Acta Scientific Microbiology (ASMI) (ISSN: 2581-3226)

Research Article Volume 3 Issue 6

Effects of Bacteriophage Therapy on Host Immune Responses in Brucellosis Affected Cattle

Anju Mohan and Hari Mohan Saxena*

Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India 141001.

*Corresponding Author: Hari Mohan Saxena, Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.

Received: April 10, 2020; Published: May 28, 2020

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Abstract

 We studied the effect of phage therapy on immune responses in Brucellosis affected cattle. There was a very significant (p<0.01) increase in total serum proteins from 0D to 45D, 60D and 75D and from 30D to 45D and a decrease from 45D to 90D, respectively. There was a significant (p<0.05) increase in total serum proteins from 0D to 30D and 90D and a decrease from 45D to 75D. Serum globulin level increased very significantly (p<0.01) from 0D to 45D and 60D. The increase in serum globulin level from 30D to 45D and decrease from 45D to 90D were significant (p<0.05). There was a very significant (p<0.01) rise in anti-Brucella antibody titers estimated by Standard Tube Agglutination Test (STAT titers) from 0D to 45D and 60D along with a significant (p<0.05) decline from 45D to 90D. There was a very significant (p<0.01) rise in MAT titers from 0D to 45D and 60D along with a decline from 45D to 90D. The rise in titer from 30D to 45D was significant (p<0.05). There was a very significant (p<0.01) rise in IHA titers from 0D to 45D and 60D and a significant (p<0.05) rise from 0D to 75D. There was a very significant (p<0.01) decline in ELISA titers from 30D to 60D, 75D and 90D, respectively. The decline in titers from 0D to 60D and 75D and from 45D to 60D and 75D was significant (p<0.05). There was a very significant (p<0.01) decrease in the levels of lymphocytes from 0D to 30D followed by increase from 30D to 45D, 60D and 75D. The increase from 30D to 90D was very significant (p<0.01). However, Levels of leukocytes, monocytes and neutrophils did not differ significantly among themselves during the period of 90 days after treatment with the phage.This suggests that phage therapy in Brucellosis stimulates immune responses in cattle initially which decline slowly after 45 days.

Keywords: Phage Therapy; Brucellosis;_Antibody Titers; Leukocytes; Lymphocytes; Neutrophils

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Citation

Citation: Anju Mohan and Hari Mohan Saxena. “Effects of Bacteriophage Therapy on Host Immune Responses in Brucellosis Affected Cattle". Acta Scientific Microbiology 3.6 (2020): 146-151.



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