Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Short Communication Volume 3 Issue 7

Cytokine Storming in COVID-19

Attapon Cheepsattayakorn1* and Ruangrong Cheepsattayakorn2*

110th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand
2Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.

Received: April 25, 2020; Published: June 16, 2020

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  During viral infection, cytokines play an important role in immunopathology with the first line of defense against viral infection via rapid and well-coordinated innate immune response. In vitro studies reveal that delayed release of cytokines and chemokines occurs in respiratory epithelial cells, macrophages and dendritic cells (DCs) at the early stage of severe-acute-respiratory-syndrome coronavirus (SARS-CoV) infection, including COVID-19 infection. At the later stage of infection, these cells secrete low levels of the antiviral factors-interferons (IFNs) and high levels of proinflammatory cytokines (interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) and chemokines (C-C motif chemokine ligand (CCL-2, CCL-3 and CCL-5.

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References

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Citation

Citation: Attapon Cheepsattayakorn and Ruangrong Cheepsattayakorn. “Cytokine Storming in COVID-19". Acta Scientific Microbiology 3.7 (2020): 27.



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