Abstract

  The most important and primary factor that is responsible for infectivity in any viral disease is the entry of viral nucleocapsid into the host cell. The viral capsid will attach only on specific sites on the cell membrane depending upon the chemotaxic nature. This article deals with some of the mechanisms of attachment of capsid on the host cell membranes. However, attachment of oncogenic viruses will not be discussed. Ideally, a virus receptor would fulfill three main characteristics: (1) a physical interaction between the virus and the receptor; (2) occupying the virus-binding site of the receptor (e.g. with an antibody directed against the receptor, should inhibit virus infection); and (3) the cellular sensitivity to virus infection should correlate with receptor expression. Therefore, cells lacking the receptor should not be infected, and transfection with the gene coding for the receptor would confer sensitivity to infection.

Keywords: Variola Virus; Rabies Virus; HIV-1; Hepatitis B Virus; Measles Virus; Japanese Encephalitis Virus; Hepatitis E Virus; Mumps Virus; Polio Virus; Rhino Virus

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Citation

Citation: Jai S Ghosh. “Host Cellular Receptors for Some Human Pathogenic Viruses- A Review". Acta Scientific Microbiology 3.6 (2020): 90-99.

Copyright

Copyright: © 2020 Jai S Ghosh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.