisms suggest that there are many unknown active compounds. Another important goal is the agronomic potential of endophytic fungi from tropical savannah. Bioprospecting studies have reported the potential of endophytes against a large number of phytopathogens responsible for large losses in economically important tropical crops. Thus far, the main method for controlling plant diseases is the application of chemicals. Nevertheless, chemicals cause toxic effects to humans, animals and the environment. Therefore, endophytic microorganisms have been considered an alternative for the control of phytopathogens and consequent augmented crop production. The lack of studies related to endophytes isolated from tropical environments enhances their importance. This review focuses on the potential activities produced by endophytes isolated from medicinal plants and their industrial, pharmaceutical and agronomic applications.

Keywords: Endophytic Microorganisms; Cerrado; Bioactive Compounds; Antimicrobial; Biocontrol; Plant Growth Promotion



  1. Batalha MA. “O cerrado não é um bioma”. Biota Neotropica1 (2011): 21-24.
  2. Ratter JA., et al. “The Brazilian Cerrado vegetation and threats to its biodiversity”. Annals of Botany 3 (1997): 223-230.
  3. Mendonça RC., et al. “Flora vascular do cerrado”. In: Sano SM, Almeida SP (eds) Cerrado: ambiente e flora. Embrapa- CPAC (1998): 287-556.
  4. Myers N., et al. “Biodiversity hotspots for conservation priorities”. Nature 403 (2000): 853-858.
  5. Adamoli J., et al. “Caracterização da região dos Cerrados”. In: Goedert WJ (ed) Solos dos Cerrados: Tecnologias e Estratégias de Manejo. Embrapa and Nobel Press, São Paulo (1985): 33-74.
  6. Hallmann J., et al. “Bacterial endophytes in agricultural crops”. Canadian Journal of Microbiology10 (1997): 895-914.
  7. Schulz B and Boyle C. “Microbial root endophytes”. In: Sieber TN (ed) What are endophytes?. Springer, Berlin (2006): 1-13.
  8. Strobel G. “The emergence of endophytic microbes and their biological promise”. Journal of Fungi2 (2018): 57.
  9. Zheng Y., et al. “Diversity, distribution and biotechnological potential of endophytic fungi”. Annals of Microbiology 66 (2016): 529-542.
  10. Bibi SN., et al. “Fungal endophytes associated with mangroves Chemistry and biopharmaceutical potential”. South Africa Journal of Botany (2020).
  11. Marques NP., et al. “Cellulases and xylanases production by endophytic fungi by solid state fermentation using lignocellulosic substrates and enzymatic saccharification of pretreated sugarcane bagasse”. Industrial Crops and Products 122 (2018): 66-75.
  12. Yan L., et al. “Production of bioproducts by endophytic fungi: chemical ecology, biotechnological applications, bottlenecks, and solutions”. Applied Microbiology and Biotechnology 102 (2018): 6279-6298.
  13. Almeida SP., et al. “Cerrado espécies vegetais úteis”. Embrapa, Planaltina, DF (1998): 464.
  14. Pavan FR., et al. “In vitro anti- Mycobacterium tuberculosis activity of some Brazilian “Cerrado” plants”. Revista Brasileira de Farmacognosia 19 (2009): 204-206.
  15. Favoretto NB. “Produção de substâncias bioativas por microrganismos endofiticos isolados do cerrado de São Carlos”. Dissertation, Universidade Federal de São Carlos, Brazil (2010).
  16. Serrano NFG., et al. “Optimal glucose and inoculum concentrations for production of bioactive molecules by Paenibacillus polymyxa RNC-D”. Chemical Papers12 (2012): 1111-1117.
  17. Piza ACMT., et al. “Endophytic actinomycetes from Miconia albicans (Sw.) Triana (Melastomataceae) and evaluation of its antimicrobial activity”. Journal of Scientific Research and Reports4 (2015): 281-291.
  18. Neris DM., et al. “Cytotoxic effects and production of cytokines induced by the endophytic Paenibacillus polymyxa RNC-D in vitro”. Current Pharmaceutical Biotechnoogy9 (2017): 758-768.
  19. Vaz ABM., et al. “Diversity and antimicrobial activity of fungal endophyte communities associated with plants of Brazilian savanna ecosystems”. African Journal of Microbiology Research 6 (2012): 3173-3185.
  20. Furlanetto C and Dianese JC. “Some coelomycetes from Central Brazil”. Mycology Research1 (1998): 19-29.
  21. Rampelotto PH., et al. “Changes in diversity, abundance, and structure of soil bacterial communities in Brazilian Savanna under different land use systems”. Microbiology Ecology 66 (2013): 593-607.
  22. Felfili JM and Fagg CW. “Floristic composition, diversity and structure of the “Cerrado” sensu stricto on rocky soils in northern Goiás and southern Tocantins, Brazil”. Revista Brasileira de Botânica 30 (2007): 375-385.
  23. Pausas JG. “Homage to LM Coutinho: fire adaptations in Cerrado plants”. International Journal of Wildland Fire3 (2017): 249-251.
  24. Pinheiro ES and Durigan G. “Diferenças florísticas e estruturais entre fitofisionomias do Cerrado em Assis, SP, Brasil”. Revista Arvore1 (2012): 181-193.
