Abstract

Paracetamol is the most commonly used mild analgesic. It is easily accessible and is widely used worldwide to treat common ailments like pain and fever. Previous studies have shed light on the hepatotoxicity associated with Paracetamol overdose and hinted at its ties to the enzyme Cyclooxygenase which it inhibits to alleviate Prostaglandin synthesis and hence pain. However, little research has been done on its pharmacokinetics and pharmacomicrobiomics. The exact mechanism of action of Paracetamol still remains a mystery and little is known about its effect on the gut flora, if any. In this paper, we briefly assess the antimicrobial activity of Paracetamol.

Keywords: Acetaminophen; Antimicrobial; Analgesic; Crocin; Cyclooxygenase; Escherichia coli; Staphylococcus aureus; Paracetamol; Prostaglandins

References

1. Madigan M and Martinko J (editors). Brock Biology of Microorganisms (11^th edition). Pearson Prentice Hall (2006).
2. Gibbons NE and Murray RGE. "Proposals Concerning the Higher Taxa of Bacteria". International Journal of Systematic and Evaluation Microbiology1 (1978).
3. Woese CR. "Bacterial evolution". Microbiological Reviews (1987).
4. "Protein phylogenies and signature sequences: A reappraisal of evolutionary relationships among archaebacteria, eubacteria and eukaryotes". Microbiology and Molecular Biology Reviews 62.4 (1998): 1435-1491.
5. Gupta RS. "The natural evolutionary relationships among prokaryotes". Critical Reviews in Microbiology 26 (2000): 111-131.
6. Desvaux M., et al. "Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue". Trends in Microbiology 17 (2009): 139-145.
7. Sutcliffe IC. "A phylum level perspective on bacterial cell envelope architecture". Trends in Microbiology10 (2010): 464-470.
8. Gupta RS. "What are archaebacteria: life's third domain or monoderm prokaryotes related to gram-positive bacteria? A new proposal for the classification of prokaryotic organisms". Molecular Microbiology (1998).
9. Gupta RS. "Origin of diderm (gram-negative) bacteria: antibiotic selection pressure rather than endosymbiosis likely led to the evolution of bacterial cells with two membranes". Antonie van Leeuwenhoek (2011).
10. Baron S, Salton MR, Kim KS. "Structure". In Baron S, et al. Baron's Medical Microbiology (4^th edition). Univ of Texas Medical Branch (1996).
11. Woese CR. "Bacterial evolution". Microbiology Review (1987).
12. Madigan M and Martinko J. Brock Biology of Microorganisms (11^th edition) (2005).
13. Kumar A and Schweizer HP. “Bacterial Resistance to Antibiotics: Active Efflux and Reduced Uptake”. Advanced Drug Delivery Reviews (2005).
14. Lambert PA. “Bacterial resistance to Antibiotics: Modified Target Sites”. Advanced Drug Delivery Reviews 10 (2005): 1486-1513.
15. Levy SB. “The Antibiotic Paradox, 2^nd edition”. Perseus Publishing, USA (2002).
16. Martinez JL and Baquero F. “Mutation frequencies and antibiotic resistance”. Antimicrobial Agents and Chemotherapy (2000).
17. Nordmann P and Poirel L. “Emergence of Plasmid-Mediated Resistance to Quinolones in Enterobacteriaceae”. Journal of Antimicrobial Chemotherapy3 (2005): 463-469.
18. Poole K. “Efflux-mediated Antimicrobial Resistance”. Journal of Antimicrobial Chemotherapy 56 (2005): 20-51.
19. Roe MT and Pillai SD. “Monitoring and Identifying Antibiotic resistance Mechanisms in Bacteria”. Poultry Science 4 (2003): 622-666.
20. Rouveix B. “Clinical implications of multiple drug resistance efflux pumps of pathogenic bacteria”. Journal of Antimicrobial Chemotherapy 6 (2007): 1208-1209.
21. Sköld O. “Sulfonamide Resistance: Mechanisms and Trends”. Drug Resistance Updates 3 (2000): 155-160.
22. Turnidge J and Peterson DL. “Setting and Revising Antibacterial Susceptibility Breakpoints”. Clinical Microbiology Reviews 3 (2007): 391–408.
23. Walsh C. “Molecular Mechanisms that Confer Antibacterial Drug Resistance”. Nature 406.6797 (2000): 775-781.
24. Watts JL and Lindeman CJ. Chapter 3: Antimicrobial Susceptibility Testing of Bacteria of Veterinary Origin. Antimicrobial Resistance in Bacteria of Animal Origin, FM Aarestrup, ed. ASM Press, Washington DC, USA (2006).
25. White DG., et al. Chapter 5: Antimicrobial Susceptibility Testing Methodologies. Microbial food Safety in Animal Agriculture Current Topics. ME Torrence and RE Isaacson, eds. Iowa State Press, Iowa, USA (2003).
26. Witte W. “Selective Pressure by Antibiotic Use in Livestock”. International Journal of Antimicrobial Agents 16 (2000): S19-24.
27. Althaf Abdul S., et al. “Formulation and evaluation of oral fast dissolving tablets of Sildenafil Citrate”. International Journal of Pharmacy and Pharmaceutical Sciences 3 (2011).
28. P Ashish., et al. “Formulation of mouth dissolving tablet”. International Journal of Pharmaceutical and Clinical Science (2011).
29. Srivastava Saurabh., et al. “Mouth dissolving tablets”. International Research Journal of Pharmacy (2012).
30. Momin Munira., et al. “Taste masking techniques for bitter drugs”. International Journal of Pharmacy and Technology 4 (2012): 2100-2118.
31. Chawla Gagandeep and Jain Nitin. “Mouth dissolving tablets”. International Journal of Pharmaceutical Sciences and Research 3 (2012).
32. Parashar Bharat., et al. “Fast dissolving tablet”. International Journal of Applied Pharmaceutics 4 (2012): 17-22.
33. Beedi Neena., et al. “Development and Evaluation of Paracetamol taste masked orally disintegrating tablets using polymer coating techniques”. International Journal of Pharmaceutical Sciences 4 (2012): 129-134.
34. AA Mohsin., et al. “Formulation and Evaluation of mouth dissolving tablets of Amitriptyline hydrochloride by direct compression technique”. International Journal of Pharmaceutical Sciences 2 (2010).
35. Nikam K Vikrant., et al. “Mouth dissolving tablets”. Pharmacologyonline 3 (2011): 562-586.
36. Deshmukh ND., et al. “Formulation and Evaluation of Bisoprololfumarate fast dissolving tablet by direct compression techniques”. International Journal of Pharma and Bio Sciences 1 (2012).
37. Fatima Nudrat., et al. “Studies on effects of cyclodextrin polymer as tableting aid on some selected analgesics”. Pakistan Journal of Pharmacology 23 (2006).
38. Ch Praveen Kumar., et al. “Formulation and Evaluation of Diazepam mouth dissolving tablets”. Indian Journal of Pure and Applied Physics1 (2011): 356-361.
39. Mahajan AB., et al. Formulation of dispersible paediatric tablets of chloroquine phosphate using resins. 49th Indian pharmaceutical congress, scientific abstracts (1997).
40. Microbiology, Jacquelyn Black, Prentice Hall (1993).
41. J Buie. "Evolution of Biological Shakers and Stirrers” (2011).

Citation

Citation: Ayushi Goel., et al. “To Assess the Antimicrobial Action of Paracetamol". Acta Scientific Microbiology 3.8 (2020): 65-70.

Copyright

Copyright: © 2020 Ayushi Goel., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.