  25. Ratti RP., et al. “Antagonistic properties of some microorganisms isolated from Brazilian tropical savannah plants against Staphylococcus coagulase-positive strain”. Journal of Venomous Animals and Toxins including Tropical Diseases2 (2008): 294-302.
  26. Suryanarayanan TS., et al. “Fungal endophytes and bioprospecting”. Fungal Biology Reviews1-2 (2009): 9-19.
  27. Debbab A. et al. “Bioactive secondary metabolites from endophytes and associated marine derived fungi”. Fungal Diversity1 (2011): 1-12.
  28. Strobel G.A., et al. “Natural products from 6 endophytic microorganisms”. Journal of Natural Products2 (2004): 257-268.
  29. Gunatilaka AAL. “Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity and implications of their occurrence”. Journal Natural Product3 (2006): 509-526.
  30. Bos J and Austin RH. “A bacterial antibiotic resistance accelerator and applications”. Methods in Cell Biology 147 (2018): 41-57.
  31. Allen HK., et al. “Call of the wild: antibiotic resistance genes in natural environments”. Nature Reviews Microbiology 8 (2010): 251-259.
  32. Owen NL and Hundley N. “Endophytes the chemical synthesizer inside plants”. Science Progress 87 (2004): 79-99.
  33. Huang B., et al. “Heterologous production of secondary metabolites as pharmaceuticals in Saccharomyces cerevisiae”. Biotechnology Letters 30 (2008): 1121-1137.
  34. Assis PCP. “Bactérias endofíticas isoladas de Caryocar brasiliense: atividade enzimática, antimicrobiana, leishmanicida e cocultura com microrganismos patogênicos”. MS Thesis, Universidade Federal de São Carlos, Brazil (2018).
  35. Araújo FD. “A review of Caryocar brasiliense (Caryocaraceae): an economically valuable of central Brazilian Cerrados”. Economic Botany 49 (1995): 40-48.
  36. Paula-Junior W., et al. “Leishmanicidal, antibacterial, and antioxidant activities of Caryocar brasiliensis leaves hydroethanolic extract”. Revista Brasileira de Farmacognosia 16 (2006): 625-630.
  37. Ruela AC. “Microbioma de Bacillus pumilus, endofítico associado à Tabebuia rosea alba do Cerrado e importância para a saúde: bioatividade e metabolômica”. Dissertation, Universidade Federal de São Carlos, Brazil (2018).
  38. Lal S and Tabacchioni S. “Ecology and biotechnological potential of Paenibacillus polymyxa: A mini review”. Indian Journal of Microbiology 49 (2009): 2-10.
  39. Liang TW and Wang SL. “Recent advances in exopolysaccharides from Paenibacillus : Production, isolation, structure, and bioactivities”. Marine Drugs 13.4 (2015): 1847-1863.
  40. Lorenzi H. “Árvores brasileiras: manual de identificação e cultivo de plantas arbóreas nativas do Brasil”. 2. ed. Plantarum, Nova Odessa (1998).
  41. Lima JCS., et al. “Experimental evaluation of stem bark of Stryphnodendron adstringens (Mart.) Coville for anti-inflammatory activity”. Phytotherapy Research 12 (1998): 218-220.
  42. Felipe AMM., et al. “Antiviral effect of Guazuma ulmifolia and Stryphnodendron adstringens on poliovirus and bovine herpesvirus”. Biological & Pharmaceutical Bulletin6 (2006): 1092-1095.
  43. Almeida AC., et al. “Acute and chronic toxicity and antimicrobial activity of the extract of Stryphnodendron adstringens (Mart.) Coville”. Pesquisa Veterinária Brasileira8 (2017): 840-846.
  44. Moura TM., et al. “Correlação entre floração, frutificação e variáveis ambientais em Solanum lycocarpum. St. Hil, Solanaceae”. Bioscience Journal 26 (2010): 457-462.
  45. Oliveira Junior EM., et al. “Alterações pós-colheita da "fruta-de-lobo" (Solanum lycocarpum Hil.) durante o amadurecimento: análises físico-químicas, químicas e enzimáticas”. Revista Brasileira de Fruticultura 26.3 (2004): 410-413.
  46. Elias SEM., et al. “Leaf anatomy in young plants of Solanum lycocarpum St-Hill. (Solanaceae)”. Revista Brasileira de Botânica 26 (2003): 169-174.
  47. Costa GAF., et al. “Antioxidant, antibacterial, cytotoxic, and anti-inflammatory potential of the leaves of Solanum lycocarpum St. Hil. (Solanaceae)”. Evidence-Based Complementary and Alternative Medicine (2015).
  48. Perez AC., et al. “Effect of Solanum lycocarpum Hill on various haematological parameters in diabetic rats”. Journal of Ethnopharmacology 106.3 (2006): 442-444.
  49. Torres FL. “Isolamento, caracterização e potencial biotecnológico de fungos endofíticos associados às plantas de Cerrado”. Dissertation, Universidade Federal de São Carlos, Brazil (2018).
  50. Noriler AS., et al. “Bioprospecting and structure of fungal endophyte communities found in the Brazilian biomes, Pantanal, and Cerrado”. Frontiers in Microbiology 9 (2018).
  51. Faria PSA., et al. “Assessment of functional traits in the assemblage of endophytic fungi of Anacardium othonianum Rizzini”. Pakistan Journal of Botany3 (2016): 1241-1252.


Citation: Andréa Cristina Bogas., et al. “Bioactivity of Endophytes from the Brazilian Tropical Savannah". Acta Scientific Microbiology 3.9 (2020): 15-22.

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